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    Electron microscopy of a budding yeast cell illustrates the de novo biogenesis of double-membraned vesicles used for autophagy and the related Cvt pathway. A cluster of vesicles and tubules forms around an electron-dense structure corresponding to the Cvt complex, which contains aminopeptidase I oligomers destined for the yeast vacuole.
    See page 1005.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Wnt signaling component is removed from active duty by exosomes.

People & Ideas

Mizushima explores the physiological roles of self-eating.

Review

Review series

Report

Cdc48/p97/VCP plays a ubiquitin-independent role during autophagosome formation in S. cerevisiae.

Article

Elm1 phosphorylates a conserved residue within the Kin4 kinase domain to coordinate spindle position with cell cycle progression.

The product of the von Hippel-Lindau tumor suppressor gene stabilizes microtubules by inhibiting GTPase activity.

A reservoir of Atg9-containing vesicles and tubules provides the initial membranes necessary for autophagophore formation in yeast.

α-Synuclein impairs autophagosome formation and mislocalizes Atg9 by inhibiting Rab1a.

Self- and hetero-association of the pro-apoptotic proteins Reaper, Hid, and Grim is required for efficient induction of the cell death program.

The PI3K isoform p110δ is required for TNF trafficking and secretion.

The calcium-dependent activator proteins for secretion, CAPS1 and CAPS2, facilitate syntaxin opening during synaptic vesicle priming.

The tetraspanins CD9 and CD82 suppress Wnt signaling by promoting the discharge of β-catenin from cells.

Both the osteoblast-specific osteocalcin gene and collagen 1α2 are targets of the transcription factor Fra-2, which controls bone formation.

Extracellular microfibrils composed of fibrillin-1 and -2 regulate bone formation through modulation of TGF-β and BMP signaling.

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