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Journal Articles

Aberrant phosphorylation inactivates Numb in breast cancer causing expansion of the stem cell pool

In Special Collection:

Stem Cells and Development 2023

Maria Grazia Filippone, Stefano Freddi, Silvia Zecchini, Silvia Restelli, Ivan Nicola Colaluca, Giovanni Bertalot, Salvatore Pece, Daniela Tosoni, Pier Paolo Di Fiore

J Cell Biol (2022) 221 (12): e202112001.

https://doi.org/10.1083/jcb.202112001

Published: 06 October 2022

View article titled, Aberrant phosphorylation inactivates Numb in breast cancer causing expansion of the stem cell pool

Includes: Supplementary data

Journal Articles

miR-146 connects stem cell identity with metabolism and pharmacological resistance in breast cancer

In Special Collection:

Cancer Cell Biology 2022

Chiara Tordonato, Matteo Jacopo Marzi, Giovanni Giangreco, Stefano Freddi, Paola Bonetti, Daniela Tosoni, Pier Paolo Di Fiore, Francesco Nicassio

J Cell Biol (2021) 220 (5): e202009053.

https://doi.org/10.1083/jcb.202009053

Published: 02 April 2021

View article titled, miR-146 connects stem cell identity with metabolism and pharmacological resistance in breast cancer

Includes: Supplementary data

Journal Articles

A NUMB–EFA6B–ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility

In Special Collection:

Cell Adhesion

Martina Zobel, Andrea Disanza, Francesca Senic-Matuglia, Michel Franco, Ivan Nicola Colaluca, Stefano Confalonieri, Sara Bisi, Elisa Barbieri, Giusi Caldieri, Sara Sigismund, Salvatore Pece, Philippe Chavrier, Pier Paolo Di Fiore, Giorgio Scita

J Cell Biol (2018) 217 (9): 3161–3182.

https://doi.org/10.1083/jcb.201802023

Published: 30 July 2018

View article titled, A NUMB–EFA6B–ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility

Includes: Supplementary data

Journal Articles

A Numb–Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer

In Special Collection:

Cell Biology of Cancer 2018

Ivan Nicola Colaluca, Andrea Basile, Lee Freiburger, Veronica D'Uva, Davide Disalvatore, Manuela Vecchi, Stefano Confalonieri, Daniela Tosoni, Valentina Cecatiello, Maria Grazia Malabarba, Chun-Jiun Yang, Masatsune Kainosho, Michael Sattler, Marina Mapelli, Salvatore Pece, Pier Paolo Di Fiore

J Cell Biol (2017) 217 (2): 745–762.

https://doi.org/10.1083/jcb.201709092

Published: 21 December 2017

View article titled, A Numb–Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer

Includes: Supplementary data

Journal Articles

The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells

Daniela Tosoni, Silvia Zecchini, Marco Coazzoli, Ivan Colaluca, Giovanni Mazzarol, Alicia Rubio, Michele Caccia, Emanuele Villa, Olav Zilian, Pier Paolo Di Fiore, Salvatore Pece

J Cell Biol (2015) 211 (4): 845–862.

https://doi.org/10.1083/jcb.201505037

Published: 23 November 2015

View article titled, The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells

Includes: Supplementary data

Journal Articles

A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination

Emanuela Frittoli, Andrea Palamidessi, Paola Marighetti, Stefano Confalonieri, Fabrizio Bianchi, Chiara Malinverno, Giovanni Mazzarol, Giuseppe Viale, Ines Martin-Padura, Massimilliano Garré, Dario Parazzoli, Valentina Mattei, Salvatore Cortellino, Giovanni Bertalot, Pier Paolo Di Fiore, Giorgio Scita

J Cell Biol (2014) 206 (2): 307–328.

https://doi.org/10.1083/jcb.201403127

Published: 21 July 2014

View article titled, A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination

Includes: Supplementary data

Journal Articles

Differentiation-associated microRNAs antagonize the Rb–E2F pathway to restrict proliferation

Matteo J. Marzi, Eleonora M. R. Puggioni, Valentina Dall'Olio, Gabriele Bucci, Loris Bernard, Fabrizio Bianchi, Marco Crescenzi, Pier Paolo Di Fiore, Francesco Nicassio

J Cell Biol (2012) 199 (1): 77–95.

https://doi.org/10.1083/jcb.201206033

Published: 01 October 2012

View article titled, Differentiation-associated microRNAs antagonize the Rb–E2F pathway to restrict proliferation

Includes: Supplementary data

Journal Articles

Playing both sides: nucleophosmin between tumor suppression and oncogenesis

Pier Paolo Di Fiore

J Cell Biol (2008) 182 (1): 7–9.

https://doi.org/10.1083/jcb.200806069

Published: 14 July 2008

View article titled, Playing both sides: nucleophosmin between tumor suppression and oncogenesis

Journal Articles

It's HIP to be a hub : new trends for old-fashioned proteins

Manuela Vecchi, Pier Paolo Di Fiore

J Cell Biol (2005) 170 (2): 169–171.

https://doi.org/10.1083/jcb.200506039

Published: 11 July 2005

View article titled, It's HIP to be a hub : <subtitle>new trends for old-fashioned proteins </subtitle>

Journal Articles

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

Salvatore Pece, Michela Serresi, Elisa Santolini, Maria Capra, Esther Hulleman, Viviana Galimberti, Stefano Zurrida, Patrick Maisonneuve, Giuseppe Viale, Pier Paolo Di Fiore

J Cell Biol (2004) 167 (2): 215–221.

