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John C. Cambier
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Journal Articles

A partial human LCK defect causes a T cell immunodeficiency with intestinal inflammation

In Special Collection:
Thymus, T Cell Development, and Inborn Errors , Immunology Update Winter 2024
Victor G. Lui, Manfred Hoenig, Berenice Cabrera-Martinez, Ryan M. Baxter, Josselyn E. Garcia-Perez, Olivia Bailey, Atanu Acharya, Karl Lundquist, Jesusa Capera, Paul Matusewicz, Frederike A. Hartl, Marco D’Abramo, Josephine Alba, Eva-Maria Jacobsen, Doris Niewolik, Myriam Lorenz, Ulrich Pannicke, Ansgar S. Schulz, Klaus-Michael Debatin, Wolfgang W. Schamel, Susana Minguet, James C. Gumbart, Michael L. Dustin, John C. Cambier, Klaus Schwarz, Elena W.Y. Hsieh
Journal: Journal of Experimental Medicine
J Exp Med (2023) 221 (1): e20230927.
https://doi.org/10.1084/jem.20230927
Published: 14 November 2023
View article titled, A partial human LCK defect causes a T cell immunodeficiency with intestinal inflammation
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Includes: Supplementary data
Journal Articles

Impaired B cell function during viral infections due to PTEN-mediated inhibition of the PI3K pathway

Andrew Getahun, Scott M. Wemlinger, Pratyaydipta Rudra, Mario L. Santiago, Linda F. van Dyk, John C. Cambier
Journal: Journal of Experimental Medicine
J Exp Med (2017) 214 (4): 931–941.
https://doi.org/10.1084/jem.20160972
Published: 24 March 2017
View article titled, Impaired B cell function during viral infections due to PTEN-mediated inhibition of the PI3K pathway
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Journal Articles

Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells

Andrew Getahun, Nicole A. Beavers, Sandy R. Larson, Mark J. Shlomchik, John C. Cambier
Journal: Journal of Experimental Medicine
J Exp Med (2016) 213 (5): 751–769.
https://doi.org/10.1084/jem.20150537
Published: 25 April 2016
View article titled, Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells
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Journal Articles

Ligand-independent Signaling Functions for the B Lymphocyte Antigen Receptor and Their Role in Positive Selection during B Lymphopoiesis

Gregory Bannish, Ezequiel M. Fuentes-Pananá, John C. Cambier, Warren S. Pear, John G. Monroe
Journal: Journal of Experimental Medicine
J Exp Med (2001) 194 (11): 1583–1596.
https://doi.org/10.1084/jem.194.11.1583
Published: 26 November 2001
View article titled, Ligand-independent Signaling Functions for the B Lymphocyte Antigen Receptor and Their Role in Positive Selection during B Lymphopoiesis
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Journal Articles

Interference with Immunoglobulin (Ig)α Immunoreceptor Tyrosine–Based Activation Motif (Itam) Phosphorylation Modulates or Blocks B Cell Development, Depending on the Availability of an Igβ Cytoplasmic Tail

Manfred Kraus, Lily I. Pao, Amy Reichlin, Yun Hu, Beth Canono, John C. Cambier, Michel C. Nussenzweig, Klaus Rajewsky
Journal: Journal of Experimental Medicine
J Exp Med (2001) 194 (4): 455–470.
https://doi.org/10.1084/jem.194.4.455
Published: 20 August 2001
View article titled, Interference with Immunoglobulin (Ig)α Immunoreceptor Tyrosine–Based Activation Motif (Itam) Phosphorylation Modulates or Blocks B Cell Development, Depending on the Availability of an Igβ Cytoplasmic Tail
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Journal Articles

Differential Regulation of B Cell Development, Activation, and Death by the Src Homology 2 Domain–Containing 5′ Inositol Phosphatase (Ship)

Anne Brauweiler, Idan Tamir, Joseph Dal Porto, Robert J. Benschop, Cheryl D. Helgason, R. Keith Humphries, John H. Freed, John C. Cambier
Journal: Journal of Experimental Medicine
J Exp Med (2000) 191 (9): 1545–1554.
https://doi.org/10.1084/jem.191.9.1545
Published: 01 May 2000
View article titled, Differential Regulation of B Cell Development, Activation, and Death by the Src Homology 2 Domain–Containing 5′ Inositol Phosphatase (Ship)
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Journal Articles

Distinct Signal Thresholds for the Unique Antigen Receptor–Linked Gene Expression Programs in Mature and Immature B Cells

Robert J. Benschop, Doron Melamed, David Nemazee, John C. Cambier
Journal: Journal of Experimental Medicine
J Exp Med (1999) 190 (6): 749–756.
https://doi.org/10.1084/jem.190.6.749
Published: 20 September 1999
View article titled, Distinct Signal Thresholds for the Unique Antigen Receptor–Linked Gene Expression Programs in Mature and Immature B Cells
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Journal Articles

Antigens Varying in Affinity for the B Cell Receptor Induce Differential B Lymphocyte Responses

Valerie Kouskoff, Sara Famiglietti, Georges Lacaud, Paul Lang, James E. Rider, Brian K. Kay, John C. Cambier, David Nemazee
Journal: Journal of Experimental Medicine
J Exp Med (1998) 188 (8): 1453–1464.
https://doi.org/10.1084/jem.188.8.1453
Published: 19 October 1998
View article titled, Antigens Varying in Affinity for the B Cell Receptor Induce Differential B Lymphocyte Responses
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Journal Articles

Qualitative Regulation of B Cell Antigen Receptor Signaling by CD19: Selective Requirement for PI3-Kinase Activation, Inositol-1,4,5-Trisphosphate Production and Ca2+ Mobilization

Anne Mette Buhl, Christopher M. Pleiman, Robert C. Rickert, John C. Cambier
Journal: Journal of Experimental Medicine
J Exp Med (1997) 186 (11): 1897–1910.
https://doi.org/10.1084/jem.186.11.1897
Published: 01 December 1997
View article titled, Qualitative Regulation of B Cell Antigen Receptor Signaling by CD19: Selective Requirement for PI3-Kinase Activation, Inositol-1,4,5-Trisphosphate Production and Ca<sup>2+</sup> Mobilization
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Journal Articles

Delivery of B Cell Receptor–internalized Antigen to Endosomes and Class II Vesicles

James R. Drake, Paul Webster, John C. Cambier, Ira Mellman
Journal: Journal of Experimental Medicine
J Exp Med (1997) 186 (8): 1299–1306.
https://doi.org/10.1084/jem.186.8.1299
Published: 20 October 1997
View article titled, Delivery of B Cell Receptor–internalized Antigen to Endosomes and Class II Vesicles
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