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People & Ideas
Enzymatic activity of the UvrD DNA helicase FBH1 is required for the efficient induction of DSBs and apoptosis specifically in response to DNA replication stress.
Chromosomal gain promotes formation of a steep RanGTP gradient that drives mitosis in aneuploid cells
The chromosome-centered RanGTP gradient, which is strongly reduced in slow-growing normal cells, is amplified by chromosomal gain and is required for mitosis in rapidly growing aneuploid cells.
PINK1 activates the HECT-like E3 ubiquitin ligase activity and self-association of Parkin upstream of its translocation to mitochondria and induction of mitophagy.
Ligase IV, but not its catalytic function, is required for DNA-PK–dependent end synapsis during nonhomologous end joining.
Cathepsin L degrades 53BP1 to overcome genomic instability and growth arrest in BRCA1-deficient and triple-negative breast cancers.
Polar ejection forces, which push chromosomes away from spindle poles, modulate kinetochore–microtubule attachment stability.
Perlecan/Trol at the neuromuscular junction suppresses presynaptic canonical Wg signaling but enhances the postsynaptic Frizzled nuclear import pathway.