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Journal Articles

Myeloid diversity in tumors: Shaped by genes, location, and time

Maria Nogales-Pons, Mariola Munárriz-Paños, Teresa Aceña-Gonzalo, María Casanova-Acebes

J Exp Med (2026) 223 (4): e20252267.

https://doi.org/10.1084/jem.20252267

Published: 12 March 2026

View article titled, Myeloid diversity in tumors: Shaped by genes, location, and time

Journal Articles

Immune checkpoint inhibitor–induced myocarditis is dependent on CD8 T cell–derived TNF and TNFR2 signaling

Kathrynne A. Warrick, Anne Katrine Z. Johansen, Mengchi Jiao, Megan E. Linnemann, Irene Saha, Suh-Chin J. Lin, Charles N. Vallez, Thomas Hagan, Jeffery D. Molkentin, Chandrashekhar Pasare

J Exp Med (2026) 223 (4): e20251717.

https://doi.org/10.1084/jem.20251717

Published: 20 February 2026

View article titled, Immune checkpoint inhibitor–induced myocarditis is dependent on CD8 T cell–derived TNF and TNFR2 signaling

Includes: Supplementary data

Journal Articles

Next-generation CRISPR screens enable causal systems immunology

Hao Shi, Hongbo Chi

J Exp Med (2026) 223 (3): e20241266.

https://doi.org/10.1084/jem.20241266

Published: 19 February 2026

View article titled, Next-generation CRISPR screens enable causal systems immunology

Journal Articles

Follow the “DOTs”: Vδ1⁺ γδ T cells as effectors of cancer immunotherapy

Bruno Silva-Santos, Sofia Mensurado, Rafael Blanco-Domínguez, Adrian C. Hayday

J Exp Med (2026) 223 (3): e20252289.

https://doi.org/10.1084/jem.20252289

Published: 11 February 2026

View article titled, Follow the “DOTs”: Vδ1+ γδ T cells as effectors of cancer immunotherapy

Journal Articles

Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity

Benjamin N. Ostendorf, Jonathan G. Goldstein, Shuang Liu, Foster C. Gonsalves, Jana Bilanovic, Mathias Yuan, Ji-Young Kim, Christopher Rouya, Masoud Tavazoie, Sohail F. Tavazoie

J Exp Med (2026) 223 (4): e20252290.

https://doi.org/10.1084/jem.20252290

Published: 10 February 2026

View article titled, Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity

Includes: Supplementary data

Journal Articles

Zbtb32 promotes CD8⁺ T cell differentiation and function in cancer

Birui Pan, Qinli Sun, Ruifeng Li, Juan Feng, Jing Hao, Bowen Xie, Xiaohong Zhao, Zixuan Zhao, Peng Wei, Qiuyan Lan, Shiyuan Xie, Tian Xie, Yongzhen Chen, Kun Wei, Xuan Zhong, Hai Qi, Ling Ni, Chen Dong

J Exp Med (2026) 223 (4): e20250005.

https://doi.org/10.1084/jem.20250005

Published: 06 February 2026

View article titled, Zbtb32 promotes CD8+ T cell differentiation and function in cancer

Includes: Supplementary data

Journal Articles

MHC one–two punch knocks out cancer

Amir Ghorbani, Jonathan W. Yewdell

J Exp Med (2026) 223 (2): e20252203.

https://doi.org/10.1084/jem.20252203

Published: 20 January 2026

View article titled, MHC one–two punch knocks out cancer

Journal Articles

T cell engagers emerge as a compelling therapeutic modality

In Special Collection:

Immunology Update Winter 2026

P.A. Baeuerle, K. Sauer, R. Grieshaber-Bouyer, J.S. Michaelson

J Exp Med (2025) 223 (2): e20251652.

