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    Cover Image

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    Long-term nicotine exposure causes two neurotransmitter receptors to interact in the brain. Fang Li et al. generated a peptide inhibitor to prevent this receptor complex, allowing rats weaned off nicotine to reduce addiction relapse. Image shows a neuronal synapse with the peptide inhibitor (green) preventing the two neurotransmitter receptors (blue and red) from forming a complex. Artwork by New York-based artist Emilie Clark (
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ISSN 0022-1007
EISSN 1540-9538
In this Issue


Hla et al. highlight the multitude of biological functions of S1P with a focus on its recently identified role in thrombopoiesis.

Brief Definitive Report

Disrupting the α7nAChR–NMDAR complex blocks cue-induced nicotine seeking.

Anti-ApoE antibody reduces amyloid deposition and enhances the microglial response to Aβ plaques in an Alzheimer’s disease mouse model.

Deletion of early growth response gene Egr2 prevents anergy induction through diacylglycerol kinase α and restores Ras/MAPK signaling in T cells.


Sphingosine 1-phosphate guides the elongation of megakaryocytic proplatelet extensions and triggers their shedding.

Unmutated CLL derives from unmutated mature CD5+ B cells and mutated CLL derives from CD5+CD27+ post–germinal center B cells.

Distinct nuclear subsets of cyclin D3 differ in their subcompartmentalization, function, and regulation.

Endogenous thymidine plays a critical role in the induction of replication stress in thymocytes.

Deletion of p38 MAP kinase p38 d results in decreased alveolar neutrophil accumulation and attenuation of acute lung injury through activation of protein kinase D1 and PTEN.

Germline mutations in CARD11 that result in constitutive NF-κB activation and selective B cell expansion underlie congenital B cell lymphocytosis.

Two cytokines that signal through the common gamma chain receptor, IL-7 and IL-15, are responsible for the differentiation of developing thymocytes into CD8+ cytotoxic lineage T cells in mice.

The G proteins Gα12/Gα13 and Gαq/Gα11 have opposing effects on vascular remodeling by differentially regulating vascular smooth muscle cell differentiation.

proNGF and p75NTR are induced following fatal myocardial infraction and are required for the development of microvascular injury.

Expressing a wild mouse Fcgr2b promoter variant in C57BL/6 mice enhances germinal center responses and increases affinity maturation and autoantibody production.


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