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Journal Articles

ICOS costimulation in combination with CTLA-4 blockade remodels tumor-associated macrophages toward an antitumor phenotype

In Special Collection:

JEM Cancer Collection 2024

Naveen Sharma, Xiaozhou Fan, Oluwatomisin T. Atolagbe, Zhongqi Ge, Kelly N. Dao, Padmanee Sharma, James P. Allison

J Exp Med (2024) 221 (4): e20231263.

https://doi.org/10.1084/jem.20231263

Published: 22 March 2024

View article titled, ICOS costimulation in combination with CTLA-4 blockade remodels tumor-associated macrophages toward an antitumor phenotype

Includes: Supplementary data

Journal Articles

Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration

In Special Collection:

Journal-Based CME Activities with Journal of Experimental Medicine (JEM) , Immunology Update Winter 2023 , JEM Cancer Collection 2023 , Microbiota, Diet, Metabolites and the Immune System 2023

J Exp Med (2022) 220 (2): e20221333.

https://doi.org/10.1084/jem.20221333

Published: 11 November 2022

View article titled, Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration

Includes: Supplementary data

Journal Articles

LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy

In Special Collection:

JEM Cancer Immunotherapy 2021

Naveen Sharma, Oluwatomisin T. Atolagbe, Zhongqi Ge, James P. Allison

J Exp Med (2021) 218 (7): e20201811.

https://doi.org/10.1084/jem.20201811

Published: 11 May 2021

View article titled, LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy

Includes: Supplementary data

Journal Articles

Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy

In Special Collection:

2018 Nobel Prize Collection

Xiaozhou Fan, Sergio A. Quezada, Manuel A. Sepulveda, Padmanee Sharma, James P. Allison

J Exp Med (2014) 211 (4): 715–725.

https://doi.org/10.1084/jem.20130590

Published: 31 March 2014

View article titled, Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy

Journal Articles

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

Tyler R. Simpson, Fubin Li, Welby Montalvo-Ortiz, Manuel A. Sepulveda, Katharina Bergerhoff, Frederick Arce, Claire Roddie, Jake Y. Henry, Hideo Yagita, Jedd D. Wolchok, Karl S. Peggs, Jeffrey V. Ravetch, James P. Allison, Sergio A. Quezada

J Exp Med (2013) 210 (9): 1695–1710.

https://doi.org/10.1084/jem.20130579

Published: 29 July 2013

View article titled, Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

Journal Articles

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4

In Special Collection:

2018 Nobel Prize Collection

Rikke B. Holmgaard, Dmitriy Zamarin, David H. Munn, Jedd D. Wolchok, James P. Allison

J Exp Med (2013) 210 (7): 1389–1402.

https://doi.org/10.1084/jem.20130066

Published: 10 June 2013

View article titled, Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4

Journal Articles

Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin

Michael A. Curran, Theresa L. Geiger, Welby Montalvo, Myoungjoo Kim, Steven L. Reiner, Aymen Al-Shamkhani, Joseph C. Sun, James P. Allison

J Exp Med (2013) 210 (4): 743–755.

https://doi.org/10.1084/jem.20121190

Published: 01 April 2013

View article titled, Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin

Journal Articles

Tissue-specific expression of B7x protects from CD4 T cell–mediated autoimmunity

Joyce Wei, P’ng Loke, Xingxing Zang, James P. Allison

J Exp Med (2011) 208 (8): 1683–1694.

https://doi.org/10.1084/jem.20100639

Published: 04 July 2011

View article titled, Tissue-specific expression of B7x protects from CD4 T cell–mediated autoimmunity

Includes: Supplementary data

Journal Articles

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

Rachel A. Gottschalk, Emily Corse, James P. Allison

J Exp Med (2010) 207 (8): 1701–1711.

https://doi.org/10.1084/jem.20091999

Published: 26 July 2010

View article titled, TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

Includes: Supplementary data

Journal Articles

Tumor-reactive CD4⁺ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

In Special Collection:

2018 Nobel Prize Collection

Sergio A. Quezada, Tyler R. Simpson, Karl S. Peggs, Taha Merghoub, Jelena Vider, Xiaozhou Fan, Ronald Blasberg, Hideo Yagita, Pawel Muranski, Paul A. Antony, Nicholas P. Restifo, James P. Allison

J Exp Med (2010) 207 (3): 637–650.

https://doi.org/10.1084/jem.20091918

Published: 15 February 2010

View article titled, Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

Includes: Supplementary data

Journal Articles

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

In Special Collection:

2018 Nobel Prize Collection

Karl S. Peggs, Sergio A. Quezada, Cynthia A. Chambers, Alan J. Korman, James P. Allison