https://doi.org/10.1084/jem.20251652

Published: 26 December 2025

View article titled, T cell engagers emerge as a compelling therapeutic modality

Journal Articles

Advances in the development of personalized neoantigen therapies

Spencer E. Mirabile-Brightman, Lisa H. Butterfield

J Exp Med (2025) 223 (2): e20241234.

https://doi.org/10.1084/jem.20241234

Published: 09 December 2025

View article titled, Advances in the development of personalized neoantigen therapies

Journal Articles

Chimeric MHC class I– and II–restricted non-self epitopes broaden antitumor T cell reactions

In Special Collection:

Immunology Update Winter 2026

Rongsheng Zhang, Rong Ma, Merrin M.L. Leong, Ian R. Watson, Kei Iida, Tomonori Yaguchi, Fumihiko Matsuda, Tasuku Honjo, Kenji Chamoto

J Exp Med (2025) 223 (2): e20250025.

https://doi.org/10.1084/jem.20250025

Published: 05 December 2025

View article titled, Chimeric MHC class I– and II–restricted non-self epitopes broaden antitumor T cell reactions

Includes: Supplementary data

Journal Articles

Radiotherapy induces YTHDF2 in dendritic cells impairing cross-presentation and T cell function

In Special Collection:

Hematopoietic Stem Cells and Myeloid Lineages in Health and Disease

Dapeng Chen, Liangliang Wang, Chuangyu Wen, Andras Piffko, Jason Bugno, Xianbin Yu, Pingluan Wang, Fei Ji, Emile Z. Naccasha, Jiaai Wang, Xiaona Huang, Steven J. Chmura, Sean P. Pitroda, Chuan He, Hua Laura Liang, Ralph R. Weichselbaum

J Exp Med (2025) 223 (1): e20250641.

https://doi.org/10.1084/jem.20250641

Published: 06 November 2025

View article titled, Radiotherapy induces YTHDF2 in dendritic cells impairing cross-presentation and T cell function

Includes: Supplementary data

Journal Articles

Tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity

In Special Collection:

JEM Cancer Immunotherapy 2025 , Innate Immune Signaling in Infection and Disease

J Exp Med (2025) 222 (12): e20250265.

https://doi.org/10.1084/jem.20250265

Published: 07 October 2025

View article titled, Tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity

Includes: Supplementary data

Journal Articles

Specific loading of oncolytic VSV on CAR enhances CAR-T cell signaling and antitumor activity

In Special Collection:

JEM Cancer Immunotherapy 2025

Fan Xing, Xuemei Wang, Zeying Li, Liangying Zheng, Zuda Huang, Jieqing Guo, Zhihui Xi, Huolun Feng, Baijin Xia, Yingtong Lin, Fei Yu, Jie Chen, Hui Zhang

J Exp Med (2025) 222 (11): e20241851.

https://doi.org/10.1084/jem.20241851

Published: 12 September 2025

View article titled, Specific loading of oncolytic VSV on CAR enhances CAR-T cell signaling and antitumor activity

Includes: Supplementary data

Journal Articles

Perturbation of calreticulin potentiates CD8⁺ T cell–mediated antitumor immunity

In Special Collection:

JEM Cancer Immunotherapy 2025

Kaiyang Tang, Lijian Wu, Yuanzhi Hu, Teng Xue, Yiteng Jin, Xindi Zhou, Ce Luo, Yaoning Zhao, Linjie Tong, Jie Dai, Di Feng, Zexian Zeng, Deng Pan

J Exp Med (2025) 222 (10): e20242360.

https://doi.org/10.1084/jem.20242360

Published: 20 August 2025

View article titled, Perturbation of calreticulin potentiates CD8+ T cell–mediated antitumor immunity

Includes: Supplementary data

Journal Articles

Heart of the matter: Neutrophils, cancer, and cardiovascular disease

In Special Collection:

Cytokines Collection 2025 , Hematopoietic Stem Cells and Myeloid Lineages in Health and Disease

