In This Issue
People & Ideas
Ca2+–Calmodulin regulates SNARE assembly and spontaneous neurotransmitter release via v-ATPase subunit V0a1
Ca2+–Calmodulin binding to neuronal v-ATPase V0 subunit a1 (V100) regulates SNARE complex assembly for a putative subset of synaptic vesicles that sustain spontaneous release in Drosophila.
Coordinated binding of Vps4 to ESCRT-III drives membrane neck constriction during MVB vesicle formation
Vps4 both recycles ESCRT-III subunits and cooperates with ESCRT-III to drive distinct membrane remodeling steps that lead to efficient membrane scission during the biogenesis of multivesicular bodies.
Signal peptide binding modulates assembly of chloroplast Tha4 onto the twin-arginine translocase cpTatC subunit to assemble a functional protein-conducting pore.
Axon initial segment cytoskeleton comprises a multiprotein submembranous coat containing sparse actin filaments
The axon initial segment of differentiated neurons contains a dense submembranous cytoskeleton that overlays microtubule bundles and includes two sparse actin populations: short, stable actin filaments and longer, dynamic non-oriented filaments.
A contractile actomyosin meshwork at the top of a cell is mechanically coupled to dorsal actin fibers that are anchored via focal adhesions to the cell surface, generating a counterbalanced adhesion/contraction system that drives cell shape changes.
In addition to stimulating skeletal muscle growth and repair, Wnt7a/Fzd7 signaling increases the polarity and directional migration of myogenic progenitors and improves the efficacy of muscle stem cell therapy.
Characterization of a new biosensor for PtdIns4P reveals a wider cellular distribution for the polyphosphoinositide than the Golgi localization reported previously, including pools in both the plasma membrane and late endosomes/lysosomes.