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New parts in beating hearts

Amy Maxmen
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Dendritic cells teach tolerance

Amy Maxmen
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Flagging Th17 in Crohn's

Amy Maxmen
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TSLP calms inflammation

Amy Maxmen
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A syndecan-based tumor stopper

Amy Maxmen
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People & Ideas

Clifton E. Barry, III: TB's strategic opponent

Amy Maxmen

Leaping from the periodic table to the petri dish, from clinical studies to policy, Clif Barry battles the obstacles involved in eradicating tuberculosis (TB) from multiple fronts.

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Brief Definitive Report

Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves

Jae-Hoon Choi,Yoonkyung Do,Cheolho Cheong,Hyein Koh,Silvia B. Boscardin,Yong-Seok Oh,Leonia Bozzacco,Christine Trumpfheller,Chae Gyu Park,Ralph M. Steinman
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A novel myelin P0–specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy

Cédric Louvet,Beniwende G. Kabre,Dan W. Davini,Nicolas Martinier,Maureen A. Su,Jason J. DeVoss,Wendy L. Rosenthal,Mark S. Anderson,Hélène Bour-Jordan,Jeffrey A. Bluestone
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Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response

Agnieszka Kielczewska,Michal Pyzik,Tianhe Sun,Astrid Krmpotic,Melissa B. Lodoen,Michael W. Munks,Marina Babic,Ann B. Hill,Ulrich H. Koszinowski,Stipan Jonjic,Lewis L. Lanier,Silvia M. Vidal
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Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

Melanie A. Kleinschek,Katia Boniface,Svetlana Sadekova,Jeff Grein,Erin E. Murphy,Scott P. Turner,Lisa Raskin,Bela Desai,William A. Faubion,Rene de Waal Malefyt,Robert H. Pierce,Terrill McClanahan,Robert A. Kastelein
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Article

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

Katia Boniface,Kristian S. Bak-Jensen,Ying Li,Wendy M. Blumenschein,Mandy J. McGeachy,Terrill K. McClanahan,Brent S. McKenzie,Robert A. Kastelein,Daniel J. Cua,René de Waal Malefyt
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Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

Caspar Ohnmacht,Andrea Pullner,Susan B.S. King,Ingo Drexler,Stefanie Meier,Thomas Brocker,David Voehringer
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Follicular helper T cells are required for systemic autoimmunity

Michelle A. Linterman,Robert J. Rigby,Raphael. K. Wong,Di Yu,Robert Brink,Jennifer L. Cannons,Pamela L. Schwartzberg,Matthew C. Cook,Giles D. Walters,Carola G. Vinuesa
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Critical role of phospholipase Cγ2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis

Zoltán Jakus,Edina Simon,David Frommhold,Markus Sperandio,Attila Mócsai
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CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation

Cedric Auffray,Darin K. Fogg,Emilie Narni-Mancinelli,Brigitte Senechal,Celine Trouillet,Noah Saederup,Julia Leemput,Karine Bigot,Laura Campisi,Marc Abitbol,Thierry Molina,Israel Charo,David A. Hume,Ana Cumano,Gregoire Lauvau,Frederic Geissmann
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Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus

JiChu Li,JooHung Park,Deborah Foss,Irving Goldschneider
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The adhesion molecule L1 regulates transendothelial migration and trafficking of dendritic cells

Luigi Maddaluno,Sue Ellen Verbrugge,Chiara Martinoli,Gianluca Matteoli,Andrea Chiavelli,Yiping Zeng,Elizabeth D. Williams,Maria Rescigno,Ugo Cavallaro
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Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36

Terry K. Means,Eleftherios Mylonakis,Emmanouil Tampakakis,Richard A. Colvin,Edward Seung,Lindsay Puckett,Melissa F. Tai,Cameron R. Stewart,Read Pukkila-Worley,Suzanne E. Hickman,Kathryn J. Moore,Stephen B. Calderwood,Nir Hacohen,Andrew D. Luster,Joseph El Khoury
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TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis

Betsy C. Taylor,Colby Zaph,Amy E. Troy,Yurong Du,Katherine J. Guild,Michael R. Comeau,David Artis
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MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

Beth A. Helmink,Andrea L. Bredemeyer,Baeck-Seung Lee,Ching-Yu Huang,Girdhar G. Sharma,Laura M. Walker,Jeffrey J. Bednarski,Wan-Ling Lee,Tej K. Pandita,Craig H. Bassing,Barry P. Sleckman
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PLC-γ2 is essential for formation and maintenance of memory B cells

Masaki Hikida,Stefano Casola,Noriko Takahashi,Tomohiro Kaji,Toshitada Takemori,Klaus Rajewsky,Tomohiro Kurosaki
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Syndecan-1 regulates αvβ3 and αvβ5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor

DeannaLee M. Beauvais,Brian J. Ell,Andrea R. McWhorter,Alan C. Rapraeger
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Cytosolic PLA2 is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15

Fangming Tang,Zhangguo Chen,Cezary Ciszewski,Mala Setty,Jason Solus,Maria Tretiakova,Ellen Ebert,Jin Han,Anning Lin,Stefano Guandalini,Veronika Groh,Thomas Spies,Peter Green,Bana Jabri
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Correction

CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

Randall H. Friedline,David S. Brown,Hai Nguyen,Hardy Kornfeld,JinHee Lee,Yi Zhang,Mark Appleby,Sandy D. Der,Joonsoo Kang,Cynthia A. Chambers
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New twist on the regulation of NKG2D ligand expression

Adelheid Cerwenka
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