1-20 of 224
Tumor immunology
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Radiotherapy induces YTHDF2 in dendritic cells impairing cross-presentation and T cell function

Dapeng Chen, Liangliang Wang, Chuangyu Wen, Andras Piffko, Jason Bugno, Xianbin Yu, Pingluan Wang, Fei Ji, Emile Z. Naccasha, Jiaai Wang, Xiaona Huang, Steven J. Chmura, Sean P. Pitroda, Chuan He, Hua Laura Liang, Ralph R. Weichselbaum
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20250641.
https://doi.org/10.1084/jem.20250641
Published: 06 November 2025
View article titled, Radiotherapy induces YTHDF2 in dendritic cells impairing cross-presentation and T cell function
Open the PDF for Radiotherapy induces YTHDF2 in dendritic cells impairing cross-presentation and T cell function in another window
Includes: Supplementary data
Journal Articles

Tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity

In Special Collection:
JEM Cancer Immunotherapy 2025
Yan Xu, Zheqi Zhou, Wenzheng Chen, Fei Du, Sanling Huang, Jinhui Qi, Yuwen Zeng, Hao Su, Jiaxin Wang, Chunfu Xiao, Xiaoyu Zhao, Xiaoge Liu, Yang Feng, Chuan-Yun Li, Fan Wang, Zhaofei Liu, Yunjia Zhang, Zhi Peng, Zhaode Bu, Yang-Xin Fu, Ziyu Li, Di Wang, Chuanhui Han
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (12): e20250265.
https://doi.org/10.1084/jem.20250265
Published: 07 October 2025
View article titled, Tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity
Open the PDF for Tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity in another window
Includes: Supplementary data
Journal Articles

Specific loading of oncolytic VSV on CAR enhances CAR-T cell signaling and antitumor activity

In Special Collection:
JEM Cancer Immunotherapy 2025
Fan Xing, Xuemei Wang, Zeying Li, Liangying Zheng, Zuda Huang, Jieqing Guo, Zhihui Xi, Huolun Feng, Baijin Xia, Yingtong Lin, Fei Yu, Jie Chen, Hui Zhang
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20241851.
https://doi.org/10.1084/jem.20241851
Published: 12 September 2025
View article titled, Specific loading of oncolytic VSV on CAR enhances CAR-T cell signaling and antitumor activity
Open the PDF for Specific loading of oncolytic VSV on CAR enhances CAR-T cell signaling and antitumor activity in another window
Includes: Supplementary data
Journal Articles

Perturbation of calreticulin potentiates CD8+ T cell–mediated antitumor immunity

In Special Collection:
JEM Cancer Immunotherapy 2025
Kaiyang Tang, Lijian Wu, Yuanzhi Hu, Teng Xue, Yiteng Jin, Xindi Zhou, Ce Luo, Yaoning Zhao, Linjie Tong, Jie Dai, Di Feng, Zexian Zeng, Deng Pan
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (10): e20242360.
https://doi.org/10.1084/jem.20242360
Published: 20 August 2025
View article titled, Perturbation of calreticulin potentiates CD8+ T cell–mediated antitumor immunity
Open the PDF for Perturbation of calreticulin potentiates CD8+ T cell–mediated antitumor immunity in another window
Includes: Supplementary data
Journal Articles

Heart of the matter: Neutrophils, cancer, and cardiovascular disease

In Special Collection:
Cytokines Collection 2025
Saira Ambreen, Afshan McCarthy, Andrés Hidalgo, Jose M. Adrover
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20242402.
https://doi.org/10.1084/jem.20242402
Published: 11 August 2025
View article titled, Heart of the matter: Neutrophils, cancer, and cardiovascular disease
Open the PDF for Heart of the matter: Neutrophils, cancer, and cardiovascular disease in another window
Journal Articles

CD4+ T cell dysfunction in cancer

Hrishi Venkatesh, Lawrence Fong
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2025) 222 (9): e20241417.
https://doi.org/10.1084/jem.20241417
Published: 07 August 2025
View article titled, CD4+ T cell dysfunction in cancer
Open the PDF for CD4+ T cell dysfunction in cancer in another window
Journal Articles

