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JCB65: DNA Replication and Repair

In the eighth collection celebrating our 65th anniversary, we revisit studies of how features of chromosome structure are linked to nuclear function through the study of DNA replication and its organization, work detailing the pre-replication and replication complexes, their assembly during the cell cycle, and their relationship to replication forks and replication timing. Important studies of DNA damage responses and DNA repair are included, providing fundamental insight into the machinery underlying repair, such as the study identifying γ-H2AX foci as an evolutionarily conserved response to double-stranded DNA breaks. We explore more recent work shedding light into the mechanisms maintaining genome stability, including during replication stress, with studies implicating reversed forks as important intermediates for replication-associated processing events. If we missed your favorite JCB study, tweet to @JCellBiol using the hashtag #JCB65, or email us at jcellbiol@rockefeller.edu. Find more 65th anniversary collections or browse our From the Archive series.

Image from Lima-de-Faria, 1959.

Special Collection Image
Yuntao Xia; Irena L. Ivanovska; Kuangzheng Zhu; Lucas Smith; Jerome Irianto; Charlotte R. Pfeifer; Cory M. Alvey; Jiazheng Ji; Dazhen Liu; Sangkyun Cho; Rachel R. Bennett; Andrea J. Liu; Roger A. Greenberg; Dennis E. Discher
10.1083/jcb.201711161
Wanqing Xiang; M. Julia Roberti; Jean-Karim Hériché; Sébastien Huet; Stephanie Alexander; Jan Ellenberg
10.1083/jcb.201709074
Emily J. Platt; Leslie Smith; Mathew J. Thayer
10.1083/jcb.201707082
Bramwell G. Lambrus; Yumi Uetake; Kevin M. Clutario; Vikas Daggubati; Michael Snyder; Greenfield Sluder; Andrew J. Holland
10.1083/jcb.201502089
Saravanabhavan Thangavel; Matteo Berti; Maryna Levikova; Cosimo Pinto; Shivasankari Gomathinayagam; Marko Vujanovic; Ralph Zellweger; Hayley Moore; Eu Han Lee; Eric A. Hendrickson; Petr Cejka; Sheila Stewart; Massimo Lopes; Alessandro Vindigni
10.1083/jcb.201406100
Ralph Zellweger; Damian Dalcher; Karun Mutreja; Matteo Berti; Jonas A. Schmid; Raquel Herrador; Alessandro Vindigni; Massimo Lopes
10.1083/jcb.201406099
Kai J. Neelsen; Isabella M.Y. Zanini; Raquel Herrador; Massimo Lopes
10.1083/jcb.201212058
Dimitri Conomos; Michael D. Stutz; Mark Hills; Axel A. Neumann; Tracy M. Bryan; Roger R. Reddel; Hilda A. Pickett
10.1083/jcb.201207189
Simon Bekker-Jensen; Claudia Lukas; Risa Kitagawa; Fredrik Melander; Michael B. Kastan; Jiri Bartek; Jiri Lukas
10.1083/jcb.200510130
Irene M. Ward; Bernardo Reina-San-Martin; Alexandru Olaru; Kay Minn; Koji Tamada; Julie S. Lau; Marilia Cascalho; Lieping Chen; Andre Nussenzweig; Ferenc Livak; Michel C. Nussenzweig; Junjie Chen
10.1083/jcb.200403021
Irene Rappold; Kuniyoshi Iwabuchi; Takayasu Date; Junjie Chen
10.1083/jcb.153.3.613
Emmy P. Rogakou; Chye Boon; Christophe Redon; William M. Bonner
10.1083/jcb.146.5.905
Daniela S. Dimitrova; Ivan T. Todorov; Thomas Melendy; David M. Gilbert
10.1083/jcb.146.4.709
Dean A. Jackson; Ana Pombo
10.1083/jcb.140.6.1285
R T O'Keefe; S C Henderson; D L Spector
10.1083/jcb.116.5.1095
R Bravo; H Macdonald-Bravo
10.1083/jcb.105.4.1549
A. Lima-de-Faria
10.1083/jcb.6.3.457
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