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    Cover Image

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    ON THE COVER
    Croci et al. find that hypoxia drives expression of the regulatory lectin galectin-1 in Kaposi's sarcoma lesions and that blocking galectin-1 inhibits hypoxia-driven angiogenesis and tumor growth. Image shows galectin-1 (red) expression in low-oxygen (green) regions of a Kaposi's sarcoma lesion. Artwork by New York-based artist Emilie Clark (emilie@emileclark.com).
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ISSN 0022-1007
EISSN 1540-9538
In this Issue

Minireview

Ware and Benedict discuss the pros and cons of TRAIL signaling in the context of bacterial infection and vascular disease.

Brief Definitive Report

CARD11 signaling determines whether antigen stimulation induces B cells to proliferate or die.

Article

Genetic deletion of TRAIL or antibody blockade prevents the development of pulmonary arterial hypertension and can reverse vascular remodeling in established disease.

Neutrophil-derived TRAIL induces apoptosis of alveolar macrophages, limiting the spread of S. pneumoniae infection.

TRPC6-dependent Ca2+ flux in endothelial cells after TLR4-induced diacylglycerol production mediates lung endothelial barrier disruption and inflammation induced by LPS.

An evolutionary and functional analysis of mammalian AIM2-like receptors reveals remarkable diversity and redundancy.

Disrupting Gal-1 interactions with N-glycans prevents hypoxia-driven angiogenesis to suppress tumorigenesis of Kaposi’s sarcoma

Neuropilin 1 mediates anti-tumor control by promoting regulatory T cell infiltration.

A CBFA2T3-GLIS2 fusion gene was identified in 31% of non–Down syndrome AMKL.

Axl expression is induced by TGF-β1 during Langerhans cell differentiation and enhances apoptotic cell uptake and blocks proinflammatory cytokine production.

Transcriptional activator Oct2 and cofactor OBF-1 regulate B cell IL-6 to induce T cell production of IL-21, to support Tfh cell development in antiviral immunity.

Both deletion and anergy shape B cell tolerance to membrane-bound antigens.

B cell memory is generated along two fundamentally distinct cellular differentiation pathways.

OX40 engagement induces a cytotoxic CD4+ T cell subpopulation to eradicate advance melanomas

Tryptophan hydroxylase deficiency in mast cells breaks allograft tolerance, induces tumor remission, and intensifies neuroinflammation.

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