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Journal Articles

Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection

Benjamin J. Broomfield, Chin Wee Tan, Raymond Z. Qin, Hanna Abberger, Brigette C. Duckworth, Carolina Alvarado, Lennard Dalit, Chee Leng Lee, Rekha Shandre Mugan, Zihnil A.I. Mazrad, Hiromi Muramatsu, Liana Mackiewicz, Bailey E. Williams, Jinjin Chen, Asuka Takanashi, Stewart Fabb, Marc Pellegrini, Kelly L. Rogers, Woohyun J. Moon, Colin W. Pouton, Melissa J. Davis, Stephen L. Nutt, Norbert Pardi, Verena C. Wimmer, Joanna R. Groom
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20241148.
https://doi.org/10.1084/jem.20241148
Published: 10 March 2025
View article titled, Transient inhibition of type I interferon enhances CD8<sup>+</sup> T cell stemness and vaccine protection
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Includes: Supplementary data
Journal Articles

Lymphatic transport in anti-tumor immunity and metastasis

Mengzhu Sun, Julien Angelillo, Stéphanie Hugues
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2025) 222 (3): e20231954.
https://doi.org/10.1084/jem.20231954
Published: 19 February 2025
View article titled, Lymphatic transport in anti-tumor immunity and metastasis
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Journal Articles

The MLL3/GRHL2 complex regulates malignant transformation and anti-tumor immunity in squamous cancer

Chehyun Nam, Guowei Huang, Yueyuan Zheng, Hua Zhao, Yuhao Pan, Boyan Hu, Talia Wenger, Hieu T. Van, Li-Yan Xu, En-Min Li, H. Phillip Koeffler, Kai Ge, Yali Dou, Uttam K. Sinha, Young Min Park, De-Chen Lin
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (4): e20240758.
https://doi.org/10.1084/jem.20240758
Published: 18 February 2025
View article titled, The MLL3/GRHL2 complex regulates malignant transformation and anti-tumor immunity in squamous cancer
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Includes: Supplementary data
Journal Articles

Shared pathway of WDFY4-dependent cross-presentation of immune complexes by cDC1 and cDC2

Suin Jo, Ray A. Ohara, Derek J. Theisen, Sunkyung Kim, Tiantian Liu, Christopher B. Bullock, Michelle He, Feiya Ou, Jing Chen, Sytse J. Piersma, J. Luke Postoak, Wayne M. Yokoyama, Michael S. Diamond, Theresa L. Murphy, Kenneth M. Murphy
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (4): e20240955.
https://doi.org/10.1084/jem.20240955
Published: 07 February 2025
View article titled, Shared pathway of WDFY4-dependent cross-presentation of immune complexes by cDC1 and cDC2
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Journal Articles

Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39

Sang-Nee Tan, Jing Hao, Jing Ge, Yazheng Yang, Liguo Liu, Jia Huang, Meng Lin, Xiaohong Zhao, Genyu Wang, Zhiying Yang, Ling Ni, Chen Dong
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (4): e20240445.
https://doi.org/10.1084/jem.20240445
Published: 05 February 2025
View article titled, Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39
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Includes: Supplementary data
Journal Articles

tRNA m1A modification regulates cholesterol biosynthesis to promote antitumor immunity of CD8+ T cells

In Special Collection:
Tumor Metabolism 2025
Shan Miao, Hao Li, Xiaohan Song, Yongbo Liu, Gaoyang Wang, Chen Kan, Youqiong Ye, Ru-Juan Liu, Hua-Bing Li
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (3): e20240559.
https://doi.org/10.1084/jem.20240559
Published: 28 January 2025
View article titled, tRNA m<sup>1</sup>A modification regulates cholesterol biosynthesis to promote antitumor immunity of CD8<sup>+</sup> T cells
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Includes: Supplementary data
Journal Articles

The XCL1–XCR1 axis supports intestinal tissue residency and antitumor immunity

Amir Ferry, Kianoosh M. Mempel, Alexander Monell, Miguel Reina-Campos, Nicole E. Scharping, Maximilian Heeg, Kennidy K. Takehara, Shiruyeh Schokrpur, Ning Kuo, Robert Saddawi-Konefka, J. Silvio Gutkind, Ananda W. Goldrath
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (2): e20240776.
https://doi.org/10.1084/jem.20240776
Published: 22 January 2025
View article titled, The XCL1–XCR1 axis supports intestinal tissue residency and antitumor immunity
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Journal Articles

Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis

In Special Collection:
Host-Microbe Interactions 2025 , Immunology Update Winter 2025
Joan Shang, Diane Marie Del Valle, Graham J. Britton, K.R. Mead, Urvija Rajpal, Alice Chen-Liaw, Ilaria Mogno, Zhihua Li, Rajita Menon, Edgar Gonzalez-Kozlova, Arielle Elkrief, Jonathan U. Peled, Tina Ruth Gonsalves, Neil J. Shah, Michael Postow, Jean-Frederic Colombel, Sacha Gnjatic, David M. Faleck, Jeremiah J. Faith
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20232079.
https://doi.org/10.1084/jem.20232079
Published: 12 December 2024
View article titled, Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis
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Includes: Supplementary data
Journal Articles

Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma

In Special Collection:
Tissue Microenvironment and Immune Memory
Jia Ming Nickolas Teo, Zhulin Chen, Weixin Chen, Rachael Julia Yuenyinn Tan, Qi Cao, Yingming Chu, Delin Ma, Liting Chen, Huajian Yu, Ka-Hei Lam, Terence Kin Wah Lee, Svetoslav Chakarov, Burkhard Becher, Ning Zhang, Zhao Li, Stephanie Ma, Ruidong Xue, Guang Sheng Ling
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20241442.
https://doi.org/10.1084/jem.20241442
Published: 05 December 2024
View article titled, Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma
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Includes: Supplementary data
Journal Articles

Targeting CD206+ macrophages disrupts the establishment of a key antitumor immune axis

Arja Ray, Kenneth H. Hu, Kelly Kersten, Tristan Courau, Nicholas F. Kuhn, Itzia Zaleta-Linares, Bushra Samad, Alexis J. Combes, Matthew F. Krummel
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20240957.
https://doi.org/10.1084/jem.20240957
Published: 27 November 2024
View article titled, Targeting CD206<sup>+</sup> macrophages disrupts the establishment of a key antitumor immune axis
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Journal Articles

Breathing down resistance: Tackling hypoxia to overcome immunotherapy barriers in lung cancer

Huanhuan Joyce Chen
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20241581.
https://doi.org/10.1084/jem.20241581
Published: 25 November 2024
View article titled, Breathing down resistance: Tackling hypoxia to overcome immunotherapy barriers in lung cancer
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Journal Articles

Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer

In Special Collection:
Tumor Metabolism 2025
Camila Robles-Oteíza, Katherine Hastings, Jungmin Choi, Isabelle Sirois, Arvind Ravi, Francisco Expósito, Fernando de Miguel, James R. Knight, Francesc López-Giráldez, Hyejin Choi, Nicholas D. Socci, Taha Merghoub, Mark Awad, Gad Getz, Justin Gainor, Matthew D. Hellmann, Étienne Caron, Susan M. Kaech, Katerina Politi
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20231106.
https://doi.org/10.1084/jem.20231106
Published: 25 November 2024
View article titled, Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer
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Includes: Supplementary data
Journal Articles

Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer

Brennah Murphy, Taito Miyamoto, Bryan S. Manning, Gauri Mirji, Alessio Ugolini, Toshitha Kannan, Kohei Hamada, Yanfang P. Zhu, Daniel T. Claiborne, Lu Huang, Rugang Zhang, Yulia Nefedova, Andrew Kossenkov, Filippo Veglia, Rahul Shinde, Nan Zhang
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20231967.
https://doi.org/10.1084/jem.20231967
Published: 21 November 2024
View article titled, Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer
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Includes: Supplementary data
Journal Articles

MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors

Xue Li, Han Yi, Zheyu Jin, Kaitao Jiang, Kangkang Xue, Jin Wang, Yuping Qian, Qian Xiang, Sijing Zhu, Runhe Yan, Yulong Yang, Shenfei Sun, Kai Li, Zichu Zhou, Wei Yu, Ning Jiang, Chen Ding, Xinhua Lin, Jiang Zhong, Yuchao Dong, Yanfang Liu, Xiaofei Yu
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20240959.
https://doi.org/10.1084/jem.20240959
Published: 15 November 2024
View article titled, MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors
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Includes: Supplementary data
Journal Articles

Suppression of melanoma by mice lacking MHC-II: Mechanisms and implications for cancer immunotherapy

