On the cover
Ono et al. demonstrate that condensin II induces the resolution of sister chromatids during S phase. The condensin II subunit CAP-H2 (magenta) forms “sister axes” along regions of prematurely condensed, S-phase chromosomes (blue) that have already replicated but is not localized to regions undergoing active DNA synthesis (marked by the incorporation of EdU, green).
Image courtesy of Takao Ono.
See page 429.
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
In This Issue
People & Ideas
Telomere-localized SUN and KASH proteins induce formation of a microtubule-based “telocentrosome” that fosters microtubule motor-dependent telomere clustering.
SecYEG drives conformational changes in the cotranslational targeting complex to activate it for GTP hydrolysis and the handover of the translating ribosome.
Cell polarity can be established via the spatial coordination of the opposing membrane trafficking activities of endocytosis and exocytosis.
Condensin II initiates structural reorganization of duplicated chromosomes during S phase to prepare for their proper condensation and segregation in mitosis.
Rbfox3 is required to promote neuronal differentiation of postmitotic neurons through Numb alternative splicing.
A comprehensive, cross-species electron tomography analysis of kinetochore–microtubule interfaces has provided insight into shared structural features and their likely functional consequences.
Active Rag GTPases are required for recruitment of TFEB to lysosomes and its phosphorylation by mTORC1, inhibiting its function under nutrient-rich conditions.
Grb2 inhibits the kinase activity of FGFR2 and the phosphatase activity of Shp2 to maintain homeostasis of receptor phosphorylation in the nonstimulated state.
The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis
A functional screen identified MARK4 as a positive regulator of axonemal extension and ciliogenesis via its interaction with the mother centriolar protein ODF2.
Obscurin contributes to the organization of subsarcolemma microtubules, localization of dystrophin at costameres, and maintenance of sarcolemmal integrity in skeletal muscle fibers.
Canonical Wnt signaling through Fzd8 and β-catenin negatively regulates osteoclast differentiation and reduces bone resorption independent of osteoprotegerin.