-
Cover Image
Cover Image
On the cover
Macrophages infected with HIV-1 (green) develop into giant cells with multiple nuclei (blue) and highly organized networks of microtubules (red) and actin (cyan). Gaudin et al. reveal that the microtubule-based kinesin motor KIF3A is important for the intracellular transport of virus-containing compartments and for the release of HIV-1 from infected macrophages.
Image © 2012 Gaudin et al.
See page 467. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
In This Issue
In Focus
Stay-at-home transcription factor saves axons
Without departing for the nucleus, STAT3 stabilizes microtubules.
People & Ideas
Fumiyo Ikeda: Ubiquitin lines up for action
Ikeda is studying the biological significance of linear ubiquitin chains.
Feature
Review
Report
Phosphocaveolin-1 is a mechanotransducer that induces caveola biogenesis via Egr1 transcriptional regulation
Phosphocaveolin-1 regulates a positive feedback loop that responds to mechanical stress to induce caveola biogenesis by relieving Egr1 transcriptional inhibition of caveolin-1 and cavin-1.
Article
Local axonal function of STAT3 rescues axon degeneration in the pmn model of motoneuron disease
STAT3, an intracellular mediator of the effects of CNTF and other neurotrophic cytokines, has a distinct cytoplasmic function in inhibiting microtubule depolymerization in axons of motoneurons.
Rbms3 functions in craniofacial development by posttranscriptionally modulating TGF-β signaling
Rbms3 regulates TGF-βr signaling, a critical pathway for chondrogenesis, by binding and stabilizing Smad2 transcripts.
Critical role for the kinesin KIF3A in the HIV life cycle in primary human macrophages
KIF3A is important for the intracellular transport of HIV-containing compartments and HIV release from infected macrophages.
TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals
TspanC8 tetraspanins have a conserved function in the regulation of ADAM10 trafficking and activity, thereby positively regulating Notch activation.
Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells
A biomembrane force probe visualizes force-regulated reversible switches between bent and extended conformations of αLβ2 integrin on the surface of a living cell.
Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation
Noncentrosomal microtubules recruit myosin II to the cell cortex in order to engage adherens junctions and increase tight junction formation, resulting in an increase in mechanical integrity of cell sheets.
N-WASP coordinates the delivery and F-actin–mediated capture of MT1-MMP at invasive pseudopods
N-WASP is critical for cancer cell invasion through its promotion of the trafficking and capture of MT1-MMP in invasive pseudopods.
Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility
Coupling of the mechanical microenvironment with contractile forces between neighboring cells regulates collective migration.
