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People & Ideas
The role of Greatwall kinase in autoregulatory activation of cyclin B–Cdk1 at M phase onset can be bypassed by cyclin B–Cdk1–mediated direct phosphorylation of Arpp19, leading to PP2A-B55 inhibition.
MAPK and Cdk1 play compensatory roles in suppressing APC/C activity early in prometaphase, thereby allowing accumulation of APC/C substrates essential for meiosis I.
Mad1 recruitment to metaphase kinetochores reactivates the mitotic checkpoint, which requires the C terminus of Mad1 in addition to its Mad2-binding domain.
Ubiquitylation by the Ltn1 E3 ligase protects 60S ribosomes from starvation-induced selective autophagy
The E3 ligase Ltn1 and the deubiquitylase Ubp3-Bre5 titrate the level of ribosomal subunit ubiquitylation and thereby set the rate of ribosomal protein degradation by ribophagy in response to nutrient supply and the level of protein translation.
OPA1 processing by YEM1L and OMA1 is dispensable for mitochondrial fusion and instead drives mitochondrial fragmentation, which is crucial for mitochondrial integrity and quality control.
PML multimerization into nuclear bodies following its oxidation promotes sumoylation and sequestration of partner proteins in these structures.
EB1 enables spindle microtubules to regulate the phosphorylation of kinetochores through recruitment of Aurora B kinase.
The kinesin-8 Kip3 scales anaphase spindle length by suppression of midzone microtubule polymerization
The depolymerase activity of Kip3 suppresses spindle microtubule polymerization to limit spindle midzone length and prevent microtubule buckling in response to sliding forces.
Cytokinetic nodes in fission yeast arise from two distinct types of nodes that merge during interphase
Two distinct classes of cortical nodes form separately during interphase in fission yeast cells and then merge at the cell equator by a diffuse-and-capture mechanism to prepare nodes to form the contractile ring for cytokinesis.
The Ustilago maydis Hook protein Hok1 is part of an evolutionarily conserved protein complex that regulates bidirectional early endosome trafficking by controlling attachment of both kinesin-3 and dynein.
During chemotactic movement, D. discoideum exhibits step-wise amoeboid motility driven by both contractile axial forces and lateral forces.
KLF4 controls bone homeostasis by negatively regulating both osteoclast and osteoblast differentiation.