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Journal Articles

Csk restrains BCR-mediated ROS production and contributes to germinal center selection and affinity maturation

Takeshi Inoue, Yuma Matsumoto, Chie Kawai, Mao Ito, Shigeyuki Nada, Masato Okada, Tomohiro Kurosaki

J Exp Med (2024) 221 (7): e20231996.

https://doi.org/10.1084/jem.20231996

Published: 16 May 2024

View article titled, Csk restrains BCR-mediated ROS production and contributes to germinal center selection and affinity maturation

Includes: Supplementary data

Journal Articles

STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells

Yutaro Yada, Masanori Matsumoto, Takeshi Inoue, Akemi Baba, Ryota Higuchi, Chie Kawai, Masashi Yanagisawa, Daisuke Kitamura, Shouichi Ohga, Tomohiro Kurosaki, Yoshihiro Baba

J Exp Med (2023) 221 (1): e20222178.

https://doi.org/10.1084/jem.20222178

Published: 30 October 2023

View article titled, STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells

Includes: Supplementary data

Journal Articles

Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow

In Special Collection:

Immunology Update Winter 2023 , B Cell Biology in Health and Diseases

Takuya Koike, Kentaro Fujii, Kohei Kometani, Noah S. Butler, Kenji Funakoshi, Shinya Yari, Junichi Kikuta, Masaru Ishii, Tomohiro Kurosaki, Wataru Ise

J Exp Med (2022) 220 (2): e20221717.

https://doi.org/10.1084/jem.20221717

Published: 14 December 2022

View article titled, Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow

Journal Articles

Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees

In Special Collection:

B cells, Infectious Diseases, and Autoimmunity

J Exp Med (2022) 220 (2): e20221786.

https://doi.org/10.1084/jem.20221786

Published: 13 December 2022

View article titled, Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees

Includes: Supplementary data

Journal Articles

BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis

In Special Collection:

Innate Immune Cells and Signaling 2023

J Exp Med (2022) 219 (12): e20211476.

https://doi.org/10.1084/jem.20211476

Published: 30 September 2022

View article titled, BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis

Includes: Supplementary data

Journal Articles

B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice

Michelle S.J. Lee, Takeshi Inoue, Wataru Ise, Julia Matsuo-Dapaah, James B. Wing, Burcu Temizoz, Kouji Kobiyama, Tomoya Hayashi, Ashwini Patil, Shimon Sakaguchi, A. Katharina Simon, Jelena S. Bezbradica, Satoru Nagatoishi, Kouhei Tsumoto, Jun-Ichiro Inoue, Shizuo Akira, Tomohiro Kurosaki, Ken J. Ishii, Cevayir Coban

J Exp Med (2021) 219 (2): e20211336.

https://doi.org/10.1084/jem.20211336

Published: 15 December 2021

View article titled, B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice

Includes: Supplementary data

Journal Articles

Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients

J Exp Med (2021) 218 (12): e20211327.

https://doi.org/10.1084/jem.20211327

Published: 14 October 2021

View article titled, Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients

Includes: Supplementary data

Journal Articles

Glycan engineering of the SARS-CoV-2 receptor-binding domain elicits cross-neutralizing antibodies for SARS-related viruses

In Special Collection:

Immunology Update Winter 2022

Ryo Shinnakasu, Shuhei Sakakibara, Hiromi Yamamoto, Po-hung Wang, Saya Moriyama, Nicolas Sax, Chikako Ono, Atsushi Yamanaka, Yu Adachi, Taishi Onodera, Takashi Sato, Masaharu Shinkai, Ryosuke Suzuki, Yoshiharu Matsuura, Noritaka Hashii, Yoshimasa Takahashi, Takeshi Inoue, Kazuo Yamashita, Tomohiro Kurosaki

J Exp Med (2021) 218 (12): e20211003.

https://doi.org/10.1084/jem.20211003

Published: 08 October 2021

View article titled, Glycan engineering of the SARS-CoV-2 receptor-binding domain elicits cross-neutralizing antibodies for SARS-related viruses

Includes: Supplementary data

Journal Articles

Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal

In Special Collection:

JEM Immunology Collection 2021 , Metabolism in Homeostasis and Disease

Takeshi Inoue, Ryo Shinnakasu, Chie Kawai, Wataru Ise, Eiryo Kawakami, Nicolas Sax, Toshihiko Oki, Toshio Kitamura, Kazuo Yamashita, Hidehiro Fukuyama, Tomohiro Kurosaki

J Exp Med (2020) 218 (1): e20200866.

https://doi.org/10.1084/jem.20200866

Published: 12 October 2020

View article titled, Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal

Journal Articles

BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression

In Special Collection:

JEM 2020 Update on Cancer Immunology and Immunotherapy

Francis M. Grant, Jie Yang, Rabab Nasrallah, James Clarke, Firas Sadiyah, Sarah K. Whiteside, Charlotte J. Imianowski, Paula Kuo, Panagiota Vardaka, Tihomir Todorov, Nordin Zandhuis, Ilinca Patrascan, David F. Tough, Kohei Kometani, Robert Eil, Tomohiro Kurosaki, Klaus Okkenhaug, Rahul Roychoudhuri

J Exp Med (2020) 217 (9): e20190711.

https://doi.org/10.1084/jem.20190711

Published: 09 June 2020

View article titled, BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression

Includes: Supplementary data

Journal Articles

Trim33 mediates the proinflammatory function of Th17 cells

In Special Collection:

Cytokines 2018

Shinya Tanaka, Yu Jiang, Gustavo J. Martinez, Kentaro Tanaka, Xiaowei Yan, Tomohiro Kurosaki, Vesa Kaartinen, Xin-Hua Feng, Qiang Tian, Xiaohu Wang, Chen Dong

