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BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy

In Special Collection:

Neuroscience Collection 2023 , Molecular Insights into Membrane Protein Function

Yanyan Geng, Ping Li, Alice Butler, Bill Wang, Lawrence Salkoff, Karl L. Magleby

J Gen Physiol (2023) 155 (5): e202213302.

https://doi.org/10.1085/jgp.202213302

Published: 30 March 2023

View article titled, BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy

Journal Articles

Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels

Guohui Zhang, Yanyan Geng, Yakang Jin, Jingyi Shi, Kelli McFarland, Karl L. Magleby, Lawrence Salkoff, Jianmin Cui

J Gen Physiol (2017) 149 (3): 373–387.

https://doi.org/10.1085/jgp.201611646

Published: 14 February 2017

View article titled, Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels

Journal Articles

Modal gating of endplate acetylcholine receptors: A proposed mechanism

Yanyan Geng, Karl L. Magleby

J Gen Physiol (2015) 146 (6): 435–439.

https://doi.org/10.1085/jgp.201511534

Published: 30 November 2015

View article titled, Modal gating of endplate acetylcholine receptors: A proposed mechanism

Journal Articles

Lack of negative slope in I-V plots for BK channels at positive potentials in the absence of intracellular blockers

Yanyan Geng, Xiaoyu Wang, Karl L. Magleby

J Gen Physiol (2013) 141 (4): 493–497.

https://doi.org/10.1085/jgp.201210955

Published: 25 March 2013

View article titled, Lack of negative slope in I-V plots for BK channels at positive potentials in the absence of intracellular blockers

Journal Articles

Mg²⁺ binding to open and closed states can activate BK channels provided that the voltage sensors are elevated

Ren-Shiang Chen, Yanyan Geng, Karl L. Magleby

J Gen Physiol (2011) 138 (6): 593–607.

https://doi.org/10.1085/jgp.201110707

Published: 28 November 2011

View article titled, Mg2+ binding to open and closed states can activate BK channels provided that the voltage sensors are elevated

Journal Articles

Low resistance, large dimension entrance to the inner cavity of BK channels determined by changing side-chain volume

Yanyan Geng, Xiaowei Niu, Karl L. Magleby

J Gen Physiol (2011) 137 (6): 533–548.

https://doi.org/10.1085/jgp.201110616

Published: 16 May 2011

View article titled, Low resistance, large dimension entrance to the inner cavity of BK channels determined by changing side-chain volume

Journal Articles

Voltage- and cold-dependent gating of single TRPM8 ion channels

José A. Fernández, Roman Skryma, Gabriel Bidaux, Karl L. Magleby, C. Norman Scholfield, J. Graham McGeown, Natalia Prevarskaya, Alexander V. Zholos

J Gen Physiol (2011) 137 (2): 173–195.

https://doi.org/10.1085/jgp.201010498

Published: 31 January 2011

View article titled, Voltage- and cold-dependent gating of single TRPM8 ion channels

Includes: Supplementary data

Journal Articles

Coupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca²⁺

Christopher Shelley, Xiaowei Niu, Yanyan Geng, Karl L. Magleby

J Gen Physiol (2010) 135 (5): 461–480.

https://doi.org/10.1085/jgp.200910331

Published: 26 April 2010

View article titled, Coupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca2+

Includes: Supplementary data

Journal Articles

Linking Exponential Components to Kinetic States in Markov Models for Single-Channel Gating

Christopher Shelley, Karl L. Magleby

J Gen Physiol (2008) 132 (2): 295–312.

https://doi.org/10.1085/jgp.200810008

Published: 14 July 2008

View article titled, Linking Exponential Components to Kinetic States in Markov Models for Single-Channel Gating

Journal Articles

Correction

Xiang Qian, Xiaowei Niu, Karl L. Magleby

J Gen Physiol (2006) 128 (5): 629.

https://doi.org/10.1085/jgp.200609486092706c

Published: 16 October 2006

View article titled, Correction

Journal Articles

Intra- and Intersubunit Cooperativity in Activation of BK Channels by Ca²⁺

Xiang Qian, Xiaowei Niu, Karl L. Magleby

J Gen Physiol (2006) 128 (4): 389–404.

https://doi.org/10.1085/jgp.200609486

Published: 25 September 2006

View article titled, Intra- and Intersubunit Cooperativity in Activation of BK Channels by Ca2+

Journal Articles

Ring of Negative Charge in BK Channels Facilitates Block by Intracellular Mg²⁺ and Polyamines through Electrostatics

Yaxia Zhang, Xiaowei Niu, Tinatin I. Brelidze, Karl L. Magleby

J Gen Physiol (2006) 128 (2): 185–202.

https://doi.org/10.1085/jgp.200609493

Published: 17 July 2006

View article titled, Ring of Negative Charge in BK Channels Facilitates Block by Intracellular Mg2+ and Polyamines through Electrostatics

Journal Articles

Probing the Geometry of the Inner Vestibule of BK Channels with Sugars

Tinatin I. Brelidze, Karl L. Magleby

J Gen Physiol (2005) 126 (2): 105–121.

https://doi.org/10.1085/jgp.200509286

Published: 25 July 2005

View article titled, Probing the Geometry of the Inner Vestibule of BK Channels with Sugars

Journal Articles

Protons Block BK Channels by Competitive Inhibition with K⁺ and Contribute to the Limits of Unitary Currents at High Voltages

