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In Focus

The microcephaly-associated protein Asp works with calmodulin to cross-link the minus ends of spindle microtubules.

People & Ideas

Sotomayor studies how cadherin proteins mediate mechanotransduction and cell adhesion.

From the Archive

In 2005, Kedersha et al. demonstrated the dynamic interactions between cytoplasmic RNA granules.



Microtubule-dependent long-range motility of early endosomes supports directed motility of peroxisomes, lipid droplets, and endoplasmic reticulum, and this process is mediated by transient interaction between all three organelles and the endosomes.

Yeast Pex1- and Pex6-deficient cells harbor peroxisomal membrane ghosts that lack matrix proteins but contain all major peroxisomal membrane proteins and acquire matrix proteins to develop into normal peroxisomes upon Pex1 reintroduction.

Inturned-mediated complex formation of NPHP4 and DAAM1 is important for ciliogenesis and ciliary function in multiciliated cells, presumably because of its requirement for the local rearrangement of actin cytoskeleton.

Activation of retinoid X receptor γ and vitamin D receptor (VDR) heterodimer via vitamin D enhances oligodendrocyte progenitor differentiation, whereas blocking VDR impairs differentiation and myelination ex vivo.


Calmodulin is required for abnormal spindle’s (Asp’s) ability to cross-link microtubules and ensure proper centrosome inheritance in neural stem cells, but it is dispensable for Asp’s role in brain size determination.

Asp localizes to the minus ends of spindle microtubules at the pole and within the spindle and cross-links them to adjacent microtubules.

The conserved Ski2-family helicase Obelus regulates alternative splicing of the Crumbs polarity protein to control epithelial polarity and junctional organization in Drosophila.

Reversible ubiquitination strictly controls NLRC5 function: K63-linked ubiquitination of NLRC5 at lysine 1,178 mediated by TRAF2/6 generates a coherent feedforward loop to sensitize switch-like activation of NF-κB, whereas USP14 specifically removes the polyubiquitin chains from NLRC5 to enhance NLRC5-mediated inhibition.

Analysis of Pex1 and dynamin-related protein function indicates peroxisomes multiply mainly by growth and division in Saccharomyces cerevisiae, whereas no evidence was found for the previously proposed role for Pex1 in peroxisome formation by fusion of ER-derived preperoxisomal vesicles.

Epidermal keratin filaments are important components and organizers of the cornified envelope and regulate mitochondrial metabolism by modulating their membrane composition.

During neuromuscular junction maturation and repair, ephrin-A3 is expressed by all slow (Type I) fibers and only by slow fibers, and inhibits their innervation by fast motor axons via repulsive interactions with the ephrin-A3 receptor EphA8.


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