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TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment

J Exp Med (2026) 223 (10): e20252080.

https://doi.org/10.1084/jem.20252080

Published: 07 September 2026

View article titled, TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment

Journal Articles

Tumor-reactive LAG3⁺CD8⁺ T cells diverge into terminally exhausted cells and long-lived memory T cells

In Special Collection:

JEM Cancer Immunotherapy 2026

Vaishali Aggarwal, Yangxi Sun, Chang Liu, Jian Cui, Sasikanth Manne, Yingtong Dou, Qiang Chen, Erin A. Brunazzi, Kate M. Vignali, Haiguang Wang, E. John Wherry, Creg J. Workman, Dario A.A. Vignali

J Exp Med (2026) 223 (9): e20241968.

https://doi.org/10.1084/jem.20241968

Published: 18 August 2026

View article titled, Tumor-reactive LAG3+CD8+ T cells diverge into terminally exhausted cells and long-lived memory T cells

Includes: Supplementary data

Journal Articles

CD1d remodels the tumor-infiltrating myeloid populations controlling antitumor immunity

In Special Collection:

JEM Cancer Immunotherapy 2026

Lauren Evans, Maria Conde Poole, Cenk Celik, Harshita Mishra, Michael J. Pitcher, Anita Grigoriadis, Maria Secrier, Patricia Barral

J Exp Med (2026) 223 (9): e20260216.

https://doi.org/10.1084/jem.20260216

Published: 13 August 2026

View article titled, CD1d remodels the tumor-infiltrating myeloid populations controlling antitumor immunity

Includes: Supplementary data

Journal Articles

Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models

In Special Collection:

JEM Cancer Immunotherapy 2026

J Exp Med (2026) 223 (7): e20250699.

https://doi.org/10.1084/jem.20250699

Published: 26 June 2026

View article titled, Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models

Includes: Supplementary data

Journal Articles

The transcription factor IRF8 drives tumor-specific exhaustion in CD8⁺ T cells

In Special Collection:

JEM Cancer Immunotherapy 2026

Marco Ongaro, Romane Thouenon, Isaac Crespo, Alexandre Dumez, Mélanie Charmoy, Eduardo Roman Camacho, Victoria J. Morel, Daniela Cropp, Emma Desponds, Giulio Zanette, Yi-Chuan Wang, Letizia Vergili, Laure Tillé, Inés Di Resta, Marine M. Leblond, Jésus Corria Osorio, Ping-Chih Ho, Werner Held, Grégory Verdeil

J Exp Med (2026) 223 (8): e20252115.

https://doi.org/10.1084/jem.20252115

Published: 22 June 2026

View article titled, The transcription factor IRF8 drives tumor-specific exhaustion in CD8+ T cells

Includes: Supplementary data

Journal Articles

Leveraging cDC1 biology and function for enhanced immunotherapy

In Special Collection:

JEM Cancer Immunotherapy 2026

Ross W. Ward, Uddipan Kar, Sreekumar Balan, Nina Bhardwaj

J Exp Med (2026) 223 (7): e20241199.

https://doi.org/10.1084/jem.20241199

Published: 10 June 2026

View article titled, Leveraging cDC1 biology and function for enhanced immunotherapy

Journal Articles

Cathepsin S regulates germinal center reactions and anti-tumor humoral responses

Marine Bruand, Divyanshu Srivastava, Aaron Petruzzella, Maxime Petit, Samantha Mahfoud, Natalya Katanayeva, Asli Kasapoglu, Camille Landragin, Daniele Tavernari, Eleni Balli, Giovanni Ciriello, Tatiana V. Petrova, Elisa Oricchio

J Exp Med (2026) 223 (7): e20252463.

https://doi.org/10.1084/jem.20252463

Published: 01 June 2026

View article titled, Cathepsin S regulates germinal center reactions and anti-tumor humoral responses

Includes: Supplementary data

Journal Articles

Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity

Xiaonan Ma, Henan Guo, Yuting Jia, Na Yin, Min Peng

J Exp Med (2026) 223 (7): e20252687.

