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Issues

ISSN 0021-9525
EISSN 1540-8140

In This Issue

In Focus

Sticky proteins help create distinctive pattern in visual center of the zebrafish brain.

People & Ideas

Pucadyil investigates membrane fission using novel model membrane systems.

Editorial

We are pleased to welcome several new JCB editorial board members.

Feature

Review

Report

Suspended cells transiently increase their volume during mitosis because of ion exchange through the plasma membrane.

Mammalian cells display a significant increase in volume during mitosis, which corresponds to a decrease in cell density, is linked to the mitotic state and not to the cell shape, and is independent of the actomyosin cortex.

Higher eukaryotes, but not yeast, are able to extract severely misfolded glycoproteins from the endoplasmic reticulum–associated degradation (ERAD) pathway for glycoproteins and target them to the ERAD pathway for non-glycoproteins to maintain the homeostasis of the ER.

Synaptonemal complex (SC) assembly requires polySUMOylation of Ecm11, which promotes polymerization of Zip1, the transverse filament, whereas the N terminus of Zip1 activates Ecm11 polySUMOylation, suggesting that this positive feedback loop underpins SC assembly.

Mice deficient for mitochondrial fission factor (Mff) die from severe cardiomyopathy, but cardiac function, tissue integrity, and mitochondrial respiration are robustly rescued by rebalancing mitochondrial dynamics through deletion of Mitofusin 1 (Mfn1).

δ-Protocadherins partition the zebrafish optic tectum into radial columns of neurons, and the neurons within a column are siblings derived from common neuronal progenitors.

Article

In vertebrate embryos, the histone demethylase KDM4B affects otic placode proliferation, intercellular adhesion, and invagination by directly regulating Dlx3 expression.

Mutations in the seipin complex components Fld1 and Ldb16 result in the loss of lipid droplet identity and phospholipid packing defects, revealing a role of this complex in the stabilization of ER–lipid droplet contact sites.

A Numb/p53 circuitry exerts a potent tumor-suppressor function in the mammary gland by safeguarding against the emergence of cancer stem cells with unchecked self-renewal and tumorigenic potential.

PAK4, via a novel kinase-independent mechanism, protects RhoU from a Rab40A/Cullin 5 ubiquitin ligase complex–driven K48 ubiquitination to regulate breast cancer cell adhesion.

Oxidative stress induces EGFR-dependent phosphorylation and activation of ZNRF1 ubiquitin ligase in neurons, which promotes two major neurodegenerative pathways, apoptosis and axonal degeneration.

A protein complementation assay quantifying TDP-43 oligomerization in living neurons shows microvesicular and bidirectional synaptic transmission of TDP-43 and TDP-43 seeding activity in human ALS postmortem brain tissue.

Tools

Protein delivery based on bacterial type III secretion allows controllable injection of bacterial, viral, and human proteins into target cells, functional interaction studies, targeting of proteins to subcellular locations, and systems-level signaling analysis of a given translocated protein.

Correction

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