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Journal Articles

PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease

Devon Jeltema, Kennady Knox, Nicole Dobbs, Zhen Tang, Cong Xing, Antonina Araskiewicz, Kun Yang, Ivan Rodriguez Siordia, Jason Matthews, Michael Cohen, Nan Yan
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20241184.
https://doi.org/10.1084/jem.20241184
Published: 19 February 2025
View articletitled, PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease
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Includes: Supplementary data
Journal Articles

STING trafficking as a new dimension of immune signaling

In Special Collection:
Innate Immune Cells and Signaling 2023 , Innate Immune Signaling: From Host Defense to Disease Pathogenesis
Devon Jeltema, Kennady Abbott, Nan Yan
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (3): e20220990.
https://doi.org/10.1084/jem.20220990
Published: 27 January 2023
View articletitled, STING trafficking as a new dimension of immune signaling
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Journal Articles

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death

Jianjun Wu, Yu-Ju Chen, Nicole Dobbs, Tomomi Sakai, Jen Liou, Jonathan J. Miner, Nan Yan
Journal: Journal of Experimental Medicine
J Exp Med (2019) 216 (4): 867–883.
https://doi.org/10.1084/jem.20182192
Published: 18 March 2019
View articletitled, STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death
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Includes: Supplementary data
Journal Articles

N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1

Kun Yang, Ryan Huang, Haruhiko Fujihira, Tadashi Suzuki, Nan Yan
Journal: Journal of Experimental Medicine
J Exp Med (2018) 215 (10): 2600–2616.
https://doi.org/10.1084/jem.20180783
Published: 22 August 2018
View articletitled, N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1
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Includes: Supplementary data
Journal Articles

STING-associated vasculopathy develops independently of IRF3 in mice

In Special Collection:
Vascular Biology and Human Disease
James D. Warner, Ricardo A. Irizarry-Caro, Brock G. Bennion, Teresa L. Ai, Amber M. Smith, Cathrine A. Miner, Tomomi Sakai, Vijay K. Gonugunta, Jianjun Wu, Derek J. Platt, Nan Yan, Jonathan J. Miner
Journal: Journal of Experimental Medicine
J Exp Med (2017) 214 (11): 3279–3292.
https://doi.org/10.1084/jem.20171351
Published: 26 September 2017
View articletitled, STING-associated vasculopathy develops independently of IRF3 in mice
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Includes: Supplementary data
Journal Articles

RNase H2 catalytic core Aicardi-Goutières syndrome–related mutant invokes cGAS–STING innate immune-sensing pathway in mice

Vladislav Pokatayev, Naushaba Hasin, Hyongi Chon, Susana M. Cerritelli, Kiran Sakhuja, Jerrold M. Ward, H. Douglas Morris, Nan Yan, Robert J. Crouch
Journal: Journal of Experimental Medicine
J Exp Med (2016) 213 (3): 329–336.
https://doi.org/10.1084/jem.20151464
Published: 15 February 2016
View articletitled, RNase H2 catalytic core Aicardi-Goutières syndrome–related mutant invokes cGAS–STING innate immune-sensing pathway in mice
Open the PDF for RNase H2 catalytic core Aicardi-Goutières syndrome–related mutant invokes cGAS–STING innate immune-sensing pathway in mice in another window
Includes: Supplementary data