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20 August 2001
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Cover Image
TGF-beta is localized within the mitochondria of normal T cells, and the absence of TGFbeta1 in TGF-beta1 null T cells results in disruption of mitochondrial membrane integrity and supersensitivity to cell death. Top left panel shows immunogold labeling for TGF-beta in normal mouse spleen T cells using goat anti-LAP (TGF-beta1) followed by a rabbit anti-goat conjugated to a 10-nm gold particle. Gold grains are localized predominantly over mitochondria. Bottom right panel shows abnormal mitochondria in TGF-beta1 null T cells. Ultrastructural examination of mitochondrial structure by transmission electron microscope reveals aberrancies including increased electron density, and dilated and lost cristae as early as gestation day 18 in fetal thymocytes. See related article in this issue by Chen et al., pp.439-453. - PDF Icon PDF LinkTable of Contents
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ISSN 0022-1007
EISSN 1540-9538
In this Issue
Article
Maturation of Dendritic Cells Is Accompanied by Rapid Transcriptional Silencing of Class II Transactivator (Ciita) Expression
Salomé Landmann,Annick Mühlethaler-Mottet,Luca Bernasconi,Tobias Suter,Jean-Marc Waldburger,Krzysztof Masternak,Jean-François Arrighi,Conrad Hauser,Adriano Fontana,Walter Reith
Identification of the Transferrin Receptor as a Novel Immunoglobulin (Ig)a1 Receptor and Its Enhanced Expression on Mesangial Cells in Iga Nephropathy
In Special Collection:
2019 Lasker Prize Collection
Ivan C. Moura,Miguel N. Centelles,Michelle Arcos-Fajardo,Denise M. Malheiros,James F. Collawn,Max D. Cooper,Renato C. Monteiro
Interference with Immunoglobulin (Ig)α Immunoreceptor Tyrosine–Based Activation Motif (Itam) Phosphorylation Modulates or Blocks B Cell Development, Depending on the Availability of an Igβ Cytoplasmic Tail
Manfred Kraus,Lily I. Pao,Amy Reichlin,Yun Hu,Beth Canono,John C. Cambier,Michel C. Nussenzweig,Klaus Rajewsky
Elucidating the Autoimmune and Antitumor Effector Mechanisms of a Treatment Based on Cytotoxic T Lymphocyte Antigen-4 Blockade in Combination with a B16 Melanoma Vaccine: Comparison of Prophylaxis and Therapy
In Special Collection:
2018 Nobel Prize Collection
Andrea van Elsas,Roger P.M. Sutmuller,Arthur A. Hurwitz,Jennifer Ziskin,Jennifer Villasenor,Jan-Paul Medema,Willem W. Overwijk,Nicholas P. Restifo,Cornelis J.M. Melief,Rienk Offringa,James P. Allison
T Cell Development and T Cell Responses in Mice with Mutations Affecting Tyrosines 292 or 315 of the Zap-70 Protein Tyrosine Kinase
Antoine Magnan,Vincenzo Di Bartolo,Anne-Marie Mura,Claude Boyer,Mireille Richelme,Yea-Lih Lin,Agnès Roure,Anne Gillet,Cécile Arrieumerlou,Oreste Acuto,Bernard Malissen,Marie Malissen
Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense
Peng Ye,Fred H. Rodriguez,Suzanne Kanaly,Kim L. Stocking,Jill Schurr,Paul Schwarzenberger,Peter Oliver,Weitao Huang,Ping Zhang,Jason Zhang,Judd E. Shellito,Greg J. Bagby,Steve Nelson,Keith Charrier,Jacques J. Peschon,Jay K. Kolls
Brief Definitive Report
Cd47 (Integrin-Associated Protein) Engagement of Dendritic Cell and Macrophage Counterreceptors Is Required to Prevent the Clearance of Donor Lymphohematopoietic Cells
Bruce R. Blazar,Frederik P. Lindberg,Elizabeth Ingulli,Angela Panoskaltsis-Mortari,Per-Arne Oldenborg,Koho Iizuka,Wayne M. Yokoyama,Patricia A. Taylor
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