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Cover Image
Cover Image
On the cover
30 min after injury, activated Src family kinases (green) and ERK (magenta) are apparent in the epithelium of a wounded zebrafish tail fin. Yoo et al. demonstrate that these early signaling events, as well as a short burst of intracellular calcium release, are required for the regeneration of the fin several days later.
Image © 2012 Yoo et al.
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In This Issue
In Focus
Fyn regeneration
A Src family kinase and several other signaling pathways help repair zebrafish fins after wounding.
People & Ideas
Laurie Boyer: Stem cell circuitry for commitment
Boyer studies the genetic programs governing lineage commitment in pluripotent stem cells.
Feature
Review
Report
The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1+/− mice
MCLK1 and COQ3 are mitochondrial enzymes necessary for ubiquinone biosynthesis, but only MCLK1 also regulates the partitioning of ubiquinone between mitochondrial membranes and affects longevity in mice.
Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish
Redox, SFK, and calcium signaling are immediate “wound signals” that integrate early wound responses and late epimorphic regeneration.
Article
PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1
PARP1-mediated poly(ADP-ribosyl)ation of DDB2 prolongs its occupation on UV-damaged chromatin and promotes the recruitment of the chromatin remodeler ALC1.
Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation
Haspin inhibitors reveal that Aurora B at centromeres is required for metaphase chromosome alignment and spindle checkpoint signaling.
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
A chemical biology study characterizes the role of Haspin kinase in centromere recruitment of the chromosome passenger complex and in spindle assembly checkpoint function.
Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore–microtubule attachments
Cdk1 phosphorylation of CLASP2 promotes Plk1 recruitment to kinetochores and is required for stabilization of kinetochore–microtubule attachments, chromosome alignment, and satisfaction of the spindle assembly checkpoint.
Co-operation between different targeting pathways during integration of a membrane protein
The Sec and Tat pathways are both required to insert the three hydrophobic domains of the Rieske protein into the membrane.
Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector
The Ras association and PH domains of RIAM function as a proximity detector for activated Rap1 and PI(4,5)P2.
Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration
The PAR complex targets Tiam1 to adhesions, where it interacts with talin to promote adhesion-induced Rac1 activation, cell spreading, and migration.
miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration
A differentiation-promoting micro-RNA regulates actin cable dynamics, intercellular adhesion, and cell migration in human and mouse epidermis.
p120-catenin binding masks an endocytic signal conserved in classical cadherins
p120 regulates adhesive junction dynamics through binding to a dual-function motif in classical cadherins that alternately serves as a p120-binding interface and an endocytic signal.
Localization of Usher 1 proteins to the photoreceptor calyceal processes, which are absent from mice
Mice are a poor model for retinal defects caused by type I Usher syndrome (USH1) because their photoreceptors have almost no calyceal processes, the structures in which all USH1 proteins are detected in other vertebrates.
