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Cover Image
Cover Image
ON THE COVER
Hoogeboom et al. describe a new subset of mutated B cell chronic lymphocytic leukemia that expresses stereotypic B cell receptors specific for β-(1,6)-glucan, a cell wall antigen of yeast and filamentous fungi. The cover depicts B cells (blue and green circles with Y-shaped projections) proliferating in response to fungi (pink). Artwork by Emilie Clark ([email protected]).
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Review
Clonal expansion in B-CLL: Fungal drivers or self-service?
Mel Greaves discusses the mechanisms underlying transformation in B cell chronic lymphocytic leukemia, including a new study suggesting a role for BCR ligation driven by recognition of an antigenic component of common yeast and fungi.
Brief Definitive Report
LECT2 protects mice against bacterial sepsis by activating macrophages via the CD209a receptor
Leukocyte cell–derived chemotaxin 2 enhances phagocytosis and bacterial killing of macrophages to improve the outcome of bacterial-induced sepsis.
The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML
Inactivation of Llgl1 enhances HSC self-renewal and fitness and is associated with unfavorable outcome in human AML.
The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain
The protease Sppl2a cleaves the N-terminal fragment of invariant chain (CD74) and is required for efficient B cell development and function.
B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8− dendritic cells require the intramembrane endopeptidase SPPL2A
Mice lacking activity of the intramembrane protease SPPL2A exhibit humoral immunodeficiency and lack mature B cell subsets.
Article
The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain
The intramembrane protease SPPL2a cleaves the NTF of invariant chain (CD74), which is essential for normal trafficking of MHC class II–containing endosomes and thus for B cell development and function.
A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi
A subset of chronic lymphocytic leukemia with mutated IGHV-genes express BCRs specific for an antigenic determinant of yeast and filamentous fungi, β-(1,6)-glucan.
Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling
Hes1 is required for the development of hematopoietic stem cells in the mouse embryo through repression of Gata2.
Poly(ADP-ribose) polymerase 1 regulates nuclear reprogramming and promotes iPSC generation without c-Myc
Parp1 can replace c-Myc to promote induced pluripotent stem cell (iPSC) generation.
Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell–mediated deletion
Hepatic NK cells eliminate HBV-specific T cells dependent on TRAIL and TRAIL-R2 interactions to limit antiviral immunity in chronic infection.
Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching
CtBP-interacting protein, exonuclease 1, and RecQ helicases contribute to the processing of DNA ends during double-strand break repairs in primary lymphocytes.
Global analysis of B cell selection using an immunoglobulin light chain–mediated model of autoreactivity
The nature of the immunoglobulin light chain affects peripheral B cell tolerance and autoreactivity.
Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production
Follicular T helper cells are the major reservoir for HIV infection and accumulate during chronic HIV infection.
Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival
Colony-stimulating factor 1 and IL-34 protect against and partially reverse neurodegeneration in mice in part via promoting CREB signaling.
CD98hc (SLC3A2) regulation of skin homeostasis wanes with age
Loss of CD98hc expression in young adult skin induces changes similar to those associated with aging, including improper skin homeostasis and epidermal wound healing.
Serum proteomics reveals systemic dysregulation of innate immunity in type 1 diabetes
Proteomics analysis identifies human serum proteins involved with innate immune responses, complement activation, and blood coagulation that are diagnostic for type 1 diabetes.
