In This Issue
People & Ideas
Phosphocaveolin-1 is a mechanotransducer that induces caveola biogenesis via Egr1 transcriptional regulation
Phosphocaveolin-1 regulates a positive feedback loop that responds to mechanical stress to induce caveola biogenesis by relieving Egr1 transcriptional inhibition of caveolin-1 and cavin-1.
STAT3, an intracellular mediator of the effects of CNTF and other neurotrophic cytokines, has a distinct cytoplasmic function in inhibiting microtubule depolymerization in axons of motoneurons.
Rbms3 regulates TGF-βr signaling, a critical pathway for chondrogenesis, by binding and stabilizing Smad2 transcripts.
KIF3A is important for the intracellular transport of HIV-containing compartments and HIV release from infected macrophages.
TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals
TspanC8 tetraspanins have a conserved function in the regulation of ADAM10 trafficking and activity, thereby positively regulating Notch activation.
Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells
A biomembrane force probe visualizes force-regulated reversible switches between bent and extended conformations of αLβ2 integrin on the surface of a living cell.
Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation
Noncentrosomal microtubules recruit myosin II to the cell cortex in order to engage adherens junctions and increase tight junction formation, resulting in an increase in mechanical integrity of cell sheets.
N-WASP is critical for cancer cell invasion through its promotion of the trafficking and capture of MT1-MMP in invasive pseudopods.
Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility
Coupling of the mechanical microenvironment with contractile forces between neighboring cells regulates collective migration.