Hexin Shi, Dawson Medler, Jianhui Wang, Rachel Browning, Aijie Liu, Sara Schneider, Claudia Duran Bojorquez, Ashwani Kumar, Xiaohong Li, Jiexia Quan, Sara Ludwig, James J. Moresco, Chao Xing, Eva Marie Y. Moresco, Bruce Beutler
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20240797.
https://doi.org/10.1084/jem.20240797
Published: 29 October 2024
View article titled, Suppression of melanoma by mice lacking MHC-II: Mechanisms and implications for cancer immunotherapy
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Includes: Supplementary data
Journal Articles

An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis

In Special Collection:
Tissue Microenvironment and Immune Memory , Tumor Metabolism 2025 , 2024: The Year in Experimental Medicine
Ian W. Folkert, William A. Molina Arocho, Tsun Ki Jerrick To, Samir Devalaraja, Irene S. Molina, Jason Shoush, Hesham Mohei, Li Zhai, Md Naushad Akhtar, Veena Kochat, Emre Arslan, Alexander J. Lazar, Khalida Wani, William P. Israel, Zhan Zhang, Venkata S. Chaluvadi, Robert J. Norgard, Ying Liu, Ashley M. Fuller, Mai T. Dang, Robert E. Roses, Giorgos C. Karakousis, John T. Miura, Douglas L. Fraker, T.S. Karin Eisinger-Mathason, M. Celeste Simon, Kristy Weber, Kai Tan, Yi Fan, Kunal Rai, Malay Haldar
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (10): e20230420.
https://doi.org/10.1084/jem.20230420
Published: 30 September 2024
View article titled, An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis
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Includes: Supplementary data
Journal Articles

Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer

In Special Collection:
Cytokines Collection 2024
Apostolia M. Tsimberidou, Farah A. Alayli, Kwame Okrah, Alexandra Drakaki, Danny N. Khalil, Shivaani Kummar, Saad A. Khan, F. Stephen Hodi, David Y. Oh, Christopher R. Cabanski, Shikha Gautam, Stefanie L. Meier, Meelad Amouzgar, Shannon M. Pfeiffer, Robin Kageyama, EnJun Yang, Marko Spasic, Michael T. Tetzlaff, Wai Chin Foo, Travis J. Hollmann, Yanyun Li, Matthew Adamow, Phillip Wong, Jonni S. Moore, Sharlene Velichko, Richard O. Chen, Dinesh Kumar, Samantha Bucktrout, Ramy Ibrahim, Ute Dugan, Lisa Salvador, Vanessa M. Hubbard-Lucey, Jill O’Donnell-Tormey, Sandra Santulli-Marotto, Lisa H. Butterfield, Diane M. Da Silva, Justin Fairchild, Theresa M. LaVallee, Lacey J. Padrón, Padmanee Sharma
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (10): e20240152.
https://doi.org/10.1084/jem.20240152
Published: 27 August 2024
View article titled, Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer
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Includes: Supplementary data
Journal Articles

Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance

In Special Collection:
Immunology Update Winter 2025
Naijun Miao, Dongqing Cao, Jingsi Jin, Guizhi Ma, Haihui Yu, Junwen Qu, Guiping Li, Caixia Gao, Dong Dong, Fan Xia, Wenwen Li
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (10): e20231486.
https://doi.org/10.1084/jem.20231486
Published: 21 August 2024
View article titled, Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8<sup>+</sup> T cell stemness maintenance
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Includes: Supplementary data
Journal Articles

The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes

In Special Collection:
Mechanisms and Models of Cancer 2024 , Tumor Metabolism 2025
Mark Esposito, John K. Amory, Yibin Kang
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (9): e20240519.
https://doi.org/10.1084/jem.20240519
Published: 12 August 2024
View article titled, The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes
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Journal Articles

Dynamic Foxp3–chromatin interaction controls tunable Treg cell function

In Special Collection:
Autoimmunity 2024
Minghong He, Xinying Zong, Beisi Xu, Wenjie Qi, Wenjun Huang, Mohamed Nadhir Djekidel, Yang Zhang, Vishwajeeth R. Pagala, Jun Li, Xiaolei Hao, Clifford Guy, Lu Bai, Richard Cross, Chunliang Li, Junmin Peng, Yongqiang Feng
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (9): e20232068.
https://doi.org/10.1084/jem.20232068
Published: 27 June 2024
View article titled, Dynamic Foxp3–chromatin interaction controls tunable Treg cell function
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Includes: Supplementary data