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    Surface rendering of an electron tomogram shows the large membrane cisternae that accumulate in the synaptic boutons of shits1; shi-4C flies after photoinactivation of the GTPase shibire/dynamin. Kasprowicz et al. reveal that, in addition to its well-known role in vesicle scission, dynamin helps recruit clathrin to the presynaptic membrane at the initial stages of endocytosis, a step that inhibits bulk membrane retrieval. Separate cisternae are labeled with different colors. Image prepared by Katarzyna Miskiewicz.
    © 2014 Kasprowicz et al.
    See page 1141.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

The tumor suppressor limits cell invasion by inducing a mitochondrial protease to cleave the actin cytoskeleton.

People & Ideas

Schuh studies the assembly and positioning of the oocyte meiotic spindle.



SUN proteins in the inner nuclear membrane function in mitotic membrane remodeling during nuclear envelope breakdown.

Ensconsin cooperates with its binding partner, Kinesin-1, during interphase to trigger centrosome separation, but it promotes microtubule polymerization independently of Kinesin-1 to control spindle length during mitosis.


ComplexinII and SynaptotagminI coordinately transform the constitutively active SNARE-mediated fusion mechanism into a highly synchronized, Ca2+-triggered release apparatus.

Drosophila Dynamin prevents bulk membrane endocytosis through effects on AP2- and Clathrin-mediated stabilization of endocytic pits.

The Toll-like receptor Tollo positively regulates growth of the Drosophila larval neuromuscular junction through the JNK pathway after activation by the neurotrophin Spätzle3.

The p53 family member TAp73 is required for sperm maturation through promotion of adhesion between developing germ cells and Sertoli nurse cells.

The tumor suppressor p53 induces activation of the mitochondrial protease HtrA2/Omi and prevents Ras-driven invasion by modulating the actin cytoskeleton.

Localized F-actin disassembly by ADF/cofilin drives invadopodial membrane recycling through endolysosomes, which promotes efficient cell transmigration through the basement membrane.

Functionally and spatially distinct PI 3-K pathways act either early to promote myelination downstream of axonal Neuregulin1 or late to inhibit myelination downstream of α6β4 integrin and Sgk1.

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