Saira Ambreen, Afshan McCarthy, Andrés Hidalgo, Jose M. Adrover

J Exp Med (2025) 222 (9): e20242402.

https://doi.org/10.1084/jem.20242402

Published: 11 August 2025

View article titled, Heart of the matter: Neutrophils, cancer, and cardiovascular disease

Journal Articles

CD4⁺ T cell dysfunction in cancer

Hrishi Venkatesh, Lawrence Fong

J Exp Med (2025) 222 (9): e20241417.

https://doi.org/10.1084/jem.20241417

Published: 07 August 2025

View article titled, CD4+ T cell dysfunction in cancer

Journal Articles

Epigenetic priming as a driver of memory recall and dysfunction in T cells

Mieke Metzemaekers, Niels J. Rinzema, Ralph Stadhouders

J Exp Med (2025) 222 (9): e20241433.

https://doi.org/10.1084/jem.20241433

Published: 31 July 2025

View article titled, Epigenetic priming as a driver of memory recall and dysfunction in T cells

Journal Articles

PD-1 regulates tumor-infiltrating CD8⁺ T cells in both a cell-intrinsic and a cell-extrinsic fashion

In Special Collection:

JEM Cancer Immunotherapy 2025

Kristen E. Pauken, Samuel C. Markson, Thomas S. Conway, Vikram R. Juneja, Osmaan Shahid, Kelly P. Burke, Jared H. Rowe, Thao H. Nguyen, Jenna L. Collier, Jaclyn M.L. Walsh, Megan E. Fung, Jacob M. Luber, Alison E. Ringel, Jason M. Schenkel, Gordon J. Freeman, Marcia C. Haigis, Meromit Singer, Arlene H. Sharpe

J Exp Med (2025) 222 (10): e20230542.

https://doi.org/10.1084/jem.20230542

Published: 24 July 2025

View article titled, PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and a cell-extrinsic fashion

Includes: Supplementary data

Journal Articles

Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages

In Special Collection:

Macrophages and Dendritic Cells in Health and Disease , Cytokines Collection 2025 , 2025: The Year in Experimental Medicine

J Exp Med (2025) 222 (9): e20241426.

https://doi.org/10.1084/jem.20241426

Published: 16 July 2025

View article titled, Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages

Includes: Supplementary data

Journal Articles

Costimulatory connections: CARMIL2 and CD28

Lawrence P. Kane

J Exp Med (2025) 222 (8): e20250896.

https://doi.org/10.1084/jem.20250896

Published: 20 June 2025

View article titled, Costimulatory connections: CARMIL2 and CD28

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Myeloid diversity in tumors: Shaped by genes, location, and time

Immune checkpoint inhibitor–induced myocarditis is dependent on CD8 T cell–derived TNF and TNFR2 signaling

Next-generation CRISPR screens enable causal systems immunology

Follow the “DOTs”: Vδ1⁺ γδ T cells as effectors of cancer immunotherapy

Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity

Zbtb32 promotes CD8⁺ T cell differentiation and function in cancer

MHC one–two punch knocks out cancer

T cell engagers emerge as a compelling therapeutic modality

Advances in the development of personalized neoantigen therapies

Chimeric MHC class I– and II–restricted non-self epitopes broaden antitumor T cell reactions

Radiotherapy induces YTHDF2 in dendritic cells impairing cross-presentation and T cell function

Tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity

Specific loading of oncolytic VSV on CAR enhances CAR-T cell signaling and antitumor activity

Perturbation of calreticulin potentiates CD8⁺ T cell–mediated antitumor immunity

Heart of the matter: Neutrophils, cancer, and cardiovascular disease

CD4⁺ T cell dysfunction in cancer

Epigenetic priming as a driver of memory recall and dysfunction in T cells

PD-1 regulates tumor-infiltrating CD8⁺ T cells in both a cell-intrinsic and a cell-extrinsic fashion

Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages

Costimulatory connections: CARMIL2 and CD28

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