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    Primary myoblasts labeled with red and green fluorescent membrane probes fuse to form double-labeled, multinucleated myotubes, a key step in the development of skeletal muscle. Leikina et al. reveal that phospholipid-binding annexin proteins and the GTPase dynamin regulate sequential steps of myoblast fusion.
    Image courtesy of Evgenia Leikina.
    See page 109.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Cells switch molecular lineups for initial and later phases of fusion.

People & Ideas

Griffiths studies how cytotoxic T cells deliver their lethal payloads.

Review

Report

Correct kinetochore–microtubule attachments in budding yeast rely on the conserved CH-domain function of the kinetochore component Ndc80 and its ability to cooperate with the spindle-associated Dam1 complex.

Article

Reduction of ATAD5 extends the lifespan of replication factories by retaining PCNA and other replisome proteins on chromatin, leading to an increase in inactive replication factories and reduced overall replication rate.

Engineered kinetochores reveal distinct functions of the CCAN in recruiting CENP-A to the centromere and acting as a structural core to directly recruit kinetochore proteins.

Neurobeachin regulates synaptic transmission by targeting neurotransmitter receptors to synapses under basal conditions.

Interaction of Cdc42 with the exocyst complex selectively promotes the internalization of large particles.

A cyclic process of membrane-cortex compression and dilation generates a traveling wave of cortical actin density that in turn generates oscillations in cell morphology.

Annexins A1 and A5 are important for initial lipid mixing, whereas subsequent stages of myoblast fusion depend on dynamin, phosphatidylinositol(4,5)bisphosphate, and cellular metabolism.

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