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    Ono et al. demonstrate that condensin II induces the resolution of sister chromatids during S phase. The condensin II subunit CAP-H2 (magenta) forms “sister axes” along regions of prematurely condensed, S-phase chromosomes (blue) that have already replicated but is not localized to regions undergoing active DNA synthesis (marked by the incorporation of EdU, green).
    Image courtesy of Takao Ono.
    See page 429.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Researchers find that endocytosis confines exocytosis to narrow zone during cell polarization.

People & Ideas

Doxsey studies how centrosomes and pericentriolar material affect cell function.



Telomere-localized SUN and KASH proteins induce formation of a microtubule-based “telocentrosome” that fosters microtubule motor-dependent telomere clustering.

SecYEG drives conformational changes in the cotranslational targeting complex to activate it for GTP hydrolysis and the handover of the translating ribosome.

Cell polarity can be established via the spatial coordination of the opposing membrane trafficking activities of endocytosis and exocytosis.

PtdIns(4,5)P2 promotes the assembly of LRP6 signalosomes at the cell surface via the recruitment of AP2 and clathrin.


Condensin II initiates structural reorganization of duplicated chromosomes during S phase to prepare for their proper condensation and segregation in mitosis.

Rbfox3 is required to promote neuronal differentiation of postmitotic neurons through Numb alternative splicing.

A comprehensive, cross-species electron tomography analysis of kinetochore–microtubule interfaces has provided insight into shared structural features and their likely functional consequences.

Active Rag GTPases are required for recruitment of TFEB to lysosomes and its phosphorylation by mTORC1, inhibiting its function under nutrient-rich conditions.

Grb2 inhibits the kinase activity of FGFR2 and the phosphatase activity of Shp2 to maintain homeostasis of receptor phosphorylation in the nonstimulated state.

A functional screen identified MARK4 as a positive regulator of axonemal extension and ciliogenesis via its interaction with the mother centriolar protein ODF2.

Obscurin contributes to the organization of subsarcolemma microtubules, localization of dystrophin at costameres, and maintenance of sarcolemmal integrity in skeletal muscle fibers.

Canonical Wnt signaling through Fzd8 and β-catenin negatively regulates osteoclast differentiation and reduces bone resorption independent of osteoprotegerin.

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