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Cover Image
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On the cover
When the tumor suppressor Lkb1 is inhibited in explants of embryonic pancreas, epithelial structures that resemble precancerous lesions are formed even though cell polarity—indicated by actin (red) and the basolateral marker EpCAM (green)—remains intact. Lo et al. use chemical genetics and ex vivo cultures to identify distinct Lkb1-dependent pathways in tissue morphogenesis and cancer development.
Image © 2012 Lo et al.
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In This Issue
In Focus
Lkb1 takes different paths to morphogenesis
Study uses chemical genetics and embryonic explants to reveal kinase’s tissue-specific functions.
People & Ideas
Li-Huei Tsai: I well remember
Tsai studies how Cdk5 activity affects brain development, learning, and memory.
Review
Report
Nucleotide excision repair–initiating proteins bind to oxidative DNA lesions in vivo
In vivo imaging reveals that CSB and XPC promote the repair of oxidative DNA lesions independent of the canonical nucleotide excision repair process.
Apoptotic regulators promote cytokinetic midbody degradation in C. elegans
Independent of their role in apoptosis, cell engulfment proteins are essential for midbody internalization and degradation after cell division.
Cab45 is required for Ca2+-dependent secretory cargo sorting at the trans-Golgi network
The Golgi resident protein Cab45 is required for trans-Golgi network Ca2+ homeostasis and sorting of cargos that are destined for secretion.
Article
The chromatin remodeler p400 ATPase facilitates Rad51-mediated repair of DNA double-strand breaks
The chromatin remodeling enzyme p400 forms a complex with Rad51 and is required for its recruitment to double-strand breaks during DNA repair by homologous recombination.
Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis
Cep164 provides a molecular link between the mother centriole and the ciliary membrane biogenesis machinery by interacting with the GEF Rabin8 and the GTPase Rab8.
VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx
VEGF causes translocation of Syx from endothelial cell junctions, promoting junction disassembly, whereas Angtiopoietin-1 maintains Syx at the junctions and stabilizes them.
Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways
A combination of ex vivo embryonic tissue culture, genetic manipulation, and chemical genetics reveals novel details of Lkb1-mediated regulation of tissue morphogenesis.
Tao controls epithelial morphogenesis by promoting Fasciclin 2 endocytosis
Tao initiates morphogenesis of a squamous epithelium by promoting the endocytosis of the adhesion molecule Fasciclin 2 from the lateral membrane.
Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival
Plasma membrane calcium ATPases PMCA1 and PMCA4 regulate osteoclast differentiation and survival by regulating NFATc1 and NO.
