In the twelfth collection celebrating our 65th anniversary, we rediscover studies that shaped our understanding of the molecular principles of autophagy and its role in disease. Many fundamental studies of the autophagy machinery in yeast as well as more recent work across systems—on mitophagy in particular—were published in JCB. Find more content about the regulation and molecular mechanisms of this pathway as well as its physiological role in vivo and in disease contexts. If we missed your favorite JCB study, tweet to @JCellBiol using the hashtag #JCB65, or email us at email@example.com. Find more 65th anniversary collections or browse our From the Archive series.
Image from Takeshige et al., 1992.