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6 August 2001
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Tumor progression can be associated with Knudson-type loss of the normal alleles of certain ribosomal genes by cancer cells, making the continued expression of the mutant but antigenic ribosomal protein essential. Transfection of the genes for mutant (bottom left) or wild-type (bottom right) ribosomal protein L9 fused to the enhanced green fluorescent protein (EGFP) gene into cancer cells that have lost the normal allele leads to a cellular distribution of the fluorescent protein that is characteristic for a ribosomal protein (i.e., nucleoli are stained), while transfection of the unfused EGFP gene (top right) does not lead to specific localization. For comparison, untransfected cancer cells are shown in the top left panel. Introduction of the wild-type but not the mutant L9 fusion gene at comparable levels reverts the progressor phenotype of the cancer cells to that of a regressor phenotype in SCID mice. See related article in this issue by Beck-Engeser et al., pp. 285-299. - PDF Icon PDF LinkTable of Contents
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ISSN 0022-1007
EISSN 1540-9538
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Gntb-A, a Novel Sh2d1a-Associated Surface Molecule Contributing to the Inability of Natural Killer Cells to Kill Epstein-Barr Virus–Infected B Cells in X-Linked Lymphoproliferative Disease
Cristina Bottino,Michela Falco,Silvia Parolini,Emanuela Marcenaro,Raffaella Augugliaro,Simona Sivori,Elena Landi,Roberto Biassoni,Luigi D. Notarangelo,Lorenzo Moretta,Alessandro Moretta
Point Mutation in Essential Genes with Loss or Mutation of the Second Allele: Relevance to the Retention of Tumor-Specific Antigens
Gabriele B. Beck-Engeser,Paul A. Monach,Dominik Mumberg,Farley Yang,Sherry Wanderling,Karin Schreiber,Rafael Espinosa, III,Michelle M. Le Beau,Stephen C. Meredith,Hans Schreiber
A Critical Role for Interleukin 18 in Primary and Memory Effector Responses to Listeria monocytogenes That Extends Beyond Its Effects on Interferon γ Production
Margaret Neighbors,Xiuling Xu,Franck J. Barrat,Sigrid R. Ruuls,Tatyana Churakova,Reno Debets,J. Fernando Bazan,Robert A. Kastelein,John S. Abrams,Anne O'Garra
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