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Cover Image
Cover Image
On the cover
Primary myoblasts labeled with red and green fluorescent membrane probes fuse to form double-labeled, multinucleated myotubes, a key step in the development of skeletal muscle. Leikina et al. reveal that phospholipid-binding annexin proteins and the GTPase dynamin regulate sequential steps of myoblast fusion.
Image courtesy of Evgenia Leikina.
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In This Issue
In Focus
The two stages of cell fusion
Cells switch molecular lineups for initial and later phases of fusion.
People & Ideas
Gillian Griffiths: How T cells get on target
Griffiths studies how cytotoxic T cells deliver their lethal payloads.
Review
Report
Molecular requirements for the formation of a kinetochore–microtubule interface by Dam1 and Ndc80 complexes
Correct kinetochore–microtubule attachments in budding yeast rely on the conserved CH-domain function of the kinetochore component Ndc80 and its ability to cooperate with the spindle-associated Dam1 complex.
Article
ATAD5 regulates the lifespan of DNA replication factories by modulating PCNA level on the chromatin
Reduction of ATAD5 extends the lifespan of replication factories by retaining PCNA and other replisome proteins on chromatin, leading to an increase in inactive replication factories and reduced overall replication rate.
The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly
Engineered kinetochores reveal distinct functions of the CCAN in recruiting CENP-A to the centromere and acting as a structural core to directly recruit kinetochore proteins.
Neurobeachin regulates neurotransmitter receptor trafficking to synapses
Neurobeachin regulates synaptic transmission by targeting neurotransmitter receptors to synapses under basal conditions.
Cdc42 interacts with the exocyst complex to promote phagocytosis
Interaction of Cdc42 with the exocyst complex selectively promotes the internalization of large particles.
Compression and dilation of the membrane-cortex layer generates rapid changes in cell shape
A cyclic process of membrane-cortex compression and dilation generates a traveling wave of cortical actin density that in turn generates oscillations in cell morphology.
Extracellular annexins and dynamin are important for sequential steps in myoblast fusion
Annexins A1 and A5 are important for initial lipid mixing, whereas subsequent stages of myoblast fusion depend on dynamin, phosphatidylinositol(4,5)bisphosphate, and cellular metabolism.
