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Brief Definitive Report

HMGB1 orchestrates leukocyte recruitment and their induction to secrete inflammatory cytokines by switching between mutually exclusive redox states.

Binding of Smad3 to the foxp3 enhancer is not required for thymic T reg cell development, but thymic involution with aging reveals the contribution of TGF-β–Smad2 signaling in gut T reg cell development.


Notch2 mutations represent the most frequent lesion in splenic marginal zone lymphoma.

NOTCH2 mutations in splenic marginal zone lymphoma are associated with poor prognosis.

Two unrelated children with HSE carry distinct heterozygous mutations in the gene encoding TANK-binding kinase 1.

Conventional DCs from mice lacking zDC (also known as Zbtb46) express more MHCII and produce more VEGF in the steady state.

IL-1β promotes chronic intestinal inflammation through recruitment of granulocytes, activation of ILCs, accumulation of pathogenic T cells, and promotion of Th17 responses.

Wnt modulates glioma vascularization by regulating PDGF-B expression.

B cell development requires the Zinc-finger protein and ATM substrate ASCIZ to signal through DYNLL1 and Bim.

The mitochondrial flavoprotein Aif facilitates murine thymocyte development by reducing oxidative stress.

By suppressing expression of TRAF6 and IRAK1, miR-146a regulates NF-κB activation in T cells through a negative feedback loop and controls the resolution of T cell responses in mice.

MyD88 blockade exaggerates the ability of dendritic cells to promote the transition from chronic pancreatitis to pancreatic cancer.

Keratinocyte MyD88 is a component of an IL-1α–IL-1R autocrine loop that drives Ras-mediated transformation in vitro and contributes to skin tumor formation in vivo.

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