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Cover Image
Cover Image
On the cover
Wynne et al. visualize meiotic chromosome dynamics in live C. elegans animals. A time-lapse series (top) shows that movements of the X chromosomes (magenta) are mostly led by the pairing centers (green)—specialized chromosome regions that drive homologue pairing in early meiosis. Mapping the trajectories of multiple pairing centers on a representative nucleus (bottom) illustrates how their motions cover the nuclear envelope to help chromosomes find their homologous partner.
Image courtesy of David Wynne and Ofer Rog.
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In This Issue
In Focus
Building up actin at adherens junctions
A biochemical approach reveals that α-actinin-4 and Arp2/3 team up to assemble actin at intercellular adhesions.
People & Ideas
Keith Burridge: Cultivating knowledge on Rho
Burridge studies how Rho proteins regulate everything from focal adhesions to leukocyte migration.
Review
Report
Ubiquitylation of the nuclear pore complex controls nuclear migration during mitosis in S. cerevisiae
A systematic analysis revealed that the nuclear pore complex is extensively modified by ubiquitin and that ubiquitylation of the NPC component Nup159 is required for dynein light chain targeting to the NPC and proper nuclear segregation during mitosis.
Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia
PTEN nuclear entry driven by ubiquitination is mediated by the ligase-interacting protein Ndfip1 and is essential for neuronal survival in mice after cerebral ischemia.
The vesicular SNARE Synaptobrevin is required for Semaphorin 3A axonal repulsion
Semaphorin 3A-mediated signaling and axonal repulsion in the mouse brain require Synaptobrevin-dependent vesicular traffic.
Article
Dynein-dependent processive chromosome motions promote homologous pairing in C. elegans meiosis
High-resolution time-lapse imaging of meiosis in C. elegans reveals stage-specific, dynein-driven chromosome motion that accelerates homologue pairing and triggers synapsis.
dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions
Drosophila EHBP1 is a novel regulator of Notch signaling that may function as an adaptor protein during the exocytosis and recycling of the Notch ligand Delta.
RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway
RAB-6.2, its effector LIN-10, and the retromer complex maintain synaptic strength by recycling postsynaptic glutamate receptors along the retrograde transport pathway.
The septin cytoskeleton facilitates membrane retraction during motility and blebbing
Septins assemble on the cortex and restore normal cell shape by retracting aberrantly protruding membranes and promoting cortical contraction during amoeboid motility.
α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction
α-Actinin-4 plays an important role in coupling actin nucleation to assembly at cadherin-based cell–cell adhesive contacts.
Structural specializations of α4β7, an integrin that mediates rolling adhesion
Electron microscopy and crystallography studies of α4β7 integrin reveal the mechanism by which this atypical integrin enables rolling adhesion prior to integrin activation.
A novel function for Cyclin A2: Control of cell invasion via RhoA signaling
Cyclin A2 promotes RhoA activation, which inhibits cytoskeletal rearrangements and cell migration.
PAI-1–regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy
Extracellular proteolysis mediated by the uPA/PAI-1 system determines miR-21 expression in fibroblasts, which affects age-associated fibrogenesis and muscle deterioration in a muscular dystrophy model.
