In This Issue
People & Ideas
Although Munc13-1 and Munc13-2 facilitate dense-core vesicle fusion, they are not required for DCV release, in contrast to their essential role in synaptic vesicle exocytosis.
Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells
Variant repeats interspersed throughout ALT telomeres recruit nuclear receptors, leading to the destabilized telomere architecture and enhanced telomeric recombination.
A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function
An apolar patch and a polar cluster in the protein translocation channel cooperate to discriminate between signal sequences and less hydrophobic segments of cytosolic proteins.
Mobility of the SecA 2-helix-finger is not essential for polypeptide translocation via the SecYEG complex
Polypeptide translocation in bacteria, once underway, requires only one copy each of SecA and SecYEG and does not require the mobility of the SecA 2-helix-finger.
Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression
Mice expressing a version of Bub1 that lacks kinase activity have increased chromosome segregation errors and aneuploidy but not increased susceptibility to tumors.
The kinesin KIF14 associates with the PDZ domain of Radil and negatively regulates Rap1-mediated inside-out integrin activation by tethering Radil on microtubules.
Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells
Local cycling of LOK/SLK-dependent phosphorylation of ezrin is required for its apical localization and for microvillus formation.
The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization
Postsynaptic Farp1 helps to assemble a synaptic protein complex that promotes F-actin assembly and spine formation, and modulates active zones.
PI4KIIIα is targeted to the plasma membrane via an evolutionarily conserved complex comprised of EFR3 and TTC7 to control PtdIns4P synthesis and the selective enrichment of PtdIns(4,5)P2 in this membrane.