On the cover
Electron microscopy of a budding yeast cell illustrates the de novo biogenesis of double-membraned vesicles used for autophagy and the related Cvt pathway. A cluster of vesicles and tubules forms around an electron-dense structure corresponding to the Cvt complex, which contains aminopeptidase I oligomers destined for the yeast vacuole.
See page 1005.
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People & Ideas
Cdc48/p97/VCP plays a ubiquitin-independent role during autophagosome formation in S. cerevisiae.
The product of the von Hippel-Lindau tumor suppressor gene stabilizes microtubules by inhibiting GTPase activity.
A reservoir of Atg9-containing vesicles and tubules provides the initial membranes necessary for autophagophore formation in yeast.
α-Synuclein impairs autophagosome formation and mislocalizes Atg9 by inhibiting Rab1a.
Self- and hetero-association of the pro-apoptotic proteins Reaper, Hid, and Grim is required for efficient induction of the cell death program.
Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion
The PI3K isoform p110δ is required for TNF trafficking and secretion.
The calcium-dependent activator proteins for secretion, CAPS1 and CAPS2, facilitate syntaxin opening during synaptic vesicle priming.
Both the osteoblast-specific osteocalcin gene and collagen 1α2 are targets of the transcription factor Fra-2, which controls bone formation.
Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation
Extracellular microfibrils composed of fibrillin-1 and -2 regulate bone formation through modulation of TGF-β and BMP signaling.