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Cover Image
Cover Image
On the cover
GFP-Farp1 (green) promotes the polymerization of F-actin (red) in dendritic spines, the postsynaptic protrusions of excitatory synapses. Cheadle and Biederer reveal that Farp1 works with the synaptic adhesion molecule SynCAM 1 to promote spine assembly and organize presynaptic active zones. The postsynaptic marker Shank is stained blue.
Image © 2012 Cheadle and Biederer.
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In This Issue
In Focus
Farp1 gives both sides of the story
Postsynaptic signaling protein helps organize both pre- and postsynapses.
People & Ideas
John Heuser: Capture the moment
Heuser uses quick-freeze, deep-etch electron microscopy to explore cellular ultrastructure.
Review
Report
Munc13 controls the location and efficiency of dense-core vesicle release in neurons
Although Munc13-1 and Munc13-2 facilitate dense-core vesicle fusion, they are not required for DCV release, in contrast to their essential role in synaptic vesicle exocytosis.
Article
Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells
Variant repeats interspersed throughout ALT telomeres recruit nuclear receptors, leading to the destabilized telomere architecture and enhanced telomeric recombination.
A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function
An apolar patch and a polar cluster in the protein translocation channel cooperate to discriminate between signal sequences and less hydrophobic segments of cytosolic proteins.
Mobility of the SecA 2-helix-finger is not essential for polypeptide translocation via the SecYEG complex
Polypeptide translocation in bacteria, once underway, requires only one copy each of SecA and SecYEG and does not require the mobility of the SecA 2-helix-finger.
Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression
Mice expressing a version of Bub1 that lacks kinase activity have increased chromosome segregation errors and aneuploidy but not increased susceptibility to tumors.
KIF14 negatively regulates Rap1a–Radil signaling during breast cancer progression
The kinesin KIF14 associates with the PDZ domain of Radil and negatively regulates Rap1-mediated inside-out integrin activation by tethering Radil on microtubules.
Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells
Local cycling of LOK/SLK-dependent phosphorylation of ezrin is required for its apical localization and for microvillus formation.
The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization
Postsynaptic Farp1 helps to assemble a synaptic protein complex that promotes F-actin assembly and spine formation, and modulates active zones.
PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity
PI4KIIIα is targeted to the plasma membrane via an evolutionarily conserved complex comprised of EFR3 and TTC7 to control PtdIns4P synthesis and the selective enrichment of PtdIns(4,5)P2 in this membrane.
