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Journal Articles

Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions

Sofia F. Nazarova, Vadim A. Alekhin, Vladislav V. Pavlov, Yury S. Semenov, Siarhei M. Bukhalovich, Fedor M. Tsybrov, Andrey O. Bogorodskiy, Diana F. Bagaeva, Olga V. Moiseeva, Anastasiia D. Vlasova, Anatolii E. Mikhailov, Yayu Wang, Andrey V. Rogachev, Semen V. Nesterov, Valentin I. Borshchevskiy, Chunlei Cang, Piotr D. Bregestovski, Valentin I. Gordeliy, Nikolay S. Ilyinsky
Journal: Journal of General Physiology
Series: Molecular evolution in the membrane
J Gen Physiol (2026) 158 (4): e202413745.
https://doi.org/10.1085/jgp.202413745
Published: 18 June 2026
View article titled, Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions
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Includes: Supplementary data
Journal Articles

Opening of rod photoreceptor CNG channels by photodynamically generated singlet oxygen

Gaogao He, Xiaoxi Li, Yanlin Huang, Conghan Wang, Minjie Tan, Qinglian Liu, Lei Zhou
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202513819.
https://doi.org/10.1085/jgp.202513819
Published: 05 March 2026
View article titled, Opening of rod photoreceptor CNG channels by photodynamically generated singlet oxygen
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Journal Articles

ERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells

In Special Collection:
Neuroscience Collection 2025
Evelyn C. Avilés, Sean K. Wang, Sarina Patel, Sebastian Cordero, Shuxiang Shi, Lucas Lin, Vladimir J. Kefalov, Lisa V. Goodrich, Constance L. Cepko, Yunlu Xue
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (2): e202413642.
https://doi.org/10.1085/jgp.202413642
Published: 04 February 2025
View article titled, ERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells
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Includes: Supplementary data
Journal Articles

BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy

In Special Collection:
Neuroscience Collection 2023 , Molecular Insights into Membrane Protein Function
Yanyan Geng, Ping Li, Alice Butler, Bill Wang, Lawrence Salkoff, Karl L. Magleby
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (5): e202213302.
https://doi.org/10.1085/jgp.202213302
Published: 30 March 2023
View article titled, BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy
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Journal Articles

Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension

Yong-Xiao Wang, Jorge Reyes-García, Annarita Di Mise, Yun-Min Zheng
Journal: Journal of General Physiology
Series: Excitation–Contraction Coupling
J Gen Physiol (2023) 155 (3): e202213100.
https://doi.org/10.1085/jgp.202213100
Published: 10 January 2023
View article titled, Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension
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Journal Articles

Myosin essential light chain 1sa decelerates actin and thin filament gliding on β-myosin molecules

Jennifer Osten, Maral Mohebbi, Petra Uta, Faramarz Matinmehr, Tianbang Wang, Theresia Kraft, Mamta Amrute-Nayak, Tim Scholz
Journal: Journal of General Physiology
J Gen Physiol (2022) 154 (10): e202213149.
https://doi.org/10.1085/jgp.202213149
Published: 02 September 2022
View article titled, Myosin essential light chain 1sa decelerates actin and thin filament gliding on β-myosin molecules
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Includes: Supplementary data
Journal Articles

ORAI3 is dispensable for store-operated Ca2+ entry and immune responses by lymphocytes and macrophages

Liwei Wang, Lucile Noyer, Yin-Hu Wang, Anthony Y. Tao, Wenyi Li, Jingjie Zhu, Pedro Saavedra, Syed T. Hoda, Jun Yang, Stefan Feske
Journal: Journal of General Physiology
Series: Channels and Transporters in Immunity
J Gen Physiol (2022) 154 (10): e202213104.
https://doi.org/10.1085/jgp.202213104
Published: 21 July 2022
View article titled, ORAI3 is dispensable for store-operated Ca2+ entry and immune responses by lymphocytes and macrophages
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Includes: Supplementary data
Journal Articles

Catecholamines are key modulators of ventricular repolarization patterns in the ball python (Python regius)

Bastiaan J.D. Boukens, William Joyce, Ditte Lind Kristensen, Ingeborg Hooijkaas, Aldo Jongejan, Tobias Wang, Bjarke Jensen
Journal: Journal of General Physiology
J Gen Physiol (2021) 154 (2): e202012761.
https://doi.org/10.1085/jgp.202012761
Published: 15 December 2021
View article titled, Catecholamines are key modulators of ventricular repolarization patterns in the ball python (Python regius)
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Includes: Supplementary data
Journal Articles

A non-transmembrane channel formed by Ca2+-bound calsequestrin-2: Calcium Signaling and Excitation–Contraction in Cardiac, Skeletal and Smooth Muscle

Xue-Xin Fan, Zihao Liu, Hua Yu, Xinyi Huang, Chen Song, Xuefeng Guo, Shi-Qiang Wang
Journal: Journal of General Physiology
Series: E–C Coupling Meeting 2021
J Gen Physiol (2021) 154 (9): e2021ecc8.
https://doi.org/10.1085/jgp.2021ecc8
Published: 12 November 2021
View article titled, A non-transmembrane channel formed by Ca2+-bound calsequestrin-2: Calcium Signaling and Excitation–Contraction in Cardiac, Skeletal and Smooth Muscle
Journal Articles

ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state

Jodene Eldstrom, Donald A. McAfee, Ying Dou, Yundi Wang, David Fedida
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (12): e202112969.
https://doi.org/10.1085/jgp.202112969
Published: 12 October 2021
View article titled, ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state
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Journal Articles

Mechanical dysfunction of the sarcomere induced by a pathogenic mutation in troponin T drives cellular adaptation

