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In This Issue

Immune understudies combat lupus

Mitch Leslie
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Flipping the cancer switch

Mitch Leslie
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Save yourself, cancer cell

Mitch Leslie
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Lasting T reg cell–mediated protection

Mitch Leslie
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HIV's cost/benefit analysis

Mitch Leslie
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People & Ideas

Dana Philpott: Exploring the land of NOD

Kira Heller

Scientist and mom Dana Philpott has dedicated her career to figuring out how mammalian NOD-like receptors detect invading pathogens and help prevent autoimmune disorders such as Crohn's disease.

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Commentary

Settling the thymus: immigration requirements

Jason G. Cyster
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Brief Definitive Report

The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function

Michela Locci,Elena Draghici,Francesco Marangoni,Marita Bosticardo,Marco Catucci,Alessandro Aiuti,Caterina Cancrini,Laszlo Marodi,Teresa Espanol,Robbert G.M. Bredius,Adrian J. Thrasher,Ansgar Schulz,Jiri Litzman,Maria Grazia Roncarolo,Giulia Casorati,Paolo Dellabona,Anna Villa
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A role for human skin–resident T cells in wound healing

Antoine Toulon,Lionel Breton,Kristen R. Taylor,Mayer Tenenhaus,Dhaval Bhavsar,Caroline Lanigan,Ross Rudolph,Julie Jameson,Wendy L. Havran
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In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

Kylie E. Webster,Stacey Walters,Rachel E. Kohler,Tomas Mrkvan,Onur Boyman,Charles D. Surh,Shane T. Grey,Jonathan Sprent
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Article

Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25

Klaus Gossens,Silvia Naus,Stephane Y. Corbel,Shujun Lin,Fabio M.V. Rossi,Jürgen Kast,Hermann J. Ziltener
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CSL–MAML-dependent Notch1 signaling controls T lineage–specific IL-7Rα gene expression in early human thymopoiesis and leukemia

Sara González-García,Marina García-Peydró,Enrique Martín-Gayo,Esteban Ballestar,Manel Esteller,Rafael Bornstein,José Luis de la Pompa,Adolfo A. Ferrando,María L. Toribio
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Normally occurring NKG2D+CD4+ T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus

Zhenpeng Dai,Cameron J. Turtle,Garrett C. Booth,Stanley R. Riddell,Theodore A. Gooley,Anne M. Stevens,Thomas Spies,Veronika Groh
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Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection

Mark T. Orr,Joseph C. Sun,David G.T. Hesslein,Hisashi Arase,Joseph H. Phillips,Toshiyuki Takai,Lewis L. Lanier
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Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-β and STAT3 activation

Atsushi Hosui,Akiko Kimura,Daisuke Yamaji,Bing-mei Zhu,Risu Na,Lothar Hennighausen
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Netrin-1 acts as a survival factor for aggressive neuroblastoma

Céline Delloye-Bourgeois,Julien Fitamant,Andrea Paradisi,David Cappellen,Setha Douc-Rasy,Marie-Anne Raquin,Dwayne Stupack,Akira Nakagawara,Raphaël Rousseau,Valérie Combaret,Alain Puisieux,Dominique Valteau-Couanet,Jean Bénard,Agnès Bernet,Patrick Mehlen
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Self-antigen–specific CD8+ T cell precursor frequency determines the quality of the antitumor immune response

Gabrielle A. Rizzuto,Taha Merghoub,Daniel Hirschhorn-Cymerman,Cailian Liu,Alexander M. Lesokhin,Diana Sahawneh,Hong Zhong,Katherine S. Panageas,Miguel-Angel Perales,Grégoire Altan-Bonnet,Jedd D. Wolchok,Alan N. Houghton
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Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance

Noemi Soto-Nieves,Irene Puga,Brian T. Abe,Sanmay Bandyopadhyay,Ian Baine,Anjana Rao,Fernando Macian
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Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse

Roberto A. Maldonado,Michelle A. Soriano,L. Carolina Perdomo,Kirsten Sigrist,Darrell J. Irvine,Thomas Decker,Laurie H. Glimcher
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Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability

Ying Huang,William Giblin,Martina Kubec,Gerwin Westfield,Jordan St. Charles,Laurel Chadde,Stephanie Kraftson,JoAnn Sekiguchi
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Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703–positive individuals and their transmission recipients

Hayley Crawford,Wendy Lumm,Alasdair Leslie,Malinda Schaefer,Debrah Boeras,Julia G. Prado,Jianming Tang,Paul Farmer,Thumbi Ndung'u,Shabir Lakhi,Jill Gilmour,Paul Goepfert,Bruce D. Walker,Richard Kaslow,Joseph Mulenga,Susan Allen,Philip J.R. Goulder,Eric Hunter
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Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection

David A. Price,Tedi E. Asher,Nancy A. Wilson,Martha C. Nason,Jason M. Brenchley,Ian S. Metzler,Vanessa Venturi,Emma Gostick,Pratip K. Chattopadhyay,Mario Roederer,Miles P. Davenport,David I. Watkins,Daniel C. Douek
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Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung

Meera G. Nair,Yurong Du,Jacqueline G. Perrigoue,Colby Zaph,Justin J. Taylor,Michael Goldschmidt,Gary P. Swain,George D. Yancopoulos,David M. Valenzuela,Andrew Murphy,Margaret Karow,Sean Stevens,Edward J. Pearce,David Artis
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Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites

Alexandre Bougdour,Danièle Maubon,Patricia Baldacci,Philippe Ortet,Olivier Bastien,Anthony Bouillon,Jean-Christophe Barale,Hervé Pelloux,Robert Ménard,Mohamed-Ali Hakimi
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