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JCB65: DNA Replication and Repair

In the eighth collection celebrating our 65th anniversary, we revisit studies of how features of chromosome structure are linked to nuclear function through the study of DNA replication and its organization, work detailing the pre-replication and replication complexes, their assembly during the cell cycle, and their relationship to replication forks and replication timing. Important studies of DNA damage responses and DNA repair are included, providing fundamental insight into the machinery underlying repair, such as the study identifying γ-H2AX foci as an evolutionarily conserved response to double-stranded DNA breaks. We explore more recent work shedding light into the mechanisms maintaining genome stability, including during replication stress, with studies implicating reversed forks as important intermediates for replication-associated processing events. If we missed your favorite JCB study, tweet to @JCellBiol using the hashtag #JCB65, or email us at [email protected]. Find more 65th anniversary collections or browse our From the Archive series.

Image from Lima-de-Faria, 1959.

Special Collection Image
Yuntao Xia; Irena L. Ivanovska; Kuangzheng Zhu; Lucas Smith; Jerome Irianto; Charlotte R. Pfeifer; Cory M. Alvey; Jiazheng Ji; Dazhen Liu; Sangkyun Cho; Rachel R. Bennett; Andrea J. Liu; Roger A. Greenberg; Dennis E. Discher
Wanqing Xiang; M. Julia Roberti; Jean-Karim Hériché; Sébastien Huet; Stephanie Alexander; Jan Ellenberg
Emily J. Platt; Leslie Smith; Mathew J. Thayer
Bramwell G. Lambrus; Yumi Uetake; Kevin M. Clutario; Vikas Daggubati; Michael Snyder; Greenfield Sluder; Andrew J. Holland
Saravanabhavan Thangavel; Matteo Berti; Maryna Levikova; Cosimo Pinto; Shivasankari Gomathinayagam; Marko Vujanovic; Ralph Zellweger; Hayley Moore; Eu Han Lee; Eric A. Hendrickson; Petr Cejka; Sheila Stewart; Massimo Lopes; Alessandro Vindigni
Ralph Zellweger; Damian Dalcher; Karun Mutreja; Matteo Berti; Jonas A. Schmid; Raquel Herrador; Alessandro Vindigni; Massimo Lopes
Kai J. Neelsen; Isabella M.Y. Zanini; Raquel Herrador; Massimo Lopes
Dimitri Conomos; Michael D. Stutz; Mark Hills; Axel A. Neumann; Tracy M. Bryan; Roger R. Reddel; Hilda A. Pickett
Simon Bekker-Jensen; Claudia Lukas; Risa Kitagawa; Fredrik Melander; Michael B. Kastan; Jiri Bartek; Jiri Lukas
Irene M. Ward; Bernardo Reina-San-Martin; Alexandru Olaru; Kay Minn; Koji Tamada; Julie S. Lau; Marilia Cascalho; Lieping Chen; Andre Nussenzweig; Ferenc Livak; Michel C. Nussenzweig; Junjie Chen
Irene Rappold; Kuniyoshi Iwabuchi; Takayasu Date; Junjie Chen
Emmy P. Rogakou; Chye Boon; Christophe Redon; William M. Bonner
Daniela S. Dimitrova; Ivan T. Todorov; Thomas Melendy; David M. Gilbert
Dean A. Jackson; Ana Pombo
R T O'Keefe; S C Henderson; D L Spector
R Bravo; H Macdonald-Bravo
A. Lima-de-Faria
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