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In This Issue

In Focus

Protein halts modification of glycoproteins, encouraging germ cells to stay tight.

People & Ideas

Bettencourt-Dias studies the structures underlying both cilia and the mitotic spindle.


We are pleased to welcome several new JCB editorial board members.



The CHD4 helicase is identified as a new component of the genome surveillance machinery in a proteomic screen for factors enriched on chromatin after ionizing radiation (see also related paper by Smeenk et al. in this issue).

NuRD is recruited to DNA double-strand breaks, where it promotes RNF8/RNF168 histone ubiquitylation and accumulation of DNA repair factors (see also related paper by Larsen et al. in this issue).

Recruitment of the Crumbs–Stardust polarity complex depends on interactions between Bazooka and the Stardust PDZ domain and is regulated by aPKC-mediated phosphorylation.


Folding of gene loci organized in tandem arrays reveals variation of chromatin structure as a function of cell differentiation.

The expression of a new histone variant H3.Y increases during cellular stress to regulate cell cycle progression and gene expression.

The SIN pathway blocks inappropriate actin rearrangements during cytokinesis by preventing activation of the MOR pathway component Orb6.

Phosphorylation of the Ran GTPase on Serine-135 by PAK4 changes Ran’s association with its regulatory proteins and its ability to induce microtubule asters.

MIND–Mis12 bridges the microtubule receptor complex and the inner kinetochore (see also a related paper by Petrovic et al. in this issue).

The NSL1 subunit structures interactions between the MIS12, NDC80, and KNL1 kinetochore complexes (see also a related paper by Maskell et al. in this issue).

Subsets of 40S ribosomal subunits are required for initiating rRNA processing, rRNA maturation, and nuclear export.

Pax7 is a target of two miRNAs that are induced during muscle satellite cell differentiation and repressed in response to muscle injury.

In Special Collection:
JCB65: Autophagy

HMGB1 displaces Bcl-2 from Beclin1 to induce and sustain autophagy in response to cell stress.

GnT1IP inhibits GlcNAcT-1 to change N-glycosylation patterns on secretory proteins, potentially regulating germ cell adhesion to Sertoli cells during spermatogenesis.

Accumulation of the GABA inhibitory neurotransmitter for rapid delivery into synapses can be accomplished by GAD65 dependent and independent membrane-targeting of GAD67.

Entry and exit of proteins into flagella is gauged by CEP290 in the transition zone.


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