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Cover Image
Cover Image
On the cover
Prostate cancer cells (yellow, left) extend multiple protrusions toward the endothelial cells (red) lining blood vessels in the mouse lung, whereas prostate cancer cells lacking Cdc42 (blue, right) remain rounded and show reduced spreading on the vessel walls. Reymond et al. reveal that Cdc42 promotes metastasis by inducing the expression of β1-integrin, boosting cancer cells' attachments to endothelial cells and the underlying basement membrane. Image © 2012 Reymond et al.
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In This Issue
In Focus
Cdc42 helps cancer cells make their exit
The Rho GTPase promotes metastasis by regulating the expression of β1 integrin.
People & Ideas
Gaudenz Danuser: The symphony of the cell
Danuser studies cytoskeletal dynamics, membrane trafficking, and cell migration.
Feature
Report
SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors
SUMOylation of the small GTPase ARL13 is required for the proper ciliary targeting of sensory receptors and corresponding sensory functions.
Article
Characterization of the insertase for β-barrel proteins of the outer mitochondrial membrane
Isolation of the intact TOB complex reveals a 1:1:1 stoichiometry of Tob55, Tob38, and Tob37 with a 140-kD molecular mass, providing new insight into complex structure and function.
A novel motif in the yeast mitochondrial dynamin Dnm1 is essential for adaptor binding and membrane recruitment
A novel motif in the Insert B domain of the mitochondrial dynamin Dnm1 is essential for interaction with its adaptor Mdv1 during mitochondrial fission.
Distinct functions of chloroplast FtsZ1 and FtsZ2 in Z-ring structure and remodeling
The distinct morphological and dynamic properties of their respective filaments suggest that FtsZ1 facilitates Z-ring remodeling, whereas FtsZ2 forms the Z-ring backbone during chloroplast division.
A flagellar A-kinase anchoring protein with two amphipathic helices forms a structural scaffold in the radial spoke complex
Amphipathic helices in the A-kinase anchoring protein RSP3 bind to spoke proteins involved in the assembly and modulation of the flagellar radial spoke complex, expanding the repertoire of these versatile helical protein motifs.
Cdc42 promotes transendothelial migration of cancer cells through β1 integrin
Cdc42 induces β1 integrin expression at the transcriptional level via the transcription factor SRF to promote cancer cell interaction with endothelial cells.
Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain
Cytoskeletal polarization occurs in response to mechanosensing of a transition from soft to stiff matrix during migration and promotes dephosphorylation of myosin-IIA, rearward localization of myosin-IIB, and durotaxis.
Drosophila PATJ supports adherens junction stability by modulating Myosin light chain activity
PATJ indirectly promotes apical–basal polarity in epithelial cells by enhancing Myosin phosphorylation and thereby stabilizing adherens junctions.
The C-terminal unique region of desmoglein 2 inhibits its internalization via tail–tail interactions
Tail–tail interactions of desmoglein 2, promoted by its C-terminal unique region, inhibit its internalization, stabilizing it at the cell surface and promoting intercellular adhesion.
