-
Cover Image
Cover Image
On the cover
A 3D visualization shows the photoreceptor projections in an adult Drosophila brain. Haberman et al. reveal that, in addition to regulating synaptic vesicle exocytosis, the SNARE protein Synaptobrevin also promotes endolysosomal degradation. Loss of this degradation mechanism in photoreceptors leads to adult-onset neurodegeneration.
Image courtesy of Robin Hiesinger.
See page 261. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
In This Issue
In Focus
Spare the Rod1, spoil transporter endocytosis
Study reveals how yeast shuffle transporter molecules in response to glucose.
People & Ideas
Tobias Walther: Floating ideas on lipids
Walther studies how cells use and store lipids to maintain membrane composition.
Review
Report
Novel plant SUN–KASH bridges are involved in RanGAP anchoring and nuclear shape determination
SUN–KASH nuclear envelope bridges formed by WIP and SUN proteins are present in the plant branch of the tree of life but have functionally diverged from their opisthokont counterparts and are involved in nuclear morphology and RanGAP–nuclear envelope association.
Quantitative analysis of the lipidomes of the influenza virus envelope and MDCK cell apical membrane
Analysis of the lipid composition of influenza virus–infected cells provides support for the membrane raft-based biogenesis model.
FAK promotes recruitment of talin to nascent adhesions to control cell motility
An alternative linkage is shown whereby FAK brings talin to nascent adhesions independent of talin binding to β1 integrins.
Article
The dynamics of replication licensing in live Caenorhabditis elegans embryos
Live imaging in Caenorhabditis elegans provides an unprecedented view of the chromatin-binding behavior and subcellular localization of origin replication licensing proteins during early embryogenesis.
A molecular switch on an arrestin-like protein relays glucose signaling to transporter endocytosis
Glucose remodels the post-translational modifications of the yeast arrestin-like protein Rod1 to promote glucose-induced transporter endocytosis.
The synaptic vesicle SNARE neuronal Synaptobrevin promotes endolysosomal degradation and prevents neurodegeneration
The synaptic v-SNARE n-Syb functions not only in synaptic vesicle exocytosis but also in delivery of protein-degrading enzymes to endosomes that are necessary to prevent protein aggregation and neurodegeneration.
Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration
Phosphatidic acid generation by DGK-α is essential for the localization of Rab11-coupling protein to invasive pseudopods and subsequent invasive migration by tumor cells.
