In This Issue
People & Ideas
Isolation of the intact TOB complex reveals a 1:1:1 stoichiometry of Tob55, Tob38, and Tob37 with a 140-kD molecular mass, providing new insight into complex structure and function.
A novel motif in the yeast mitochondrial dynamin Dnm1 is essential for adaptor binding and membrane recruitment
A novel motif in the Insert B domain of the mitochondrial dynamin Dnm1 is essential for interaction with its adaptor Mdv1 during mitochondrial fission.
The distinct morphological and dynamic properties of their respective filaments suggest that FtsZ1 facilitates Z-ring remodeling, whereas FtsZ2 forms the Z-ring backbone during chloroplast division.
A flagellar A-kinase anchoring protein with two amphipathic helices forms a structural scaffold in the radial spoke complex
Amphipathic helices in the A-kinase anchoring protein RSP3 bind to spoke proteins involved in the assembly and modulation of the flagellar radial spoke complex, expanding the repertoire of these versatile helical protein motifs.
Cdc42 induces β1 integrin expression at the transcriptional level via the transcription factor SRF to promote cancer cell interaction with endothelial cells.
Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain
Cytoskeletal polarization occurs in response to mechanosensing of a transition from soft to stiff matrix during migration and promotes dephosphorylation of myosin-IIA, rearward localization of myosin-IIB, and durotaxis.
PATJ indirectly promotes apical–basal polarity in epithelial cells by enhancing Myosin phosphorylation and thereby stabilizing adherens junctions.
The C-terminal unique region of desmoglein 2 inhibits its internalization via tail–tail interactions
Tail–tail interactions of desmoglein 2, promoted by its C-terminal unique region, inhibit its internalization, stabilizing it at the cell surface and promoting intercellular adhesion.