Epigenetic priming as a driver of memory recall and dysfunction in T cells

Mieke Metzemaekers, Niels J. Rinzema, Ralph Stadhouders
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20241433.
https://doi.org/10.1084/jem.20241433
Published: 31 July 2025
View article titled, Epigenetic priming as a driver of memory recall and dysfunction in T cells
Open the PDF for Epigenetic priming as a driver of memory recall and dysfunction in T cells in another window
Journal Articles

PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and a cell-extrinsic fashion

In Special Collection:
JEM Cancer Immunotherapy 2025
Kristen E. Pauken, Samuel C. Markson, Thomas S. Conway, Vikram R. Juneja, Osmaan Shahid, Kelly P. Burke, Jared H. Rowe, Thao H. Nguyen, Jenna L. Collier, Jaclyn M.L. Walsh, Megan E. Fung, Jacob M. Luber, Alison E. Ringel, Jason M. Schenkel, Gordon J. Freeman, Marcia C. Haigis, Meromit Singer, Arlene H. Sharpe
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (10): e20230542.
https://doi.org/10.1084/jem.20230542
Published: 24 July 2025
View article titled, PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and a cell-extrinsic fashion
Open the PDF for PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and a cell-extrinsic fashion in another window
Includes: Supplementary data
Journal Articles

Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages

In Special Collection:
Cytokines Collection 2025 , Macrophages and Dendritic Cells in Health and Disease
Xiaoyun Li, Sofie Hedlund Møller, Jaeoh Park, Yu-Ming Chuang, Pei-Chun Hsueh, Tzu-Hsuan Chang, Kung-Chi Kao, Hector Gallart-Ayala, Yi-Hao Wang, Jhan-Jie Peng, Alessio Bevilacqua, Yi-Ru Yu, Zhiyu Li, Yann Kieffer, Domitille Peigney, Hugo Croizer, Yingxi Xu, Alfred Zippelius, Isabel C. Lopez-Mejia, Lluis Fajas, Fatima Mechta-Grigoriou, Julijana Ivanisevic, Zhengtao Xiao, Ming-Chih Ho, Ying-Chun Shen, Ping-Chih Ho
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20241426.
https://doi.org/10.1084/jem.20241426
Published: 16 July 2025
View article titled, Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages
Open the PDF for Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages in another window
Includes: Supplementary data
Journal Articles

Costimulatory connections: CARMIL2 and CD28

Lawrence P. Kane
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20250896.
https://doi.org/10.1084/jem.20250896
Published: 20 June 2025
View article titled, Costimulatory connections: CARMIL2 and CD28
Open the PDF for Costimulatory connections: CARMIL2 and CD28 in another window
Journal Articles

Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control

Kun Peng, Xiaoxue Zhao, Hongjian Li, Yang-Xin Fu, Yong Liang
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20241454.
https://doi.org/10.1084/jem.20241454
Published: 06 June 2025
View article titled, Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control
Open the PDF for Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control in another window
Journal Articles

YTHDFs as radiotherapy checkpoints in tumor immunity

In Special Collection:
JEM Cancer Immunotherapy 2025
Chuangyu Wen, Emile Z. Naccasha, Chuan He, Hua Laura Liang, Ralph R. Weichselbaum
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2025) 222 (8): e20250272.
https://doi.org/10.1084/jem.20250272
Published: 05 June 2025
View article titled, YTHDFs as radiotherapy checkpoints in tumor immunity
Open the PDF for YTHDFs as radiotherapy checkpoints in tumor immunity in another window
Journal Articles

Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation

Chae Won Kim, Hyun-Jin Kim, In Kang, Keun Bon Ku, Yumin Kim, Jang Hyun Park, Juhee Lim, Byeong Hoon Kang, Won Hyung Park, Jeongwoo La, Sungwoo Chang, Inju Hwang, Minji Kim, Stephen Ahn, Heung Kyu Lee
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20241135.
https://doi.org/10.1084/jem.20241135
Published: 22 May 2025
View article titled, Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation
Open the PDF for Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation in another window
Includes: Supplementary data
Journal Articles

