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Cover Image
Cover Image
ON THE COVER
Hara-Chikuma et al. demonstrate that the water/glycerol channel aquaporin-3 (AQP3) regulates chemokine-dependent trafficking of T cells to inflamed skin via uptake of hydrogen peroxide (H2O2). Image shows an abstraction of T cells (green) expressing AQP3 receptors (blue) with H2O2 uptake (yellow) migrating to the skin (red). Artwork by Rachel Urkowitz ([email protected]).
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Brief Definitive Report
TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1
TRAF-interacting protein (TRIP) negatively regulates TLR3/4- and RIG-I–induced IFN-β signaling by promoting K48-linked ubiquitination and proteasomal degradation of TBK1.
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
Neuropilin-1 is identified as a surface marker to distinguish different Foxp3+ T reg cell subsets under homeostatic conditions.
Article
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
Neuropilin-1 surface expression discriminates between nT reg cells with stable expression and Nrp1 low iT reg cells showing inducible expression under inflammatory conditions.
Chemokine-dependent T cell migration requires aquaporin-3–mediated hydrogen peroxide uptake
The water/glycerol channel aquaporin-3 is required for chemokine-dependent T cell migration during immune responses.
Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor
Schistosome ribonuclease Omega-1 primes DCs to generate Th2 responses by binding and internalization by the mannose receptor and by subsequently impairing protein synthesis.
Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection
Autoimmunity occurs because central and peripheral tolerance mechanisms fail to tolerize T cells with weak self-reactivity to tissue-restricted antigen.
Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease
TCR signal attenuation selectively favors Foxp3 expression and T reg cell lineage commitment.
Dual-reactive B cells are autoreactive and highly enriched in the plasmablast and memory B cell subsets of autoimmune mice
Dual–light chain–expressing B cells in autoimmune prone mice increase with age, contribute to the memory and plasma cell compartments, and are autoreactive.
Macrophages induce differentiation of plasma cells through CXCL10/IP-10
Macrophage production of CXCL10 amplifies the production of IL-6 by B cells, leading to plasma cell differentiation.
Extrafollicular B cell activation by marginal zone dendritic cells drives T cell–dependent antibody responses
DCIR2+ DCs can initiate extrafollicular B cell responses to T cell–dependent antigen.
Bcl6 expression specifies the T follicular helper cell program in vivo
A novel Bcl6 reporter mouse is used to dissect the developmental requirements, plasticity, and genetic profile of Tfh cells.
LAPCs promote follicular helper T cell differentiation of Ag-primed CD4+ T cells during respiratory virus infection
Late activator antigen-presenting cells promote Tfh differentiation of antigen-primed CD4+ T cells and antibody responses in influenza A virus infection.
Cancer immunoediting by the innate immune system in the absence of adaptive immunity
In the absence of adaptive immunity, NK cells polarize M1 macrophages to facilitate cancer immunoediting.
Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts
Inhibition of macrophage SIRPα–CD47 interactions mediates phagocytosis and clearance of acute myeloid leukemia stem cells.
