JCB65: DNA Replication and Repair

In the eighth collection celebrating our 65th anniversary, we revisit studies of how features of chromosome structure are linked to nuclear function through the study of DNA replication and its organization, work detailing the pre-replication and replication complexes, their assembly during the cell cycle, and their relationship to replication forks and replication timing. Important studies of DNA damage responses and DNA repair are included, providing fundamental insight into the machinery underlying repair, such as the study identifying γ-H2AX foci as an evolutionarily conserved response to double-stranded DNA breaks. We explore more recent work shedding light into the mechanisms maintaining genome stability, including during replication stress, with studies implicating reversed forks as important intermediates for replication-associated processing events. If we missed your favorite JCB study, tweet to @JCellBiol using the hashtag #JCB65, or email us at [email protected]. Find more 65th anniversary collections or browse our From the Archive series.

Image from Lima-de-Faria, 1959.