J Exp Med (2009) 206 (8): 1717–1725.

https://doi.org/10.1084/jem.20082492

Published: 06 July 2009

View article titled, Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

Includes: Supplementary data

Journal Articles

Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma

Sergio A. Quezada, Karl S. Peggs, Tyler R. Simpson, Yuelei Shen, Dan R. Littman, James P. Allison

J Exp Med (2008) 205 (9): 2125–2138.

https://doi.org/10.1084/jem.20080099

Published: 25 August 2008

View article titled, Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma

Includes: Multimedia, Supplementary data

Journal Articles

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25⁺ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

Roger P.M. Sutmuller, Leonie M. van Duivenvoorde, Andrea van Elsas, Ton N.M. Schumacher, Manon E. Wildenberg, James P. Allison, Rene E.M. Toes, Rienk Offringa, Cornelis J.M. Melief

J Exp Med (2001) 194 (6): 823–832.

https://doi.org/10.1084/jem.194.6.823

Published: 17 September 2001

View article titled, Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

Journal Articles

Elucidating the Autoimmune and Antitumor Effector Mechanisms of a Treatment Based on Cytotoxic T Lymphocyte Antigen-4 Blockade in Combination with a B16 Melanoma Vaccine: Comparison of Prophylaxis and Therapy

In Special Collection:

2018 Nobel Prize Collection

Andrea van Elsas, Roger P.M. Sutmuller, Arthur A. Hurwitz, Jennifer Ziskin, Jennifer Villasenor, Jan-Paul Medema, Willem W. Overwijk, Nicholas P. Restifo, Cornelis J.M. Melief, Rienk Offringa, James P. Allison

J Exp Med (2001) 194 (4): 481–490.

https://doi.org/10.1084/jem.194.4.481

Published: 20 August 2001

View article titled, Elucidating the Autoimmune and Antitumor Effector Mechanisms of a Treatment Based on Cytotoxic T Lymphocyte Antigen-4 Blockade in Combination with a B16 Melanoma Vaccine: <subtitle>Comparison of Prophylaxis and Therapy</subtitle>

Journal Articles

Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

In Special Collection:

2018 Nobel Prize Collection

Andrea van Elsas, Arthur A. Hurwitz, James P. Allison

J Exp Med (1999) 190 (3): 355–366.

https://doi.org/10.1084/jem.190.3.355

Published: 02 August 1999

View article titled, Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

Journal Articles

Repression of B7.2 on Self-reactive B Cells Is Essential to Prevent Proliferation and Allow Fas-mediated Deletion by CD4⁺ T Cells

Jeffrey C. Rathmell, Sylvie Fournier, Bennett C. Weintraub, James P. Allison, Christopher C. Goodnow

J Exp Med (1998) 188 (4): 651–659.

https://doi.org/10.1084/jem.188.4.651

Published: 17 August 1998

View article titled, Repression of B7.2 on Self-reactive B Cells Is Essential to Prevent Proliferation and Allow Fas-mediated Deletion by CD4+ T Cells

Journal Articles

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes

Fred Lühder, Petter Höglund, James P. Allison, Christophe Benoist, Diane Mathis

J Exp Med (1998) 187 (3): 427–432.

https://doi.org/10.1084/jem.187.3.427

Published: 02 February 1998

View article titled, Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes

Journal Articles

Itk Negatively Regulates Induction of T Cell Proliferation by CD28 Costimulation

X. Charlene Liao, Sylvie Fournier, Nigel Killeen, Arthur Weiss, James P. Allison, Dan R. Littman

J Exp Med (1997) 186 (2): 221–228.

https://doi.org/10.1084/jem.186.2.221

Published: 21 July 1997

View article titled, Itk Negatively Regulates Induction of T Cell Proliferation by CD28 Costimulation

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ICOS costimulation in combination with CTLA-4 blockade remodels tumor-associated macrophages toward an antitumor phenotype

Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration

LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy

Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4

Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin

Tissue-specific expression of B7x protects from CD4 T cell–mediated autoimmunity

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

Tumor-reactive CD4⁺ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25⁺ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

Elucidating the Autoimmune and Antitumor Effector Mechanisms of a Treatment Based on Cytotoxic T Lymphocyte Antigen-4 Blockade in Combination with a B16 Melanoma Vaccine: Comparison of Prophylaxis and Therapy

Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

Repression of B7.2 on Self-reactive B Cells Is Essential to Prevent Proliferation and Allow Fas-mediated Deletion by CD4⁺ T Cells

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes

Itk Negatively Regulates Induction of T Cell Proliferation by CD28 Costimulation

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