https://doi.org/10.1083/jcb.200406140

Published: 18 October 2004

View article titled, Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

Includes: Supplementary data

Journal Articles

Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1

Metello Innocenti, Emanuela Frittoli, Isabella Ponzanelli, John R. Falck, Saskia M. Brachmann, Pier Paolo Di Fiore, Giorgio Scita

J Cell Biol (2003) 160 (1): 17–23.

https://doi.org/10.1083/jcb.200206079

Published: 06 January 2003

View article titled, Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1

Includes: Supplementary data

Journal Articles

Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entry

Ian Marc Bonapace, Lucia Latella, Roberto Papait, Francesco Nicassio, Alessandra Sacco, Masahiro Muto, Marco Crescenzi, Pier Paolo Di Fiore

J Cell Biol (2002) 157 (6): 909–914.

https://doi.org/10.1083/jcb.200201025

Published: 10 June 2002

View article titled, Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entry

Journal Articles

Mechanisms through which Sos-1 coordinates the activation of Ras and Rac

Metello Innocenti, Pierluigi Tenca, Emanuela Frittoli, Mario Faretta, Arianna Tocchetti, Pier Paolo Di Fiore, Giorgio Scita

J Cell Biol (2002) 156 (1): 125–136.

https://doi.org/10.1083/jcb.200108035

Published: 03 January 2002

View article titled, Mechanisms through which Sos-1 coordinates the activation of Ras and Rac

Journal Articles

An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin–polymerizing machine

Giorgio Scita, Pierluigi Tenca, Liliana B. Areces, Arianna Tocchetti, Emanuela Frittoli, Giuseppina Giardina, Isabella Ponzanelli, Patrizia Sini, Metello Innocenti, Pier Paolo Di Fiore

J Cell Biol (2001) 154 (5): 1031–1044.

https://doi.org/10.1083/jcb.200103146

Published: 27 August 2001

View article titled, An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin–polymerizing machine

Includes: Supplementary data

Journal Articles

Nucleocytoplasmic Shuttling of Endocytic Proteins

Manuela Vecchi, Simona Polo, Viviane Poupon, Jan-Willem van de Loo, Alexandre Benmerah, Pier Paolo Di Fiore

J Cell Biol (2001) 153 (7): 1511–1518.

https://doi.org/10.1083/jcb.153.7.1511

Published: 25 June 2001

View article titled, Nucleocytoplasmic Shuttling of Endocytic Proteins

Journal Articles

Numb Is an Endocytic Protein

Elisa Santolini, Claudia Puri, Anna Elisabetta Salcini, Maria Cristina Gagliani, Pier Giuseppe Pelicci, Carlo Tacchetti, Pier Paolo Di Fiore

J Cell Biol (2000) 151 (6): 1345–1352.

https://doi.org/10.1083/jcb.151.6.1345

Published: 11 December 2000

View article titled, Numb Is an Endocytic Protein

Journal Articles

Tyrosine Phosphorylation of Eps15 Is Required for Ligand-Regulated, but Not Constitutive, Endocytosis

Stefano Confalonieri, Anna Elisabetta Salcini, Claudia Puri, Carlo Tacchetti, Pier Paolo Di Fiore

J Cell Biol (2000) 150 (4): 905–912.

https://doi.org/10.1083/jcb.150.4.905

Published: 21 August 2000

View article titled, Tyrosine Phosphorylation of Eps15 Is Required for Ligand-Regulated, but Not Constitutive, Endocytosis

Journal Articles

Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh₂-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn²+ Finger Protein (Plzf)

Joel Hyman, Hong Chen, Pier Paolo Di Fiore, Pietro De Camilli, Axel T. Brunger

J Cell Biol (2000) 149 (3): 537–546.

https://doi.org/10.1083/jcb.149.3.537

Published: 01 May 2000

View article titled, Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh2-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger Protein (Plzf)

Journal Articles

The Eps15 Homology (Eh) Domain-Based Interaction between Eps15 and Hrb Connects the Molecular Machinery of Endocytosis to That of Nucleocytosolic Transport

Margherita Doria, Anna Elisabetta Salcini, Emanuela Colombo, Tristram G. Parslow, Pier Giuseppe Pelicci, Pier Paolo Di Fiore

J Cell Biol (1999) 147 (7): 1379–1384.

https://doi.org/10.1083/jcb.147.7.1379

Published: 27 December 1999

View article titled, The Eps15 Homology (Eh) Domain-Based Interaction between Eps15 and Hrb Connects the Molecular Machinery of Endocytosis to That of Nucleocytosolic Transport

NARROW

Aberrant phosphorylation inactivates Numb in breast cancer causing expansion of the stem cell pool

miR-146 connects stem cell identity with metabolism and pharmacological resistance in breast cancer

A NUMB–EFA6B–ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility

A Numb–Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer

The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells

A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination

Differentiation-associated microRNAs antagonize the Rb–E2F pathway to restrict proliferation

Playing both sides: nucleophosmin between tumor suppression and oncogenesis

It's HIP to be a hub : new trends for old-fashioned proteins

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1

Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entry

Mechanisms through which Sos-1 coordinates the activation of Ras and Rac

An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin–polymerizing machine

Nucleocytoplasmic Shuttling of Endocytic Proteins

Numb Is an Endocytic Protein

Tyrosine Phosphorylation of Eps15 Is Required for Ligand-Regulated, but Not Constitutive, Endocytosis

Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh₂-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn²+ Finger Protein (Plzf)

The Eps15 Homology (Eh) Domain-Based Interaction between Eps15 and Hrb Connects the Molecular Machinery of Endocytosis to That of Nucleocytosolic Transport

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