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In Focus

Postsynaptic signaling protein helps organize both pre- and postsynapses.

People & Ideas

Heuser uses quick-freeze, deep-etch electron microscopy to explore cellular ultrastructure.



Although Munc13-1 and Munc13-2 facilitate dense-core vesicle fusion, they are not required for DCV release, in contrast to their essential role in synaptic vesicle exocytosis.


In Special Collection: JCB65: DNA Replication and Repair

Variant repeats interspersed throughout ALT telomeres recruit nuclear receptors, leading to the destabilized telomere architecture and enhanced telomeric recombination.

An apolar patch and a polar cluster in the protein translocation channel cooperate to discriminate between signal sequences and less hydrophobic segments of cytosolic proteins.

Polypeptide translocation in bacteria, once underway, requires only one copy each of SecA and SecYEG and does not require the mobility of the SecA 2-helix-finger.

Mice expressing a version of Bub1 that lacks kinase activity have increased chromosome segregation errors and aneuploidy but not increased susceptibility to tumors.

The kinesin KIF14 associates with the PDZ domain of Radil and negatively regulates Rap1-mediated inside-out integrin activation by tethering Radil on microtubules.

Local cycling of LOK/SLK-dependent phosphorylation of ezrin is required for its apical localization and for microvillus formation.

Postsynaptic Farp1 helps to assemble a synaptic protein complex that promotes F-actin assembly and spine formation, and modulates active zones.

PI4KIIIα is targeted to the plasma membrane via an evolutionarily conserved complex comprised of EFR3 and TTC7 to control PtdIns4P synthesis and the selective enrichment of PtdIns(4,5)P2 in this membrane.

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