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Issues

ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Study suggests that actin bundles serve as templates for adhesion growth.

People & Ideas

Silver's lab uses systems biology to inform the design of novel synthetic functions in cells.

Review

Report

Altering pyrimidine levels in influenza virus– or VSV-infected cells reverses the inhibitory effect of viral proteins NS1 and M on host mRNA nuclear export, restoring expression of host antiviral factors.

Specificity in Arf1 GEF recruitment to the trans-Golgi, and thus in localized Arf1 activation, is provided by an Arf-like G protein.

Deletion of the Schwann cell cytoskeletal adapter protein 4.1G led to aberrant distribution of glial adhesion molecules and axonal proteins along the internodes.

Article

FoxO inhibits microtubule stability in the central nervous system, making its degradation an essential component of a cell’s protective response to cytoskeletal insult.

Lamellar actin architecture at adhesion sites may serve as a structural template that facilitates focal adhesion maturation over a wide range of tension.

Targeting of the MT1-MMP protease to focal adhesions by focal adhesion kinase and p130Cas is required for efficient extracellular matrix degradation and tumor cell invasion.

Correction

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