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Journal Articles

The transcription factor IRF8 drives tumor-specific exhaustion in CD8+ T cells

Marco Ongaro, Romane Thouenon, Isaac Crespo, Alexandre Dumez, Mélanie Charmoy, Eduardo Roman Camacho, Victoria J. Morel, Daniela Cropp, Emma Desponds, Giulio Zanette, Yi-Chuan Wang, Letizia Vergili, Laure Tillé, Inés Di Resta, Marine M. Leblond, Jésus Corria Osorio, Ping-Chih Ho, Werner Held, Grégory Verdeil
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (8): e20252115.
https://doi.org/10.1084/jem.20252115
Published: 22 June 2026
View article titled, The transcription factor IRF8 drives tumor-specific exhaustion in CD8+ T cells
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Includes: Supplementary data
Journal Articles

Leveraging cDC1 biology and function for enhanced immunotherapy

Ross W. Ward, Uddipan Kar, Sreekumar Balan, Nina Bhardwaj
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2026) 223 (7): e20241199.
https://doi.org/10.1084/jem.20241199
Published: 10 June 2026
View article titled, Leveraging cDC1 biology and function for enhanced immunotherapy
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Journal Articles

Cathepsin S regulates germinal center reactions and anti-tumor humoral responses

Marine Bruand, Divyanshu Srivastava, Aaron Petruzzella, Maxime Petit, Samantha Mahfoud, Natalya Katanayeva, Asli Kasapoglu, Camille Landragin, Daniele Tavernari, Eleni Balli, Giovanni Ciriello, Tatiana V. Petrova, Elisa Oricchio
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (7): e20252463.
https://doi.org/10.1084/jem.20252463
Published: 01 June 2026
View article titled, Cathepsin S regulates germinal center reactions and anti-tumor humoral responses
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Includes: Supplementary data
Journal Articles

Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity

Xiaonan Ma, Henan Guo, Yuting Jia, Na Yin, Min Peng
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (7): e20252687.
https://doi.org/10.1084/jem.20252687
Published: 26 May 2026
View article titled, Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity
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Includes: Supplementary data
Journal Articles

Decoding TCR specificity and T cell fate at the immunological synapse

Rundi Zhu, Yuqian Wang, Guideng Li
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (6): e20260625.
https://doi.org/10.1084/jem.20260625
Published: 21 May 2026
View article titled, Decoding TCR specificity and T cell fate at the immunological synapse
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Journal Articles

CSF1R-dependent CD169-positive macrophages locally constrain melanoma growth in the skin

Yuki Honda Keith, Emily Duchini, Xufeng Lin, Wunna Kyaw, Felix G.P. Weninger, Rama Dhenni, Aiden Josiah Telfser, Abigail K. Grootveld, Deborah Barkauskas, Angela Fontaine-Titley, Shweta Tikoo, Rohit Jain, Wolfgang Weninger, John W. Frew, Elissa K. Deenick, Robert Brink, Linda K. Martin, Tatyana Chtanova, Leonard D. Goldstein, Richard A. Scolyer, Georgina V. Long, Umaimainthan Palendira, Tri Giang Phan
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (7): e20252239.
https://doi.org/10.1084/jem.20252239
Published: 21 May 2026
View article titled, CSF1R-dependent CD169-positive macrophages locally constrain melanoma growth in the skin
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Journal Articles

Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2–deficient environments

In Special Collection:
JEM Cancer Collection 2026
Rafael Blanco-Domínguez, André Miguel Vaz-Pinto, Leandro Barros, Noella Lopes, Beatriz Henriques-Alves, Mariana Carreira, Carlos Labão-Almeida, Julie C. Ribot, Gonçalo J.L. Bernardes, Bruno Silva-Santos, Sofia Mensurado
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (7): e20252133.
https://doi.org/10.1084/jem.20252133
Published: 13 May 2026
View article titled, Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2–deficient environments
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Journal Articles

PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity

Shibo Liu, Guanghao Liang, Yayun Yang, Yanyang Shi, Lihui Dong, Yue Zhao, Boyuan Mei, Jun Wang, Feng Lin, Yilin Li, Wenxin Dong, Chengyang Liu, Yuhui Cao, Dali Han, Peng R. Chen, Meng Michelle Xu
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (6): e20251779.
https://doi.org/10.1084/jem.20251779
Published: 12 May 2026
View article titled, PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity
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Includes: Supplementary data
Journal Articles

When tumor contact reshapes CAR-T cells

Sangwoo Park, Marcela V. Maus
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (6): e20260645.
https://doi.org/10.1084/jem.20260645
Published: 07 May 2026
View article titled, When tumor contact reshapes CAR-T cells
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Journal Articles

Rab5 improves CAR T cell efficacy via reducing fratricide and maintaining surface CAR levels

In Special Collection:
JEM Clinical Immunology Collection 2026
Meidi Gu, Kaitlin A. Read, Vipin Bhardwaj, Edmund J. Carvalho, David Nardo, Justin C. Shayne, Divanshu Shukla, Wei Liu, Donald L. Siegel, Neil C. Sheppard, Michael C. Milone, Adam D. Cohen, Alfred L. Garfall, James L. Riley
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (6): e20252564.
https://doi.org/10.1084/jem.20252564
Published: 05 May 2026
View article titled, Rab5 improves CAR T cell efficacy via reducing fratricide and maintaining surface CAR levels
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Includes: Supplementary data
Journal Articles

Testing the mettle of RNA methylation in T cell exhaustion

Cansu Yerinde, Debattama Rai Sen
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (5): e20260349.
https://doi.org/10.1084/jem.20260349
Published: 27 April 2026
View article titled, Testing the mettle of RNA methylation in T cell exhaustion
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Journal Articles

