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  • Cover Image

    Cover Image

    issue cover

    On the cover
    A chemotaxing Dictyostelium cell (gray) forms stationary “traction adhesions” along its anterior-posterior axis that transmit force (indicated by heat map) to the underlying substrate and allow the cell to move. The colored cylinder shows the path of the migrating cell over time.
    Image © 2014 Bastounis et al.
    See page 1045.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Two studies identify a linker protein that coordinates endosome motility by recruiting microtubule-based motors.

People & Ideas

Barral studies the regulation of cell growth and aging in yeast.

Review

Quality control

Report

The role of Greatwall kinase in autoregulatory activation of cyclin B–Cdk1 at M phase onset can be bypassed by cyclin B–Cdk1–mediated direct phosphorylation of Arpp19, leading to PP2A-B55 inhibition.

MAPK and Cdk1 play compensatory roles in suppressing APC/C activity early in prometaphase, thereby allowing accumulation of APC/C substrates essential for meiosis I.

Mad1 recruitment to metaphase kinetochores reactivates the mitotic checkpoint, which requires the C terminus of Mad1 in addition to its Mad2-binding domain.

The E3 ligase Ltn1 and the deubiquitylase Ubp3-Bre5 titrate the level of ribosomal subunit ubiquitylation and thereby set the rate of ribosomal protein degradation by ribophagy in response to nutrient supply and the level of protein translation.

OPA1 processing by YEM1L and OMA1 is dispensable for mitochondrial fusion and instead drives mitochondrial fragmentation, which is crucial for mitochondrial integrity and quality control.

Article

PML multimerization into nuclear bodies following its oxidation promotes sumoylation and sequestration of partner proteins in these structures.

EB1 enables spindle microtubules to regulate the phosphorylation of kinetochores through recruitment of Aurora B kinase.

The depolymerase activity of Kip3 suppresses spindle microtubule polymerization to limit spindle midzone length and prevent microtubule buckling in response to sliding forces.

Two distinct classes of cortical nodes form separately during interphase in fission yeast cells and then merge at the cell equator by a diffuse-and-capture mechanism to prepare nodes to form the contractile ring for cytokinesis.

The Ustilago maydis Hook protein Hok1 is part of an evolutionarily conserved protein complex that regulates bidirectional early endosome trafficking by controlling attachment of both kinesin-3 and dynein.

HookA is a novel linker protein that binds to endosomes and to dynein–dynactin and promotes dynein–early endosome interaction in Aspergillus.

In Dictyostelium, mechanical resistance induces bleb-driven chemotactic movement that is controlled through PI3-kinase.

During chemotactic movement, D. discoideum exhibits step-wise amoeboid motility driven by both contractile axial forces and lateral forces.

KLF4 controls bone homeostasis by negatively regulating both osteoclast and osteoblast differentiation.

Correction

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