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    Cover Image

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    Yang et al. show that immune tolerance to self-antigens impedes the generation of some broadly protective antibodies that bind to HIV gp41. One self-antigen, kynureninase, is mutated in opossums, allowing these marsupials to generate high serum antibody titers to the corresponding HIV epitope. The cover image depicts a HIV virus (orange) with viral spikes containing gp41 subunits (blue) and Y-shaped antibodies (green). Artwork by Rachel Urkowitz (
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ISSN 0022-1007
EISSN 1540-9538
In this Issue


Hal Broxmeyer highlights the multitude of erythropoietin’s biological functions, including a novel EPO–EPOR signaling cascade involving a serpin–lysosome–cathepsin axis.


McCoy and Weiss discuss the generation of neutralizing antibodies to HIV induced by immunization.

Brief Definitive Report

Serpina3g/Spi2A inhibits cathepsins B/L to enhance erythropoietin induced red blood cell formation.

DNA double-strand breaks induced during Igκ recombination signal through ATM to suppress the initiation of additional Vκ-to-Jκ rearrangements.


Immunological tolerance to self-antigen impairs humoral responses to HIV-1.

Blockade of C3aR/C5aR signaling in nT reg cells augments in vitro and in vivo suppression, abrogates autoimmune colitis, and prolongs allogeneic skin graft survival.

Expression of the transcription factor Helios identifies thymocyte divergence during positive and negative selection.

Macroautophagy supports central CD4+ T cell tolerance by facilitating the direct presentation of endogenous self-antigens by medullary thymic epithelial cells.

Notch behaves as a tumor suppressor in AML, and Notch activation induces cell cycle arrest, differentiation, and apoptosis of AML-initiating cells.

Activating Notch with a Notch agonist peptide induces apoptosis in AML patient samples.

Elevating HDL levels reduces Glut1 expression, dampens myeloproliferation, and prevents fat loss in multiple mouse models.

Wiskott-Aldrich Syndrome protein (WASp)–mediated actin polymerization controls intracellular trafficking and compartmentalization of TLR9 ligands in plasmacytoid dendritic cells.

Neutrophil-produced thromboxane A2 controls the magnitude and spread of T cell responses to distal lymph nodes.

Plasmodium falciparum infection leads to the development of protective classical and atypical memory B cell antibody responses.

Iron uptake promotes hydrogen peroxide–dependent differentiation of Leishmania promastigotes into infective amastigotes.

CD4+ T cell activation–induced Argonaute degradation and global miRNA downregulation promotes acquisition of helper T cell effector functions.

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