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Cover Image
Cover Image
On the cover
Cane et al. reveal that overexpression of the chromokinesin motor NOD (red) stabilizes aberrant interactions between kinetochores and spindle microtubules (green), resulting in the incorrect attachment of sister chromatids to microtubules emanating from the same spindle pole.
Image courtesy of Tom Maresca.
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In This Issue
In Focus
How to live without BRCA1
Enzyme helps cancer cells reactivate repair mechanism and overcome loss of tumor suppressor.
People & Ideas
Samara Reck-Peterson: Dynein defies expectations
Reck-Peterson studies the mechanism and regulation of dynein’s motor activity.
Review
Report
FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress
Enzymatic activity of the UvrD DNA helicase FBH1 is required for the efficient induction of DSBs and apoptosis specifically in response to DNA replication stress.
Chromosomal gain promotes formation of a steep RanGTP gradient that drives mitosis in aneuploid cells
The chromosome-centered RanGTP gradient, which is strongly reduced in slow-growing normal cells, is amplified by chromosomal gain and is required for mitosis in rapidly growing aneuploid cells.
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding
PINK1 activates the HECT-like E3 ubiquitin ligase activity and self-association of Parkin upstream of its translocation to mitochondria and induction of mitophagy.
Article
A noncatalytic function of the ligation complex during nonhomologous end joining
Ligase IV, but not its catalytic function, is required for DNA-PK–dependent end synapsis during nonhomologous end joining.
BRCA1 loss activates cathepsin L–mediated degradation of 53BP1 in breast cancer cells
Cathepsin L degrades 53BP1 to overcome genomic instability and growth arrest in BRCA1-deficient and triple-negative breast cancers.
Elevated polar ejection forces stabilize kinetochore–microtubule attachments
Polar ejection forces, which push chromosomes away from spindle poles, modulate kinetochore–microtubule attachment stability.
Perlecan regulates bidirectional Wnt signaling at the Drosophila neuromuscular junction
Perlecan/Trol at the neuromuscular junction suppresses presynaptic canonical Wg signaling but enhances the postsynaptic Frizzled nuclear import pathway.
