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    ON THE COVER
    Shaik et al. show that that the ubiquitin E3 ligase SCFβ-TRCP promotes ubiquitination and destruction of VEGFR2 in thyroid cancer. Original image depicts immunostaining for the VEGFR2 ligand, VEGF-A (brown), which accumulates in the absence of SCFβ-TRCP. Watercolor artwork by Emilie Clark (emilie@emilieclark.com).
    See page 1289

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ISSN 0022-1007
EISSN 1540-9538
In this Issue

Minireview

Review

Brief Definitive Report

Mb1-Cre–mediated deletion of Runx1 impairs B lineage development and causes accumulation of repressive histone marks on the Ebf1 proximal promoter; ectopic expression of Ebf1 but not Pax5 restores B cell differentiation.

Article

Ileal mucus in CftrΔ508 mice is more adherent, denser, and less penetrable than that of WT mice, but addition of bicarbonate normalizes the properties of CftrΔ508 mucus.

A human antibody facilitates opsonophagocytic killing, inhibits attachment of Pseudomonas aeruginosa, and exerts protective effects in several animal models of P. aeruginosa infection.

The E3 ubiquitin ligase β-TRCP, acting in concert with casein kinase I, drives ubiquitination and degradation of VEGFR2, and renders human papillary thyroid cancer cells resistant to the VEGFR2 inhibitor sorafenib.

A genetic locus acting in hematopoietic cells regulates cytokine expression and granulocyte recruitment to confer susceptibility in a Helicobacter hepaticus–induced model of innate colitis and associated cancer.

CD47 exerts different effects on disease in distinct cell types and locations and during different stages of experimental autoimmune encephalomyelitis.

Monocytes exposed to serum from SLE patients promote B cell differentiation to IgG and IgA plasmablasts dependent on BAFF and IL-10 or APRIL, respectively.

Uropod elongation occurs during leukocyte extravasation.

VEGFR2 activates c-Src and induces vascular permeability by binding to the adaptor protein TSAd

UNG activity repairs activation-induced deaminase-generated U:G mismatches via error-prone or error-free repair, depending on the sequence context of the deaminated cytosine.

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