Tinatin I. Brelidze, Karl L. Magleby

J Gen Physiol (2004) 123 (3): 305–319.

https://doi.org/10.1085/jgp.200308951

Published: 23 February 2004

View article titled, Protons Block BK Channels by Competitive Inhibition with K+ and Contribute to the Limits of Unitary Currents at High Voltages

Journal Articles

Gating Mechanism of BK (Slo1) Channels : So Near, Yet So Far

Karl L. Magleby

J Gen Physiol (2003) 121 (2): 81–96.

https://doi.org/10.1085/jgp.20028721

Published: 13 January 2003

View article titled, Gating Mechanism of BK (Slo1) Channels : So Near, Yet So Far

Journal Articles

Slo1 Tail Domains, but Not the Ca²⁺ Bowl, Are Required for the β1 Subunit to Increase the Apparent Ca²⁺ Sensitivity of BK Channels

Xiang Qian, Crina M. Nimigean, Xiaowei Niu, Brenda L. Moss, Karl L. Magleby

J Gen Physiol (2002) 120 (6): 829–843.

https://doi.org/10.1085/jgp.20028692

Published: 25 November 2002

View article titled, Slo1 Tail Domains, but Not the Ca2+ Bowl, Are Required for the β1 Subunit to Increase the Apparent Ca2+ Sensitivity of BK Channels

Journal Articles

Gating and Conductance Properties of Bk Channels Are Modulated by the S9–S10 Tail Domain of the α Subunit: A Study of Mslo1 and Mslo3 Wild-Type and Chimeric Channels

Brenda L. Moss, Karl L. Magleby

J Gen Physiol (2001) 118 (6): 711–734.

https://doi.org/10.1085/jgp.118.6.711

Published: 26 November 2001

View article titled, Gating and Conductance Properties of Bk Channels Are Modulated by the S9–S10 Tail Domain of the α Subunit: A Study of Mslo1 and Mslo3 Wild-Type and Chimeric Channels

Journal Articles

Kinetic Gating Mechanisms for Bk Channels : When Complexity Leads to Simplicity

Karl L. Magleby

J Gen Physiol (2001) 118 (5): 583–588.

https://doi.org/10.1085/jgp.118.5.583

Published: 02 November 2001

View article titled, Kinetic Gating Mechanisms for Bk Channels : When Complexity Leads to Simplicity

Journal Articles

Voltage and Ca²⁺ Activation of Single Large-Conductance Ca²⁺-Activated K⁺ Channels Described by a Two-Tiered Allosteric Gating Mechanism

Brad S. Rothberg, Karl L. Magleby

J Gen Physiol (2000) 116 (1): 75–100.

https://doi.org/10.1085/jgp.116.1.75

Published: 01 July 2000

View article titled, Voltage and Ca2+ Activation of Single Large-Conductance Ca2+-Activated K+ Channels Described by a Two-Tiered Allosteric Gating Mechanism

Journal Articles

Functional Coupling of the β₁ Subunit to the Large Conductance Ca²⁺-Activated K⁺ Channel in the Absence of Ca²⁺: Increased Ca²⁺ Sensitivity from a Ca²⁺-Independent Mechanism

Crina M. Nimigean, Karl L. Magleby

J Gen Physiol (2000) 115 (6): 719–736.

https://doi.org/10.1085/jgp.115.6.719

Published: 01 June 2000

View article titled, Functional Coupling of the β1 Subunit to the Large Conductance Ca2+-Activated K+ Channel in the Absence of Ca2+ : Increased Ca2+ Sensitivity from a Ca2+-Independent Mechanism

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BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy

Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels

Modal gating of endplate acetylcholine receptors: A proposed mechanism

Lack of negative slope in I-V plots for BK channels at positive potentials in the absence of intracellular blockers

Mg²⁺ binding to open and closed states can activate BK channels provided that the voltage sensors are elevated

Low resistance, large dimension entrance to the inner cavity of BK channels determined by changing side-chain volume

Voltage- and cold-dependent gating of single TRPM8 ion channels

Coupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca²⁺

Linking Exponential Components to Kinetic States in Markov Models for Single-Channel Gating

Correction

Intra- and Intersubunit Cooperativity in Activation of BK Channels by Ca²⁺

Ring of Negative Charge in BK Channels Facilitates Block by Intracellular Mg²⁺ and Polyamines through Electrostatics

Probing the Geometry of the Inner Vestibule of BK Channels with Sugars

Protons Block BK Channels by Competitive Inhibition with K⁺ and Contribute to the Limits of Unitary Currents at High Voltages

Gating Mechanism of BK (Slo1) Channels : So Near, Yet So Far

Slo1 Tail Domains, but Not the Ca²⁺ Bowl, Are Required for the β1 Subunit to Increase the Apparent Ca²⁺ Sensitivity of BK Channels

Gating and Conductance Properties of Bk Channels Are Modulated by the S9–S10 Tail Domain of the α Subunit: A Study of Mslo1 and Mslo3 Wild-Type and Chimeric Channels

Kinetic Gating Mechanisms for Bk Channels : When Complexity Leads to Simplicity

Voltage and Ca²⁺ Activation of Single Large-Conductance Ca²⁺-Activated K⁺ Channels Described by a Two-Tiered Allosteric Gating Mechanism

Functional Coupling of the β₁ Subunit to the Large Conductance Ca²⁺-Activated K⁺ Channel in the Absence of Ca²⁺: Increased Ca²⁺ Sensitivity from a Ca²⁺-Independent Mechanism

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