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    Cover Image

    issue cover

    Nordenfelt et al. show that the orientation of IgG binding to proteins on the surface of Streptococcal bacteria depends on the antibody concentration of the environment. In saliva, where concentrations are low, binding is mediated by the Fc portion of the antibody, affording the bug protection against phagocytic killing. In contrast, antibody binding occurs via the Fab region in the high-concentration environment of the plasma. The cover image shows Fab-mediated binding of antibodies (red) to the bacteria (green), which confers susceptibility to phagocytic killing. Artwork by Rachel Urkowitz (
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ISSN 0022-1007
EISSN 1540-9538
In this Issue

Brief Definitive Report

Homozygous missense mutations in POLE1 caused an inherited disorder characterized by facial dysmorphism, immunodeficiency, livedo, and short stature.

The transcription factor T-bet drives the differentiation of NKp46-expressing IL-22–producing innate lymphoid cells

RAGE is required for LPA-mediated vascular signaling and tumorigenesis


NK cells treated with a cocktail of IL-12, IL-15, and IL-18 persist with sustained effector function in vivo and enhance tumor immunotherapy.

Bacterial surface proteins switch the orientation of IgG binding depending on the antibody concentration of their environment.

The colitis-associated glycome mediates CD4+ T cell expansion and contributes to the exacerbation of T cell–mediated intestinal inflammation.

Pest resistance molecules, α-amylase/trypsin inhibitors from wheat, activate innate immune cells through engagement of TLR4 to elicit inflammatory responses in the intestine.

E2F transcription factors regulate expression of RAE-1 family NKG2D ligands in cancer cells and normal proliferating cells to promote wound healing and immune recognition.

A PI3K- and Akt-independent pathway mediated by mTORC1 regulates expression of HIF1 in CD8+ T cells and is required to sustain glucose metabolism and regulate cell trafficking.

The transcriptional repressor BCL6 reduces miRNA levels in germinal center B cells to increase AID expression.

Bcl11a regulates development of lymphoid cells in adult mice in part by inhibiting expression of p53.

The PD-1–PD-L1 pathway inhibits perforin-mediated killing of PD-L1+ vascular endothelial cells by CD8+ T cells, thereby limiting vascular damage during systemic LCMV infection.

To be added


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