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Cover Image
Cover Image
ON THE COVER
Yang et al. show that immune tolerance to self-antigens impedes the generation of some broadly protective antibodies that bind to HIV gp41. One self-antigen, kynureninase, is mutated in opossums, allowing these marsupials to generate high serum antibody titers to the corresponding HIV epitope. The cover image depicts a HIV virus (orange) with viral spikes containing gp41 subunits (blue) and Y-shaped antibodies (green). Artwork by Rachel Urkowitz ([email protected]).
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Review
Erythropoietin: multiple targets, actions, and modifying influences for biological and clinical consideration
Hal Broxmeyer highlights the multitude of erythropoietin’s biological functions, including a novel EPO–EPOR signaling cascade involving a serpin–lysosome–cathepsin axis.
Neutralizing antibodies to HIV-1 induced by immunization
McCoy and Weiss discuss the generation of neutralizing antibodies to HIV induced by immunization.
Brief Definitive Report
Erythropoietin-directed erythropoiesis depends on serpin inhibition of erythroblast lysosomal cathepsins
Serpina3g/Spi2A inhibits cathepsins B/L to enhance erythropoietin induced red blood cell formation.
The Ataxia Telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements
DNA double-strand breaks induced during Igκ recombination signal through ATM to suppress the initiation of additional Vκ-to-Jκ rearrangements.
Article
Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies
Immunological tolerance to self-antigen impairs humoral responses to HIV-1.
Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells
Blockade of C3aR/C5aR signaling in nT reg cells augments in vitro and in vivo suppression, abrogates autoimmune colitis, and prolongs allogeneic skin graft survival.
Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB
Expression of the transcription factor Helios identifies thymocyte divergence during positive and negative selection.
Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance
Macroautophagy supports central CD4+ T cell tolerance by facilitating the direct presentation of endogenous self-antigens by medullary thymic epithelial cells.
Notch pathway activation targets AML-initiating cell homeostasis and differentiation
Notch behaves as a tumor suppressor in AML, and Notch activation induces cell cycle arrest, differentiation, and apoptosis of AML-initiating cells.
Notch activation inhibits AML growth and survival: a potential therapeutic approach
Activating Notch with a Notch agonist peptide induces apoptosis in AML patient samples.
HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders
Elevating HDL levels reduces Glut1 expression, dampens myeloproliferation, and prevents fat loss in multiple mouse models.
Wiskott-Aldrich syndrome protein–mediated actin dynamics control type-I interferon production in plasmacytoid dendritic cells
Wiskott-Aldrich Syndrome protein (WASp)–mediated actin polymerization controls intracellular trafficking and compartmentalization of TLR9 ligands in plasmacytoid dendritic cells.
Neutrophils control the magnitude and spread of the immune response in a thromboxane A2-mediated process
Neutrophil-produced thromboxane A2 controls the magnitude and spread of T cell responses to distal lymph nodes.
Atypical and classical memory B cells produce Plasmodium falciparum neutralizing antibodies
Plasmodium falciparum infection leads to the development of protective classical and atypical memory B cell antibody responses.
Iron uptake controls the generation of Leishmania infective forms through regulation of ROS levels
Iron uptake promotes hydrogen peroxide–dependent differentiation of Leishmania promastigotes into infective amastigotes.
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire
CD4+ T cell activation–induced Argonaute degradation and global miRNA downregulation promotes acquisition of helper T cell effector functions.