https://doi.org/10.1084/jem.20252687

Published: 26 May 2026

View article titled, Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity

Includes: Supplementary data

Journal Articles

Decoding TCR specificity and T cell fate at the immunological synapse

Rundi Zhu, Yuqian Wang, Guideng Li

J Exp Med (2026) 223 (6): e20260625.

https://doi.org/10.1084/jem.20260625

Published: 21 May 2026

View article titled, Decoding TCR specificity and T cell fate at the immunological synapse

Journal Articles

CSF1R-dependent CD169-positive macrophages locally constrain melanoma growth in the skin

In Special Collection:

JEM Mucosal Immunology 2026

J Exp Med (2026) 223 (7): e20252239.

https://doi.org/10.1084/jem.20252239

Published: 21 May 2026

View article titled, CSF1R-dependent CD169-positive macrophages locally constrain melanoma growth in the skin

Journal Articles

Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2–deficient environments

In Special Collection:

JEM Cancer Collection 2026

Rafael Blanco-Domínguez, André Miguel Vaz-Pinto, Leandro Barros, Noella Lopes, Beatriz Henriques-Alves, Mariana Carreira, Carlos Labão-Almeida, Julie C. Ribot, Gonçalo J.L. Bernardes, Bruno Silva-Santos, Sofia Mensurado

J Exp Med (2026) 223 (7): e20252133.

https://doi.org/10.1084/jem.20252133

Published: 13 May 2026

View article titled, Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2–deficient environments

Journal Articles

PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity

In Special Collection:

JEM Cancer Immunotherapy 2026

Shibo Liu, Guanghao Liang, Yayun Yang, Yanyang Shi, Lihui Dong, Yue Zhao, Boyuan Mei, Jun Wang, Feng Lin, Yilin Li, Wenxin Dong, Chengyang Liu, Yuhui Cao, Dali Han, Peng R. Chen, Meng Michelle Xu

J Exp Med (2026) 223 (6): e20251779.

https://doi.org/10.1084/jem.20251779

Published: 12 May 2026

View article titled, PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity

Includes: Supplementary data

Journal Articles

When tumor contact reshapes CAR-T cells

Sangwoo Park, Marcela V. Maus

J Exp Med (2026) 223 (6): e20260645.

https://doi.org/10.1084/jem.20260645

Published: 07 May 2026

View article titled, When tumor contact reshapes CAR-T cells

Journal Articles

Rab5 improves CAR T cell efficacy via reducing fratricide and maintaining surface CAR levels

In Special Collection:

JEM Clinical Immunology Collection 2026

Meidi Gu, Kaitlin A. Read, Vipin Bhardwaj, Edmund J. Carvalho, David Nardo, Justin C. Shayne, Divanshu Shukla, Wei Liu, Donald L. Siegel, Neil C. Sheppard, Michael C. Milone, Adam D. Cohen, Alfred L. Garfall, James L. Riley

J Exp Med (2026) 223 (6): e20252564.

https://doi.org/10.1084/jem.20252564

Published: 05 May 2026

View article titled, Rab5 improves CAR T cell efficacy via reducing fratricide and maintaining surface CAR levels

Includes: Supplementary data

Journal Articles

Testing the mettle of RNA methylation in T cell exhaustion

Cansu Yerinde, Debattama Rai Sen

J Exp Med (2026) 223 (5): e20260349.

https://doi.org/10.1084/jem.20260349

Published: 27 April 2026

View article titled, Testing the mettle of RNA methylation in T cell exhaustion

Journal Articles

Targeting conserved domains of hypoxia-inducible factors for cancer therapy

Shaima Salman, Tina Y. Huang, Yousang Hwang, Anmol Kumar, Emmanuel Datan, Elizabeth E. Wicks, Ellen Cho, Sophia N. Lee, Chelsey Chen, Ying-Jie Peng, Dominic Dordai, Oscar Li, Daiana Drehmer, Yajing Lyu, Yongkang Yang, Walter Jackson, III, Nanduri R. Prabhakar, Alexander D. MacKerell, Jr., Gregg L. Semenza

J Exp Med (2026) 223 (5): e20251009.

https://doi.org/10.1084/jem.20251009

Published: 02 April 2026

View article titled, Targeting conserved domains of hypoxia-inducible factors for cancer therapy

