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The tumor suppressor limits cell invasion by inducing a mitochondrial protease to cleave the actin cytoskeleton.

People & Ideas

Schuh studies the assembly and positioning of the oocyte meiotic spindle.

Review

In Special Collection:
Mitochondrial biology reviews

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SUN proteins in the inner nuclear membrane function in mitotic membrane remodeling during nuclear envelope breakdown.

Ensconsin cooperates with its binding partner, Kinesin-1, during interphase to trigger centrosome separation, but it promotes microtubule polymerization independently of Kinesin-1 to control spindle length during mitosis.

Article

ComplexinII and SynaptotagminI coordinately transform the constitutively active SNARE-mediated fusion mechanism into a highly synchronized, Ca2+-triggered release apparatus.

Drosophila Dynamin prevents bulk membrane endocytosis through effects on AP2- and Clathrin-mediated stabilization of endocytic pits.

The Toll-like receptor Tollo positively regulates growth of the Drosophila larval neuromuscular junction through the JNK pathway after activation by the neurotrophin Spätzle3.

The p53 family member TAp73 is required for sperm maturation through promotion of adhesion between developing germ cells and Sertoli nurse cells.

The tumor suppressor p53 induces activation of the mitochondrial protease HtrA2/Omi and prevents Ras-driven invasion by modulating the actin cytoskeleton.

Localized F-actin disassembly by ADF/cofilin drives invadopodial membrane recycling through endolysosomes, which promotes efficient cell transmigration through the basement membrane.

Functionally and spatially distinct PI 3-K pathways act either early to promote myelination downstream of axonal Neuregulin1 or late to inhibit myelination downstream of α6β4 integrin and Sgk1.

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