ON THE COVER
Articles from the teams of Matsushima and Woodland demonstrate the importance of the chemokine receptor CXCR3 in the recruitment and localization of CD8+ T cells to the splenic marginal zone of infected mice. At that site, T cells receive strong inflammatory stimulation that promotes appropriate effector versus memory responses to antigen. Image shows an abstraction of effective clustering of CXCR3+ T cells (orange) and impaired localization of CXCR3- T cells (purple). Artwork by Rachel Urkowitz (rachelurk@ earthlink.net)
See pages 1605 and 1621
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Brief Definitive Report
Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors
Both Tnfrsf1a and Tnfrsf1b are needed for the suppressive effect of TNF on murine HSC activity in vitro and in vivo.
IFN-γ– and IL-10–expressing virus epitope-specific Foxp3+ T reg cells in the central nervous system during encephalomyelitis
Pathogen-specific Foxp3+ T reg cells can be identified on the basis of cytokine production, are detected in naive T cell populations, and exhibit suppressive ability toward effector T cells with the same antigen specificity.
FoxP3-deficient mice are rescued from tissue and organ destruction and subsequent lethal autoimmune disease by the combined absence of OX40 and CD30 signals.
Loss of E2A, observed in more than 70% of patients with Sézary syndrome, which is a subtype of T cell lymphoma, results in altered expression of genes potentially relevant to oncogenesis.
Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia
Loss-of-function mutations in pten genes, or expression of a constitutively active version of Akt2, render T-ALL cell survival and disease progression independent of Myc.
Chemokine receptor CXCR3 facilitates CD8+ T cell differentiation into short-lived effector cells leading to memory degeneration
CXCR3 regulates CD8+ T cell recruitment to sites of inflammation, thus dictating CD8+ T cell contraction and subsequent effector/memory cell fate.
Inflammatory chemokine receptors regulate CD8+ T cell contraction and memory generation following infection
CD8+ T cells lacking CXCR3 and CCR5 expression have impaired contraction and generate an increased number of memory cells after virus infection.
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis
Whole-exome sequencing reveals activating STAT1 mutations in some patients with autosomal dominant chronic mucocutaneous candidiasis disease.
Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination
A complex of KAP1 and HP1 is needed to tether AID to the H3K9me3-marked donor switch region during CSR.
Human and mouse B cells lacking functional DAP12 are hyperresponsive, and DAP12 works with MAIR-II (CD300d) to negatively regulate B cell activity.
Type I interferon–responsive B cells provide early protection against bacterial sepsis.
Tissue-specific expression of B7x protects against autoimmunity.
Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain
As shown by analyses of morphology, gene expression, antigen-presenting function, and Flt3 dependence, the steady-state mouse brain contains a population of DCs that exhibits similarities to splenic DCs and differences from microglia.
Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice
Inhibition of transglutaminase 2 reduces bleomycin-induced epithelial cell release of interleukin 6 in vitro and pulmonary inflammation and fibrosis in vivo.
Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo
Cortactin is required for endothelial barrier function and leukocyte recruitment in vivo.