ON THE COVER
Wang et al. show that the transcription factor Batf is required for the induction of gut-homing receptors on T cells in response to retinoic acid. The image shows CD4+ (blue) and CD8+ (red) T cells in the small intestinal villi in wild-type mice.
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Brief Definitive Report
A primary immunodeficiency syndrome caused by loss-of-function mutations in the IL-21 receptor exhibits impaired B, T, and NK cell function.
Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition
Synovial IgG-expressing B cells from patients with rheumatoid arthritis show specificity for citrullinated autoantigens.
High-affinity antibodies reenter germinal centers (GCs) and limit antigen access, thus causing sustained directional evolution in GCs toward higher-affinity antibody production.
Endothelial cell–specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation
Endothelial cell ablation of the lymphotoxin-β receptor results in failure to develop peripheral lymph nodes and normal high endothelial venues, which impairs lymphocyte homing.
BATF is required for normal expression of gut-homing receptors by T helper cells in response to retinoic acid
Induction of gut-homing receptors in T cells in response to retinoic acid requires the transcription factor BATF.
IL-1R1 is required for dendritic cell–mediated T cell reactivation within the CNS during West Nile virus encephalitis
IL-1R1 signaling drives T cell activation in the CNS via effects on DC activation.
IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation
IL-27 promotes the differentiation of monocytes to HIV-resistant macrophages by down-regulating host factor SPTBN1.
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
Innate lymphoid type 2 cells maintain eosinophils and alternatively activated macrophages in visceral fat via the production of IL-5 and IL-13.
Innate Stat3-mediated induction of the antimicrobial protein Reg3γ is required for host defense against MRSA pneumonia
STAT3-mediated induction of Reg3γ enhances bacteriostatic and bactericidal activity to pulmonary Staphylococcus aureus.
Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination
Genetic deficiency for endoglin leads to increased metastatic capability by weakening the endothelial cell barrier.
p63 is up-regulated in melanoma and prevents nuclear accumulation of p53.
Cytotoxic T cells induce proliferation of chronic myeloid leukemia stem cells by secreting interferon-γ
Cytotoxic T cells increase leukemia stem cell numbers in a murine model of chronic myeloid leukemia.