On the cover
Pettem et al. reveal that the neuronal protein MDGA1 suppresses the development of inhibitory synapses by disrupting the interaction between neuroligin-2 and neurexin-1, two synaptic cell adhesion molecules associated with autism and schizophrenia. Cultured hippocampal neurons overexpressing MDGA1 (green) show a reduced density of inhibitory inputs (labeled with vesicular GABA transporter, red) compared with neighboring, untransfected neurons. The dendritic marker MAP2 is labeled blue.
Image © 2013 Pettem et al.
See page 321.
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