A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo

Fanghui Zhang, Javier Celis-Gutierrez, Lichen Zhang, Valentin Mellado, Léna Gelard, Sophie Panigot, Daiki Mori, Liaoxun Lu, Guillaume Voisinne, Carine Vilarnau Wolek, Marielle Mello, Odile Burlet-Schiltz, Anne Gonzalez de Peredo, Frédéric Fiore, Romain Roncagalli, Yinming Liang, Marie Malissen, Bernard Malissen
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20250339.
https://doi.org/10.1084/jem.20250339
Published: 22 May 2025
View article titled, A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo
Open the PDF for A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo in another window
Includes: Supplementary data
Journal Articles

Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination

Michael T. Conlon, Jessica Y. Huang, Michael Y. Gerner
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20241311.
https://doi.org/10.1084/jem.20241311
Published: 30 April 2025
View article titled, Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination
Open the PDF for Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination in another window
Includes: Supplementary data
Journal Articles

Microbiota-centered interventions to boost immune checkpoint blockade therapies

In Special Collection:
JEM Clinical Immunology Collection 2025
Andrew A. Almonte, Simon Thomas, Laurence Zitvogel
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2025) 222 (7): e20250378.
https://doi.org/10.1084/jem.20250378
Published: 22 April 2025
View article titled, Microbiota-centered interventions to boost immune checkpoint blockade therapies
Open the PDF for Microbiota-centered interventions to boost immune checkpoint blockade therapies in another window
Journal Articles

Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment

In Special Collection:
Immunometabolism 2025
Ana Belén Plata-Gómez, Ping-Chih Ho
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2025) 222 (6): e20241102.
https://doi.org/10.1084/jem.20241102
Published: 11 April 2025
View article titled, Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment
Open the PDF for Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment in another window
Journal Articles

MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy

In Special Collection:
JEM Cancer Immunotherapy 2025
Yingying Qu, Wenhua Liang, Mingzhu Yu, Chenhui Wang, Min Luo, Lin Zhong, Zhigang Li, Feng Wang
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20241957.
https://doi.org/10.1084/jem.20241957
Published: 09 April 2025
View article titled, MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy
Open the PDF for MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy in another window
Includes: Supplementary data
Journal Articles

Tumor cell heterogeneity drives spatial organization of the intratumoral immune response

In Special Collection:
JEM Cancer Collection 2025
Miho Tanaka, Lotus Lum, Kenneth H. Hu, Piyush Chaudhary, Savannah Hughes, Cecilia Ledezma-Soto, Bushra Samad, Daphne Superville, Kenneth Ng, Arun Chumber, Ciara Benson, Zoe N. Adams, Kelly Kersten, Oscar A. Aguilar, Lawrence Fong, Alexis J. Combes, Matthew F. Krummel, Melissa Q. Reeves
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20242282.
https://doi.org/10.1084/jem.20242282
Published: 01 April 2025
View article titled, Tumor cell heterogeneity drives spatial organization of the intratumoral immune response
Open the PDF for Tumor cell heterogeneity drives spatial organization of the intratumoral immune response in another window
Journal Articles

CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy

In Special Collection:
Macrophages and Dendritic Cells in Health and Disease
Sirimuvva Tadepalli, Derek R. Clements, Hayley M. Raquer-McKay, Anja Lüdtke, Sanjana Saravanan, David Seong, Lorraine Vitek, Christopher M. Richards, Jan E. Carette, Matthias Mack, Andres Gottfried-Blackmore, Edward E. Graves, Juliana Idoyaga
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20231717.
https://doi.org/10.1084/jem.20231717
Published: 27 March 2025
View article titled, CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy
Open the PDF for CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy in another window
Includes: Supplementary data