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The transcription factor IRF8 drives tumor-specific exhaustion in CD8⁺ T cells

Marco Ongaro, Romane Thouenon, Isaac Crespo, Alexandre Dumez, Mélanie Charmoy, Eduardo Roman Camacho, Victoria J. Morel, Daniela Cropp, Emma Desponds, Giulio Zanette, Yi-Chuan Wang, Letizia Vergili, Laure Tillé, Inés Di Resta, Marine M. Leblond, Jésus Corria Osorio, Ping-Chih Ho, Werner Held, Grégory Verdeil

J Exp Med (2026) 223 (8): e20252115.

https://doi.org/10.1084/jem.20252115

Published: 22 June 2026

View article titled, The transcription factor IRF8 drives tumor-specific exhaustion in CD8+ T cells

Includes: Supplementary data

Journal Articles

Ligand-dependent Inhibition of CD1d-restricted NKT Cell Development in Mice Transgenic for the Activating Receptor Ly49D

Roger B. Voyle, Friedrich Beermann, Rosemary K. Lees, Jens Schümann, Jacques Zimmer, Werner Held, H. Robson MacDonald

J Exp Med (2003) 197 (7): 919–925.

https://doi.org/10.1084/jem.20021615

Published: 07 April 2003

View article titled, Ligand-dependent Inhibition of CD1d-restricted NKT Cell Development in Mice Transgenic for the Activating Receptor Ly49D

Journal Articles

H-2D Ligand Expression by Ly49A ⁺ Natural Killer (NK) Cells Precludes Ligand Uptake from Environmental Cells : Implications for NK Cell Function

Jacques Zimmer, Vassilios Ioannidis, Werner Held

J Exp Med (2001) 194 (10): 1531–1539.

https://doi.org/10.1084/jem.194.10.1531

Published: 19 November 2001

View article titled, H-2D Ligand Expression by Ly49A + Natural Killer (NK) Cells Precludes Ligand Uptake from Environmental Cells : Implications for NK Cell Function

Journal Articles

T Cell Receptor Specificity Is Critical for the Development of Epidermal γδ T Cells

Isabel Ferrero, Anne Wilson, Friedrich Beermann, Werner Held, H. Robson MacDonald

J Exp Med (2001) 194 (10): 1473–1483.

https://doi.org/10.1084/jem.194.10.1473

Published: 19 November 2001

View article titled, T Cell Receptor Specificity Is Critical for the Development of Epidermal γδ T Cells

Journal Articles

Developmentally Regulated Extinction of Ly-49 Receptor Expression Permits Maturation and Selection of NK1.1⁺ T Cells

H. Robson MacDonald, Rosemary K. Lees, Werner Held

J Exp Med (1998) 187 (12): 2109–2114.

https://doi.org/10.1084/jem.187.12.2109

Published: 15 June 1998

View article titled, Developmentally Regulated Extinction of Ly-49 Receptor Expression Permits Maturation and Selection of NK1.1+ T Cells

Journal Articles

Ly49A Transgenic Mice Provide Evidence for a Major Histocompatibility Complex–dependent Education Process in Natural Killer Cell Development

Werner Held, David H. Raulet

J Exp Med (1997) 185 (12): 2079–2088.

https://doi.org/10.1084/jem.185.12.2079

Published: 16 June 1997

View article titled, Ly49A Transgenic Mice Provide Evidence for a Major Histocompatibility Complex–dependent Education Process in Natural Killer Cell Development

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The transcription factor IRF8 drives tumor-specific exhaustion in CD8⁺ T cells

Ligand-dependent Inhibition of CD1d-restricted NKT Cell Development in Mice Transgenic for the Activating Receptor Ly49D

H-2D Ligand Expression by Ly49A ⁺ Natural Killer (NK) Cells Precludes Ligand Uptake from Environmental Cells : Implications for NK Cell Function

T Cell Receptor Specificity Is Critical for the Development of Epidermal γδ T Cells

Developmentally Regulated Extinction of Ly-49 Receptor Expression Permits Maturation and Selection of NK1.1⁺ T Cells

Ly49A Transgenic Mice Provide Evidence for a Major Histocompatibility Complex–dependent Education Process in Natural Killer Cell Development

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The transcription factor IRF8 drives tumor-specific exhaustion in CD8+ T cells

Ligand-dependent Inhibition of CD1d-restricted NKT Cell Development in Mice Transgenic for the Activating Receptor Ly49D

H-2D Ligand Expression by Ly49A + Natural Killer (NK) Cells Precludes Ligand Uptake from Environmental Cells : Implications for NK Cell Function

T Cell Receptor Specificity Is Critical for the Development of Epidermal γδ T Cells

Developmentally Regulated Extinction of Ly-49 Receptor Expression Permits Maturation and Selection of NK1.1+ T Cells

Ly49A Transgenic Mice Provide Evidence for a Major Histocompatibility Complex–dependent Education Process in Natural Killer Cell Development

Email alerts

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The transcription factor IRF8 drives tumor-specific exhaustion in CD8⁺ T cells

H-2D Ligand Expression by Ly49A ⁺ Natural Killer (NK) Cells Precludes Ligand Uptake from Environmental Cells : Implications for NK Cell Function

Developmentally Regulated Extinction of Ly-49 Receptor Expression Permits Maturation and Selection of NK1.1⁺ T Cells