Includes: Supplementary data

Journal Articles

Targeting Mettl8-Tcf1 axis promotes CD8⁺ T_PEX differentiation and antitumor immunity

In Special Collection:

JEM Cancer Immunotherapy 2026

Jiaxi Song, Dan Cui, Jiabao Wang, Xuewei Qi, Jiaxin Ma, Qing Liu, Jing Yang, Haoyu Yu, Lilin Ye, Qizhao Huang, Jia Li, Fengyin Li

J Exp Med (2026) 223 (5): e20250424.

https://doi.org/10.1084/jem.20250424

Published: 27 March 2026

View article titled, Targeting Mettl8-Tcf1 axis promotes CD8+ TPEX differentiation and antitumor immunity

Includes: Supplementary data

Journal Articles

Local gene editing of fibroblasts in tumors reveals a new cancer-associated fibroblast state

In Special Collection:

JEM Cancer Collection 2026

Nicholas F. Kuhn, Itzia Zaleta-Linares, Kenneth H. Hu, Tristan Courau, Brittany Davidson, Tammie Tam, Chih-Wei Chu, Maxime J. Kinet, Michael D. Rosenblum, Alexis J. Combes, William A. Nyberg, Justin Eyquem, Matthew F. Krummel

J Exp Med (2026) 223 (5): e20251228.

https://doi.org/10.1084/jem.20251228

Published: 25 March 2026

View article titled, Local gene editing of fibroblasts in tumors reveals a new cancer-associated fibroblast state

Includes: Supplementary data

Journal Articles

Myeloid diversity in tumors: Shaped by genes, location, and time

In Special Collection:

JEM Cancer Collection 2026

Maria Nogales-Pons, Mariola Munárriz-Paños, Teresa Aceña-Gonzalo, María Casanova-Acebes

J Exp Med (2026) 223 (4): e20252267.

https://doi.org/10.1084/jem.20252267

Published: 12 March 2026

View article titled, Myeloid diversity in tumors: Shaped by genes, location, and time

Journal Articles

Immune checkpoint inhibitor–induced myocarditis is dependent on CD8 T cell–derived TNF and TNFR2 signaling

Kathrynne A. Warrick, Anne Katrine Z. Johansen, Mengchi Jiao, Megan E. Linnemann, Irene Saha, Suh-Chin J. Lin, Charles N. Vallez, Thomas Hagan, Jeffery D. Molkentin, Chandrashekhar Pasare

J Exp Med (2026) 223 (4): e20251717.

https://doi.org/10.1084/jem.20251717

Published: 20 February 2026

View article titled, Immune checkpoint inhibitor–induced myocarditis is dependent on CD8 T cell–derived TNF and TNFR2 signaling

Includes: Supplementary data

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TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment

Tumor-reactive LAG3⁺CD8⁺ T cells diverge into terminally exhausted cells and long-lived memory T cells

CD1d remodels the tumor-infiltrating myeloid populations controlling antitumor immunity

Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models

The transcription factor IRF8 drives tumor-specific exhaustion in CD8⁺ T cells

Leveraging cDC1 biology and function for enhanced immunotherapy

Cathepsin S regulates germinal center reactions and anti-tumor humoral responses

Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity

Decoding TCR specificity and T cell fate at the immunological synapse

CSF1R-dependent CD169-positive macrophages locally constrain melanoma growth in the skin

Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2–deficient environments

PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity

When tumor contact reshapes CAR-T cells

Rab5 improves CAR T cell efficacy via reducing fratricide and maintaining surface CAR levels

Testing the mettle of RNA methylation in T cell exhaustion

Targeting conserved domains of hypoxia-inducible factors for cancer therapy

Targeting Mettl8-Tcf1 axis promotes CD8⁺ T_PEX differentiation and antitumor immunity

Local gene editing of fibroblasts in tumors reveals a new cancer-associated fibroblast state

Myeloid diversity in tumors: Shaped by genes, location, and time

Immune checkpoint inhibitor–induced myocarditis is dependent on CD8 T cell–derived TNF and TNFR2 signaling

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