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Journal Articles

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

Takuma Shibata, Ryota Sato, Masato Taoka, Shin-Ichiroh Saitoh, Mayumi Komine, Kiyoshi Yamaguchi, Susumu Goyama, Yuji Motoi, Jiro Kitaura, Kumi Izawa, Yoshio Yamauchi, Yumiko Tsukamoto, Takeshi Ichinohe, Etsuko Fujita, Ryosuke Hiranuma, Ryutaro Fukui, Yoichi Furukawa, Toshio Kitamura, Toshiyuki Takai, Arinobu Tojo, Mamitaro Ohtsuki, Umeharu Ohto, Toshiyuki Shimizu, Manabu Ozawa, Nobuaki Yoshida, Toshiaki Isobe, Eicke Latz, Kojiro Mukai, Tomohiko Taguchi, Hiroaki Hemmi, Shizuo Akira, Kensuke Miyake
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (9): e20230054.
https://doi.org/10.1084/jem.20230054
Published: 18 July 2023
View article titled, TLR7/8 stress response drives histiocytosis in SLC29A3 disorders
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Journal Articles

P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

In Special Collection:
Innate Immune Cells and Signaling 2023
Lea-Marie Jenster, Karl-Elmar Lange, Sabine Normann, Anja vom Hemdt, Jennifer D. Wuerth, Lisa D.J. Schiffelers, Yonas M. Tesfamariam, Florian N. Gohr, Laura Klein, Ines H. Kaltheuner, Stefan Ebner, Dorothee J. Lapp, Jacob Mayer, Jonas Moecking, Hidde L. Ploegh, Eicke Latz, Felix Meissner, Matthias Geyer, Beate M. Kümmerer, Florian I. Schmidt
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (1): e20220837.
https://doi.org/10.1084/jem.20220837
Published: 31 October 2022
View article titled, P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection
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Includes: Supplementary data
Journal Articles

BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity

In Special Collection:
The Inflammasomes: From Mechanism to Therapeutics
Zsófia Agnes Bittner, Xiao Liu, Maria Mateo Tortola, Ana Tapia-Abellán, Sangeetha Shankar, Liudmila Andreeva, Matthew Mangan, Marianne Spalinger, Hubert Kalbacher, Peter Düwell, Marta Lovotti, Karlotta Bosch, Sabine Dickhöfer, Ana Marcu, Stefan Stevanović, Franziska Herster, Yamel Cardona Gloria, Tzu-Hsuan Chang, Francesca Bork, Carsten L. Greve, Markus W. Löffler, Olaf-Oliver Wolz, Nadine A. Schilling, Jasmin B. Kümmerle-Deschner, Samuel Wagner, Anita Delor, Bodo Grimbacher, Oliver Hantschel, Michael Scharl, Hao Wu, Eicke Latz, Alexander N.R. Weber
Journal: Journal of Experimental Medicine
J Exp Med (2021) 218 (11): e20201656.
https://doi.org/10.1084/jem.20201656
Published: 23 September 2021
View article titled, BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity
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Includes: Supplementary data
Journal Articles

TAK1ng control: TAK1 restrains NLRP3 activation

Matthew Stephen Mangan, Eicke Latz
Journal: Journal of Experimental Medicine
J Exp Med (2018) 215 (4): 1007–1008.
https://doi.org/10.1084/jem.20180282
Published: 05 March 2018
View article titled, TAK1ng control: TAK1 restrains NLRP3 activation
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Journal Articles

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

Andrea Stutz, Carl-Christian Kolbe, Rainer Stahl, Gabor L. Horvath, Bernardo S. Franklin, Olivia van Ray, Rebecca Brinkschulte, Matthias Geyer, Felix Meissner, Eicke Latz
Journal: Journal of Experimental Medicine
J Exp Med (2017) 214 (6): 1725–1736.
https://doi.org/10.1084/jem.20160933
Published: 02 May 2017
View article titled, NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain
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Includes: Supplementary data
Journal Articles

TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects

Min-Kyung Choo, Yasuyo Sano, Changhoon Kim, Kei Yasuda, Xiao-Dong Li, Xin Lin, Mary Stenzel-Poore, Lena Alexopoulou, Sankar Ghosh, Eicke Latz, Ian R. Rifkin, Zhijian J. Chen, George C. Stewart, Hyonyong Chong, Jin Mo Park
Journal: Journal of Experimental Medicine
J Exp Med (2017) 214 (5): 1297–1311.
https://doi.org/10.1084/jem.20161141
Published: 11 April 2017
View article titled, TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects
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Journal Articles

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA

Cherilyn M. Sirois, Tengchuan Jin, Allison L. Miller, Damien Bertheloot, Hirotaka Nakamura, Gabor L. Horvath, Abubakar Mian, Jiansheng Jiang, Jacob Schrum, Lukas Bossaller, Karin Pelka, Natalio Garbi, Yambasu Brewah, Jane Tian, ChewShun Chang, Partha S. Chowdhury, Gary P. Sims, Roland Kolbeck, Anthony J. Coyle, Alison A. Humbles, T. Sam Xiao, Eicke Latz
Journal: Journal of Experimental Medicine
J Exp Med (2014) 211 (5): 1001.
https://doi.org/10.1084/jem.2012020104182014c
Published: 28 April 2014
View article titled, RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA
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Journal Articles

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA

Cherilyn M. Sirois, Tengchuan Jin, Allison L. Miller, Damien Bertheloot, Hirotaka Nakamura, Gabor L. Horvath, Abubakar Mian, Jiansheng Jiang, Jacob Schrum, Lukas Bossaller, Karin Pelka, Natalio Garbi, Yambasu Brewah, Jane Tian, ChewShun Chang, Partha S. Chowdhury, Gary P. Sims, Roland Kolbeck, Anthony J. Coyle, Alison A. Humbles, T. Sam Xiao, Eicke Latz
Journal: Journal of Experimental Medicine
J Exp Med (2013) 210 (11): 2447–2463.
https://doi.org/10.1084/jem.20120201
Published: 30 September 2013
View article titled, RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA
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Includes: Supplementary data
Journal Articles

LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF

Katherine A. Fitzgerald, Daniel C. Rowe, Betsy J. Barnes, Daniel R. Caffrey, Alberto Visintin, Eicke Latz, Brian Monks, Paula M. Pitha, Douglas T. Golenbock
Journal: Journal of Experimental Medicine
J Exp Med (2003) 198 (7): 1043–1055.
https://doi.org/10.1084/jem.20031023
Published: 29 September 2003
View article titled, LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF
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Journal Articles

Molecular Genetic Analysis of an Endotoxin Nonresponder Mutant Cell Line: A Point Mutation in a Conserved Region of Md-2 Abolishes Endotoxin-Induced Signaling

Andra B. Schromm, Egil Lien, Philipp Henneke, Jesse C. Chow, Atsutoshi Yoshimura, Holger Heine, Eicke Latz, Brian G. Monks, David A. Schwartz, Kensuke Miyake, Douglas T. Golenbock
Journal: Journal of Experimental Medicine
J Exp Med (2001) 194 (1): 79–88.
https://doi.org/10.1084/jem.194.1.79
Published: 02 July 2001
View article titled, Molecular Genetic Analysis of an Endotoxin Nonresponder Mutant Cell Line: <subtitle>A Point Mutation in a Conserved Region of Md-2 Abolishes Endotoxin-Induced Signaling</subtitle>
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