On the cover
A surface-rendered 3D image shows the distribution of the ryanodine receptor II (green) and inositol-(1,4,5) triphosphate receptor II (IP3RII, red) calcium channels in a cropped region of a rat ventricular cardiomyocyte. Drawnel et al. describe a positive feedback loop involving IP3RII and the microRNA miR-133a that promotes cardiomyocyte hypertrophy. Image © 2012 Drawnel et al.
See page 783.
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The cell biology of disease
Csi1 promotes centromere clustering by linking centromeres to the SUN domain protein Sad1 in the nuclear envelope.
A cortical myosin-dependent mechanism induces cell elongation to ensure clearance of trailing chromatids from the cleavage plane at the correct time during cytokinesis.
During the shaping of mitotic chromosomes, KIF4 and condensin work in parallel to promote lateral chromatid compaction and in opposition to topoisomerase IIα, which shortens the chromatid arms.
Rlp24 recruits Drg1 to pre-60S particles and stimulates its ATP hydrolysis to promote downstream maturation through specific extraction of Rlp24.
IP3RII-induced calcium release decreases miR-133a expression, which further increases IP3RII levels and calcium release and thereby promotes hypertrophic heart remodeling.
Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking
SIMPLE functions with the ESCRT machinery to promote endosome-to-lysosome trafficking, and this function is impaired by Charcot-Marie-Tooth disease–associated mutations.
The β2-adrenergic receptor antagonist carvedilol recruits MARCH2, a unique E3 ubiquitin ligase, to promote receptor endocytosis and lysosomal trafficking.
In addition to de novo F-actin assembly at the division site, directed transport of F-actin cables assembled elsewhere can contribute to actomyosin ring assembly during cytokinesis.
XMAP215msps and the EB1–Sentin duo act individually and cooperatively to accelerate microtubule growth and increase rescue events but also to promote frequent catastrophes.