Targeting conserved domains of hypoxia-inducible factors for cancer therapy

Shaima Salman, Tina Y. Huang, Yousang Hwang, Anmol Kumar, Emmanuel Datan, Elizabeth E. Wicks, Ellen Cho, Sophia N. Lee, Chelsey Chen, Ying-Jie Peng, Dominic Dordai, Oscar Li, Daiana Drehmer, Yajing Lyu, Yongkang Yang, Walter Jackson, III, Nanduri R. Prabhakar, Alexander D. MacKerell, Jr., Gregg L. Semenza
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (5): e20251009.
https://doi.org/10.1084/jem.20251009
Published: 02 April 2026
View article titled, Targeting conserved domains of hypoxia-inducible factors for cancer therapy
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Includes: Supplementary data
Journal Articles

Targeting Mettl8-Tcf1 axis promotes CD8+ TPEX differentiation and antitumor immunity

Jiaxi Song, Dan Cui, Jiabao Wang, Xuewei Qi, Jiaxin Ma, Qing Liu, Jing Yang, Haoyu Yu, Lilin Ye, Qizhao Huang, Jia Li, Fengyin Li
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (5): e20250424.
https://doi.org/10.1084/jem.20250424
Published: 27 March 2026
View article titled, Targeting Mettl8-Tcf1 axis promotes CD8+ TPEX differentiation and antitumor immunity
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Includes: Supplementary data
Journal Articles

Local gene editing of fibroblasts in tumors reveals a new cancer-associated fibroblast state

In Special Collection:
JEM Cancer Collection 2026
Nicholas F. Kuhn, Itzia Zaleta-Linares, Kenneth H. Hu, Tristan Courau, Brittany Davidson, Tammie Tam, Chih-Wei Chu, Maxime J. Kinet, Michael D. Rosenblum, Alexis J. Combes, William A. Nyberg, Justin Eyquem, Matthew F. Krummel
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (5): e20251228.
https://doi.org/10.1084/jem.20251228
Published: 25 March 2026
View article titled, Local gene editing of fibroblasts in tumors reveals a new cancer-associated fibroblast state
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Includes: Supplementary data
Journal Articles

Myeloid diversity in tumors: Shaped by genes, location, and time

In Special Collection:
JEM Cancer Collection 2026
Maria Nogales-Pons, Mariola Munárriz-Paños, Teresa Aceña-Gonzalo, María Casanova-Acebes
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2026) 223 (4): e20252267.
https://doi.org/10.1084/jem.20252267
Published: 12 March 2026
View article titled, Myeloid diversity in tumors: Shaped by genes, location, and time
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Journal Articles

Immune checkpoint inhibitor–induced myocarditis is dependent on CD8 T cell–derived TNF and TNFR2 signaling

Kathrynne A. Warrick, Anne Katrine Z. Johansen, Mengchi Jiao, Megan E. Linnemann, Irene Saha, Suh-Chin J. Lin, Charles N. Vallez, Thomas Hagan, Jeffery D. Molkentin, Chandrashekhar Pasare
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (4): e20251717.
https://doi.org/10.1084/jem.20251717
Published: 20 February 2026
View article titled, Immune checkpoint inhibitor–induced myocarditis is dependent on CD8 T cell–derived TNF and TNFR2 signaling
Open the PDF for Immune checkpoint inhibitor–induced myocarditis is dependent on CD8 T cell–derived TNF and TNFR2 signaling in another window
Includes: Supplementary data
Journal Articles

Next-generation CRISPR screens enable causal systems immunology

In Special Collection:
JEM Immunology Collection 2026
Hao Shi, Hongbo Chi
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (3): e20241266.
https://doi.org/10.1084/jem.20241266
Published: 19 February 2026
View article titled, Next-generation CRISPR screens enable causal systems immunology
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Journal Articles

Follow the “DOTs”: Vδ1+ γδ T cells as effectors of cancer immunotherapy

Bruno Silva-Santos, Sofia Mensurado, Rafael Blanco-Domínguez, Adrian C. Hayday
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (3): e20252289.
https://doi.org/10.1084/jem.20252289
Published: 11 February 2026
View article titled, Follow the “DOTs”: Vδ1+ γδ T cells as effectors of cancer immunotherapy
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Journal Articles

Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity

Benjamin N. Ostendorf, Jonathan G. Goldstein, Shuang Liu, Foster C. Gonsalves, Jana Bilanovic, Mathias Yuan, Ji-Young Kim, Christopher Rouya, Masoud Tavazoie, Sohail F. Tavazoie
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (4): e20252290.
https://doi.org/10.1084/jem.20252290
Published: 10 February 2026
View article titled, Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity
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Includes: Supplementary data
Journal Articles

Zbtb32 promotes CD8+ T cell differentiation and function in cancer

In Special Collection:
JEM Immunology Collection 2026
Birui Pan, Qinli Sun, Ruifeng Li, Juan Feng, Jing Hao, Bowen Xie, Xiaohong Zhao, Zixuan Zhao, Peng Wei, Qiuyan Lan, Shiyuan Xie, Tian Xie, Yongzhen Chen, Kun Wei, Xuan Zhong, Hai Qi, Ling Ni, Chen Dong
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (4): e20250005.
https://doi.org/10.1084/jem.20250005
Published: 06 February 2026
View article titled, Zbtb32 promotes CD8+ T cell differentiation and function in cancer
Open the PDF for Zbtb32 promotes CD8+ T cell differentiation and function in cancer in another window
Includes: Supplementary data

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