On the cover
30 min after injury, activated Src family kinases (green) and ERK (magenta) are apparent in the epithelium of a wounded zebrafish tail fin. Yoo et al. demonstrate that these early signaling events, as well as a short burst of intracellular calcium release, are required for the regeneration of the fin several days later.
Image © 2012 Yoo et al.
See page 225.
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MCLK1 and COQ3 are mitochondrial enzymes necessary for ubiquinone biosynthesis, but only MCLK1 also regulates the partitioning of ubiquinone between mitochondrial membranes and affects longevity in mice.
Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish
Redox, SFK, and calcium signaling are immediate “wound signals” that integrate early wound responses and late epimorphic regeneration.
PARP1-mediated poly(ADP-ribosyl)ation of DDB2 prolongs its occupation on UV-damaged chromatin and promotes the recruitment of the chromatin remodeler ALC1.
Haspin inhibitors reveal that Aurora B at centromeres is required for metaphase chromosome alignment and spindle checkpoint signaling.
A chemical biology study characterizes the role of Haspin kinase in centromere recruitment of the chromosome passenger complex and in spindle assembly checkpoint function.
Cdk1 phosphorylation of CLASP2 promotes Plk1 recruitment to kinetochores and is required for stabilization of kinetochore–microtubule attachments, chromosome alignment, and satisfaction of the spindle assembly checkpoint.
The Sec and Tat pathways are both required to insert the three hydrophobic domains of the Rieske protein into the membrane.
Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector
The Ras association and PH domains of RIAM function as a proximity detector for activated Rap1 and PI(4,5)P2.
Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration
The PAR complex targets Tiam1 to adhesions, where it interacts with talin to promote adhesion-induced Rac1 activation, cell spreading, and migration.
A differentiation-promoting micro-RNA regulates actin cable dynamics, intercellular adhesion, and cell migration in human and mouse epidermis.
p120 regulates adhesive junction dynamics through binding to a dual-function motif in classical cadherins that alternately serves as a p120-binding interface and an endocytic signal.
Localization of Usher 1 proteins to the photoreceptor calyceal processes, which are absent from mice
Mice are a poor model for retinal defects caused by type I Usher syndrome (USH1) because their photoreceptors have almost no calyceal processes, the structures in which all USH1 proteins are detected in other vertebrates.