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Issues

Volume 206, Issue 4
13 April 2009
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  • Cover Image

    Cover Image

    issue cover

    ON THE COVER
    A neuroblastoma in psuedocolor. These tumors produce a protein called netrin-1, which promotes tumor cell survival and is correlated with poor prognosis in patients. Related article by Delloye-Bourgeois et al.
    See page 833

  • PDF Icon PDF LinkTable of Contents
  • PDF Icon PDF LinkEditorial Board
ISSN 0022-1007
EISSN 1540-9538

In This Issue

Immune understudies combat lupus
Mitch Leslie
View Articletitled, Immune understudies combat lupus
Flipping the cancer switch
Mitch Leslie
View Articletitled, Flipping the cancer switch
Save yourself, cancer cell
Mitch Leslie
View Articletitled, Save yourself, cancer cell
Lasting T reg cell–mediated protection
Mitch Leslie
View Articletitled, Lasting T reg cell–mediated protection
HIV's cost/benefit analysis
Mitch Leslie
View Articletitled, HIV's cost/benefit analysis

People & Ideas

Dana Philpott: Exploring the land of NOD
Kira Heller

Scientist and mom Dana Philpott has dedicated her career to figuring out how mammalian NOD-like receptors detect invading pathogens and help prevent autoimmune disorders such as Crohn's disease.

View Articletitled, Dana Philpott: Exploring the land of NOD

Commentary

Settling the thymus: immigration requirements
Jason G. Cyster
View Articletitled, Settling the thymus: immigration requirements

Brief Definitive Report

The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function
Michela Locci,Elena Draghici,Francesco Marangoni,Marita Bosticardo,Marco Catucci,Alessandro Aiuti,Caterina Cancrini,Laszlo Marodi,Teresa Espanol,Robbert G.M. Bredius,Adrian J. Thrasher,Ansgar Schulz,Jiri Litzman,Maria Grazia Roncarolo,Giulia Casorati,Paolo Dellabona,Anna Villa
View Articletitled, The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function
A role for human skin–resident T cells in wound healing
Antoine Toulon,Lionel Breton,Kristen R. Taylor,Mayer Tenenhaus,Dhaval Bhavsar,Caroline Lanigan,Ross Rudolph,Julie Jameson,Wendy L. Havran
View Articletitled, A role for human skin–resident T cells in wound healing
In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression
Kylie E. Webster,Stacey Walters,Rachel E. Kohler,Tomas Mrkvan,Onur Boyman,Charles D. Surh,Shane T. Grey,Jonathan Sprent
View Articletitled, In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

Article

Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25
Klaus Gossens,Silvia Naus,Stephane Y. Corbel,Shujun Lin,Fabio M.V. Rossi,Jürgen Kast,Hermann J. Ziltener
View Articletitled, Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25
CSL–MAML-dependent Notch1 signaling controls T lineage–specific IL-7Rα gene expression in early human thymopoiesis and leukemia
Sara González-García,Marina García-Peydró,Enrique Martín-Gayo,Esteban Ballestar,Manel Esteller,Rafael Bornstein,José Luis de la Pompa,Adolfo A. Ferrando,María L. Toribio
View Articletitled, CSL–MAML-dependent Notch1 signaling controls T lineage–specific IL-7Rα gene expression in early human thymopoiesis and leukemia
Normally occurring NKG2D+CD4+ T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus
Zhenpeng Dai,Cameron J. Turtle,Garrett C. Booth,Stanley R. Riddell,Theodore A. Gooley,Anne M. Stevens,Thomas Spies,Veronika Groh
View Articletitled, Normally occurring NKG2D<sup>+</sup>CD4<sup>+</sup> T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus
Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection
Mark T. Orr,Joseph C. Sun,David G.T. Hesslein,Hisashi Arase,Joseph H. Phillips,Toshiyuki Takai,Lewis L. Lanier
View Articletitled, Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection
Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-β and STAT3 activation
Atsushi Hosui,Akiko Kimura,Daisuke Yamaji,Bing-mei Zhu,Risu Na,Lothar Hennighausen
View Articletitled, Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-β and STAT3 activation
Netrin-1 acts as a survival factor for aggressive neuroblastoma
Céline Delloye-Bourgeois,Julien Fitamant,Andrea Paradisi,David Cappellen,Setha Douc-Rasy,Marie-Anne Raquin,Dwayne Stupack,Akira Nakagawara,Raphaël Rousseau,Valérie Combaret,Alain Puisieux,Dominique Valteau-Couanet,Jean Bénard,Agnès Bernet,Patrick Mehlen
View Articletitled, Netrin-1 acts as a survival factor for aggressive neuroblastoma
Self-antigen–specific CD8+ T cell precursor frequency determines the quality of the antitumor immune response
Gabrielle A. Rizzuto,Taha Merghoub,Daniel Hirschhorn-Cymerman,Cailian Liu,Alexander M. Lesokhin,Diana Sahawneh,Hong Zhong,Katherine S. Panageas,Miguel-Angel Perales,Grégoire Altan-Bonnet,Jedd D. Wolchok,Alan N. Houghton
View Articletitled, Self-antigen–specific CD8<sup>+</sup> T cell precursor frequency determines the quality of the antitumor immune response
Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance
Noemi Soto-Nieves,Irene Puga,Brian T. Abe,Sanmay Bandyopadhyay,Ian Baine,Anjana Rao,Fernando Macian
View Articletitled, Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance
Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse
Roberto A. Maldonado,Michelle A. Soriano,L. Carolina Perdomo,Kirsten Sigrist,Darrell J. Irvine,Thomas Decker,Laurie H. Glimcher
View Articletitled, Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse
Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability
Ying Huang,William Giblin,Martina Kubec,Gerwin Westfield,Jordan St. Charles,Laurel Chadde,Stephanie Kraftson,JoAnn Sekiguchi
View Articletitled, Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability
Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703–positive individuals and their transmission recipients
Hayley Crawford,Wendy Lumm,Alasdair Leslie,Malinda Schaefer,Debrah Boeras,Julia G. Prado,Jianming Tang,Paul Farmer,Thumbi Ndung'u,Shabir Lakhi,Jill Gilmour,Paul Goepfert,Bruce D. Walker,Richard Kaslow,Joseph Mulenga,Susan Allen,Philip J.R. Goulder,Eric Hunter
View Articletitled, Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703–positive individuals and their transmission recipients
Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection
David A. Price,Tedi E. Asher,Nancy A. Wilson,Martha C. Nason,Jason M. Brenchley,Ian S. Metzler,Vanessa Venturi,Emma Gostick,Pratip K. Chattopadhyay,Mario Roederer,Miles P. Davenport,David I. Watkins,Daniel C. Douek
View Articletitled, Public clonotype usage identifies protective Gag-specific CD8<sup>+</sup> T cell responses in SIV infection
Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung
Meera G. Nair,Yurong Du,Jacqueline G. Perrigoue,Colby Zaph,Justin J. Taylor,Michael Goldschmidt,Gary P. Swain,George D. Yancopoulos,David M. Valenzuela,Andrew Murphy,Margaret Karow,Sean Stevens,Edward J. Pearce,David Artis
View Articletitled, Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung
Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites
Alexandre Bougdour,Danièle Maubon,Patricia Baldacci,Philippe Ortet,Olivier Bastien,Anthony Bouillon,Jean-Christophe Barale,Hervé Pelloux,Robert Ménard,Mohamed-Ali Hakimi
View Articletitled, Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites

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