Sarah R. Clippinger, Paige E. Cloonan, Wei Wang, Lina Greenberg, W. Tom Stump, Paweorn Angsutararux, Jeanne M. Nerbonne, Michael J. Greenberg
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (5): e202012787.
https://doi.org/10.1085/jgp.202012787
Published: 15 April 2021
View article titled, Mechanical dysfunction of the sarcomere induced by a pathogenic mutation in troponin T drives cellular adaptation
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Includes: Supplementary data
Journal Articles

DEG/ENaC/ASIC channels vary in their sensitivity to anti-hypertensive and non-steroidal anti-inflammatory drugs

In Special Collection:
Neuroscience Collection 2022
Sylvia Fechner, Isabel D’Alessandro, Lingxin Wang, Calvin Tower, Li Tao, Miriam B. Goodman
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (4): e202012655.
https://doi.org/10.1085/jgp.202012655
Published: 03 March 2021
View article titled, DEG/ENaC/ASIC channels vary in their sensitivity to anti-hypertensive and non-steroidal anti-inflammatory drugs
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Journal Articles

Filament evanescence of myosin II and smooth muscle function

Lu Wang, Pasquale Chitano, Chun Y. Seow
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (3): e202012781.
https://doi.org/10.1085/jgp.202012781
Published: 19 February 2021
View article titled, Filament evanescence of myosin II and smooth muscle function
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Journal Articles

Mechanisms of proton inhibition and sensitization of the cation channel TRPV3

In Special Collection:
Protons and Membrane Function
Haiyuan Wang, Pu Yang, Yungang Lu, Jin Wang, Jaepyo Jeon, Qiaochu Wang, Jin-Bin Tian, Bin Zang, Ye Yu, Michael X. Zhu
Journal: Journal of General Physiology
J Gen Physiol (2020) 153 (2): e202012663.
https://doi.org/10.1085/jgp.202012663
Published: 15 December 2020
View article titled, Mechanisms of proton inhibition and sensitization of the cation channel TRPV3
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Journal Articles

Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation

In Special Collection:
Cardiac Physiology 2021
Hannah A. Ledford, Seojin Park, Duncan Muir, Ryan L. Woltz, Lu Ren, Phuong T. Nguyen, Padmini Sirish, Wenying Wang, Choong-Ryoul Sihn, Alfred L. George, Jr., Björn C. Knollmann, Ebenezer N. Yamoah, Vladimir Yarov-Yarovoy, Xiao-Dong Zhang, Nipavan Chiamvimonvat
Journal: Journal of General Physiology
J Gen Physiol (2020) 152 (12): e202012667.
https://doi.org/10.1085/jgp.202012667
Published: 19 November 2020
View article titled, Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation
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Includes: Supplementary data
Journal Articles

Mechanism and potential sites of potassium interaction with glutamate transporters

Jiali Wang, Kaiqi Zhang, Puja Goyal, Christof Grewer
Journal: Journal of General Physiology
J Gen Physiol (2020) 152 (10): e202012577.
https://doi.org/10.1085/jgp.202012577
Published: 20 August 2020
View article titled, Mechanism and potential sites of potassium interaction with glutamate transporters
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Includes: Supplementary data
Journal Articles

Depressed neuromuscular transmission causes weakness in mice lacking BK potassium channels

Xueyong Wang, Steven R.A. Burke, Robert J. Talmadge, Andrew A. Voss, Mark M. Rich
Journal: Journal of General Physiology
J Gen Physiol (2020) 152 (5): e201912526.
https://doi.org/10.1085/jgp.201912526
Published: 03 April 2020
View article titled, Depressed neuromuscular transmission causes weakness in mice lacking BK potassium channels
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Journal Articles

Regulation of heart rate and the pacemaker current by phosphoinositide 3-kinase signaling

In Special Collection:
Electrical Signaling in the Nervous System and Heart , Ion channel modulation
Richard Z. Lin, Zhongju Lu, Evgeny P. Anyukhovsky, Ya-Ping Jiang, Hong Zhan Wang, Junyuan Gao, Michael R. Rosen, Lisa M. Ballou, Ira S. Cohen
Journal: Journal of General Physiology
J Gen Physiol (2019) 151 (8): 1051–1058.
https://doi.org/10.1085/jgp.201812293
Published: 19 June 2019
View article titled, Regulation of heart rate and the pacemaker current by phosphoinositide 3-kinase signaling
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Includes: Supplementary data
Journal Articles

Mitoflash biogenesis and its role in the autoregulation of mitochondrial proton electrochemical potential

Gaomin Feng, Beibei Liu, Jinghang Li, Tianlei Cheng, Zhanglong Huang, Xianhua Wang, Heping (Peace) Cheng
Journal: Journal of General Physiology
J Gen Physiol (2019) 151 (6): 727–737.
https://doi.org/10.1085/jgp.201812176
Published: 15 March 2019
View article titled, Mitoflash biogenesis and its role in the autoregulation of mitochondrial proton electrochemical potential
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Includes: Supplementary data
Journal Articles

Novel alanine serine cysteine transporter 2 (ASCT2) inhibitors based on sulfonamide and sulfonic acid ester scaffolds

Elias Ndaru, Rachel-Ann A. Garibsingh, YueYue Shi, Evan Wallace, Paul Zakrepine, Jiali Wang, Avner Schlessinger, Christof Grewer
Journal: Journal of General Physiology
J Gen Physiol (2019) 151 (3): 357–368.
https://doi.org/10.1085/jgp.201812276
Published: 04 February 2019
View article titled, Novel alanine serine cysteine transporter 2 (ASCT2) inhibitors based on sulfonamide and sulfonic acid ester scaffolds
Open the PDF for Novel alanine serine cysteine transporter 2 (ASCT2) inhibitors based on sulfonamide and sulfonic acid ester scaffolds in another window
Includes: Supplementary data

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