J Exp Med (2018) 215 (7): 1853–1868.

https://doi.org/10.1084/jem.20170779

Published: 21 June 2018

View article titled, Trim33 mediates the proinflammatory function of Th17 cells

Includes: Supplementary data

Journal Articles

The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help

Takeshi Inoue, Ryo Shinnakasu, Wataru Ise, Chie Kawai, Takeshi Egawa, Tomohiro Kurosaki

J Exp Med (2017) 214 (4): 1181–1198.

https://doi.org/10.1084/jem.20161263

Published: 28 March 2017

View article titled, The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help

Journal Articles

Distinct germinal center selection at local sites shapes memory B cell response to viral escape

Yu Adachi, Taishi Onodera, Yuki Yamada, Rina Daio, Makoto Tsuiji, Takeshi Inoue, Kazuo Kobayashi, Tomohiro Kurosaki, Manabu Ato, Yoshimasa Takahashi

J Exp Med (2015) 212 (10): 1709–1723.

https://doi.org/10.1084/jem.20142284

Published: 31 August 2015

View article titled, Distinct germinal center selection at local sites shapes memory B cell response to viral escape

Includes: Supplementary data

Journal Articles

CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability

Takeshi Inoue, Masahiro Morita, Atsushi Hijikata, Yoko Fukuda-Yuzawa, Shungo Adachi, Kyoichi Isono, Tomokatsu Ikawa, Hiroshi Kawamoto, Haruhiko Koseki, Tohru Natsume, Taro Fukao, Osamu Ohara, Tadashi Yamamoto, Tomohiro Kurosaki

J Exp Med (2015) 212 (9): 1465–1479.

https://doi.org/10.1084/jem.20150384

Published: 03 August 2015

View article titled, CNOT3 contributes to early B cell development by controlling <em>Igh</em> rearrangement and <em>p53</em> mRNA stability

Includes: Supplementary data

Journal Articles

Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory

Tomohiro Kaji, Akiko Ishige, Masaki Hikida, Junko Taka, Atsushi Hijikata, Masato Kubo, Takeshi Nagashima, Yoshimasa Takahashi, Tomohiro Kurosaki, Mariko Okada, Osamu Ohara, Klaus Rajewsky, Toshitada Takemori

J Exp Med (2012) 209 (11): 2079–2097.

https://doi.org/10.1084/jem.20120127

Published: 01 October 2012

View article titled, Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory

Includes: Supplementary data

Journal Articles

CIN85 drives B cell responses by linking BCR signals to the canonical NF-κB pathway

Kohei Kometani, Takayuki Yamada, Yoshiteru Sasaki, Tadashi Yokosuka, Takashi Saito, Klaus Rajewsky, Masamichi Ishiai, Masaki Hikida, Tomohiro Kurosaki

J Exp Med (2011) 208 (7): 1447–1457.

https://doi.org/10.1084/jem.20102665

Published: 27 June 2011

View article titled, CIN85 drives B cell responses by linking BCR signals to the canonical NF-κB pathway

Includes: Supplementary data

Journal Articles

PLC-γ2 is essential for formation and maintenance of memory B cells

Masaki Hikida, Stefano Casola, Noriko Takahashi, Tomohiro Kaji, Toshitada Takemori, Klaus Rajewsky, Tomohiro Kurosaki

J Exp Med (2009) 206 (3): 681–689.

https://doi.org/10.1084/jem.20082100

Published: 09 March 2009

View article titled, PLC-γ2 is essential for formation and maintenance of memory B cells

Includes: Supplementary data

Journal Articles

Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen

Michele Weber, Bebhinn Treanor, David Depoil, Hisaaki Shinohara, Naomi E. Harwood, Masaki Hikida, Tomohiro Kurosaki, Facundo D. Batista

J Exp Med (2008) 205 (5): 1243.

https://doi.org/10.1084/jem.20072619040408c

Published: 14 April 2008

View article titled, Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen

Journal Articles

Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen

Michele Weber, Bebhinn Treanor, David Depoil, Hisaaki Shinohara, Naomi E. Harwood, Masaki Hikida, Tomohiro Kurosaki, Facundo D. Batista

J Exp Med (2008) 205 (4): 853–868.

https://doi.org/10.1084/jem.20072619

Published: 24 March 2008

View article titled, Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen

Includes: Supplementary data

Journal Articles

IκB kinase β–induced phosphorylation of CARMA1 contributes to CARMA1–Bcl10–MALT1 complex formation in B cells

Hisaaki Shinohara, Shiori Maeda, Hiroshi Watarai, Tomohiro Kurosaki

J Exp Med (2007) 204 (13): 3285–3293.

https://doi.org/10.1084/jem.20070379

Published: 17 December 2007

View article titled, IκB kinase β–induced phosphorylation of CARMA1 contributes to CARMA1–Bcl10–MALT1 complex formation in B cells

NARROW

Csk restrains BCR-mediated ROS production and contributes to germinal center selection and affinity maturation

STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells

Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow

Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees

BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis

B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice

Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients

Glycan engineering of the SARS-CoV-2 receptor-binding domain elicits cross-neutralizing antibodies for SARS-related viruses

Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal

BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression

Trim33 mediates the proinflammatory function of Th17 cells

The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help

Distinct germinal center selection at local sites shapes memory B cell response to viral escape

CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability

Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory

CIN85 drives B cell responses by linking BCR signals to the canonical NF-κB pathway

PLC-γ2 is essential for formation and maintenance of memory B cells

Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen

Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen

IκB kinase β–induced phosphorylation of CARMA1 contributes to CARMA1–Bcl10–MALT1 complex formation in B cells

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