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Cover Image
Cover Image
On the cover
Oakes et al. demonstrate that radial actin stress fibers (identified by their orientation and pseudocolored blue), which associate with focal adhesions (red), are not required to transmit force from the actin cytoskeleton (gray) but are crucial for focal adhesion maturation.
Image courtesy of Yvonne Beckham and Patrick Oakes.
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In This Issue
In Focus
Stress fibers guide focal adhesions to maturity
Study suggests that actin bundles serve as templates for adhesion growth.
People & Ideas
Pamela Silver: Synthesizing a new biology
Silver's lab uses systems biology to inform the design of novel synthetic functions in cells.
Review
Report
Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export
Altering pyrimidine levels in influenza virus– or VSV-infected cells reverses the inhibitory effect of viral proteins NS1 and M on host mRNA nuclear export, restoring expression of host antiviral factors.
The small G protein Arl1 directs the trans-Golgi–specific targeting of the Arf1 exchange factors BIG1 and BIG2
Specificity in Arf1 GEF recruitment to the trans-Golgi, and thus in localized Arf1 activation, is provided by an Arf-like G protein.
The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves
Deletion of the Schwann cell cytoskeletal adapter protein 4.1G led to aberrant distribution of glial adhesion molecules and axonal proteins along the internodes.
Article
FoxO limits microtubule stability and is itself negatively regulated by microtubule disruption
FoxO inhibits microtubule stability in the central nervous system, making its degradation an essential component of a cell’s protective response to cytoskeletal insult.
Tension is required but not sufficient for focal adhesion maturation without a stress fiber template
Lamellar actin architecture at adhesion sites may serve as a structural template that facilitates focal adhesion maturation over a wide range of tension.
Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK–p130Cas complex
Targeting of the MT1-MMP protease to focal adhesions by focal adhesion kinase and p130Cas is required for efficient extracellular matrix degradation and tumor cell invasion.
