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  • Cover Image

    Cover Image

    issue cover

    ON THE COVER
    O’Donovan et al. show that intraneuronal activation of B-RAF kinase is sufficient to drive axon regeneration after CNS injury. The cover image represents an abstraction depicting a bundle of damaged sensory axons (colored wires), with the central burst of light symbolizing B-RAF activation and regenerative growth of axon projections. Artwork by Lewis Long (longdesign@earthlink.net).
    See page 801

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ISSN 0022-1007
EISSN 1540-9538
In this Issue

Insights

Letter

Brief Definitive Report

Type I IFN directly and selectively suppresses Cxcl2 expression by monocytes, and abrogates their ability to recruit neutrophils to the sensory ganglia following HSV-1 infection.

Modulation of central tolerance through RANKL alters thymic output and enhances anti-tumor immunity.

Granzyme B is expressed by hematopoietic stem cells (HSCs) and stromal cells in response to bacterial products or chemotherapy agents and limits HSC reconstitution potential.

Hypoxia selectively up-regulates PD-L1 on myeloid-derived suppressor cells via HIF-1a, thus affecting T cell activation.

CXCR7 antagonism augments oligodendrocyte progenitor cell proliferation to increase remyelination in vivo via CXCR4 activation.

Article

Intraneuronal activation of B-RAF kinase is sufficient to drive the growth of peripheral axon projections and enables robust regenerative axon growth in the injured optic nerve.

Neonatal mice lacking lymphatic vessels due to loss of lymphangiogenic factor CCBE1 or VEGFR3 function fail to inflate their lungs, suggestive of respiratory failure in infants with congenital pulmonary lymphangiectasia.

Zbtb20 facilitates terminal differentiation of B cells into antibody-secreting cells, and its expression is dependent on Irf4 and independent of Blimp1.

ZBTB20 promotes long-lived plasma cell survival after primary activation under alum but not TLR2- and TLR4-activating adjuvant conditions.

Liver biopsies from patients with chronic hepatitis C reveal high IFN-λR1 expression, which can be induced with IFN-α and is associated with elevated ISG expression, the IFN-λ3 minor alleles, and nonresponsiveness to peg-IFN-α and ribavirin therapy.

IKKβ functions in smooth muscle cells to regulate vascular inflammatory responses and atherosclerosis development.

MyD88-dependent GM-CSF production by endothelial cells plays a role in the initiation of obesity-associated inflammation by promoting adipose macrophage recruitment and M1-like polarization.

Strict, lineage-intrinsic requirement for continuous adult Gfi-1b expression at two distinct critical stages of erythropoiesis and megakaryopoiesis.

LRRC8A recognizes a ligand expressed on thymic epithelial cells and its expression on thymocytes is required for their development and function.

Interaction between the inhibitory molecule PD-L2 on dendritic cells and repulsive guidance molecule b (RGMb) on lung macrophages is required to establish respiratory tolerance.

Inhibition of T reg cells by type I IFNs is necessary for the generation of optimal antiviral T cell responses during acute LCMV infection.

Unlike classical class-switch recombination, class switching to IgD occurs independently of the IgH 3′ regulatory region.

Identification in humans of a bona fide marginal zone B cell population, which differentiates from a splenic marginal zone precursor through a NOTCH2 signaling pathway.

Correction

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