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Cover Image
Cover Image
On the cover
Wiedemann et al. identify two novel variants of histone H3. Super-resolution 3D-SIM microscopy of a starved U20S cell shows that these histones (green) mainly localize to regions where chromatin (blue) is less condensed. A conventional wide-field image of the same nucleus is at the top right.
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In This Issue
In Focus
Sweet recipe for cellular closeness
Protein halts modification of glycoproteins, encouraging germ cells to stay tight.
People & Ideas
Mónica Bettencourt-Dias: Centered on centrioles
Bettencourt-Dias studies the structures underlying both cilia and the mitotic spindle.
Editorial
New editorial board members
We are pleased to welcome several new JCB editorial board members.
Review
Report
The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage
The CHD4 helicase is identified as a new component of the genome surveillance machinery in a proteomic screen for factors enriched on chromatin after ionizing radiation (see also related paper by Smeenk et al. in this issue).
The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage
NuRD is recruited to DNA double-strand breaks, where it promotes RNF8/RNF168 histone ubiquitylation and accumulation of DNA repair factors (see also related paper by Larsen et al. in this issue).
Formation of a Bazooka–Stardust complex is essential for plasma membrane polarity in epithelia
Recruitment of the Crumbs–Stardust polarity complex depends on interactions between Bazooka and the Stardust PDZ domain and is regulated by aPKC-mediated phosphorylation.
Article
Dynamic plasticity of large-scale chromatin structure revealed by self-assembly of engineered chromosome regions
Folding of gene loci organized in tandem arrays reveals variation of chromatin structure as a function of cell differentiation.
Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y
The expression of a new histone variant H3.Y increases during cellular stress to regulate cell cycle progression and gene expression.
The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe
The SIN pathway blocks inappropriate actin rearrangements during cytokinesis by preventing activation of the MOR pathway component Orb6.
Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis
Phosphorylation of the Ran GTPase on Serine-135 by PAK4 changes Ran’s association with its regulatory proteins and its ability to induce microtubule asters.
Molecular architecture and assembly of the yeast kinetochore MIND complex
MIND–Mis12 bridges the microtubule receptor complex and the inner kinetochore (see also a related paper by Petrovic et al. in this issue).
The MIS12 complex is a protein interaction hub for outer kinetochore assembly
The NSL1 subunit structures interactions between the MIS12, NDC80, and KNL1 kinetochore complexes (see also a related paper by Maskell et al. in this issue).
Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits
Subsets of 40S ribosomal subunits are required for initiating rRNA processing, rRNA maturation, and nuclear export.
microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7
Pax7 is a target of two miRNAs that are induced during muscle satellite cell differentiation and repressed in response to muscle injury.
Endogenous HMGB1 regulates autophagy
HMGB1 displaces Bcl-2 from Beclin1 to induce and sustain autophagy in response to cell stress.
A testis-specific regulator of complex and hybrid N-glycan synthesis
GnT1IP inhibits GlcNAcT-1 to change N-glycosylation patterns on secretory proteins, potentially regulating germ cell adhesion to Sertoli cells during spermatogenesis.
Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters
Accumulation of the GABA inhibitory neurotransmitter for rapid delivery into synapses can be accomplished by GAD65 dependent and independent membrane-targeting of GAD67.
CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content
Entry and exit of proteins into flagella is gauged by CEP290 in the transition zone.
