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    Tmem231 (green) localizes to the transition zone between the basal body (red) and axoneme of primary cilia (blue). The nuclei of these mouse embryonic fibroblasts are labeled magenta. Roberson et al. reveal that Tmem231, whose gene is mutated in both Meckel syndrome and orofaciodigital syndrome type 3, organizes the transition zone in order to control ciliary membrane composition.
    Image © 2015 Roberson et al.
    See page 129.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Two studies reveal that Sac2 acts as a phosphoinositide 4-phosphatase on early endosomes.

People & Ideas

Mullins has made his mark by exploring the actin cytoskeleton’s frontiers.



The cell biology of disease


A group of phosphorylatable serine residues within the nonhelical domain of NMII-B controls the ability of NMII-B to generate stable migratory front–rear polarity.


An Msh2/Msh6-dependent DNA repair mechanism mitigates the mutagenicity of photolesions and induces cell cycle responses by excising incorrect nucleotides incorporated by postreplicative translesion synthesis.

Long-term imaging via microfluidic chambers shows that two minus end–directed motors, dynein and Klp2, work in parallel at distinct subcellular structures to promote efficient nuclear congression.

Disulfide bonds involving cysteine 367 in K14 play a crucial role in the assembly, dynamics, and organization of K14-containing filaments in epidermal keratinocytes.

The TDP-43 target G3BP1 is essential for a functional interaction between stress granules and processing bodies.

The function of Sac2/INPP5F in the endocytic pathway and its activity as a 4-phosphatase suggest that Sac2/INPP5F and OCRL may cooperate in the sequential dephosphorylation of PI(4,5)P2 in a partnership that mimics that of the two phosphatase modules of synaptojanin.

Sac2 (INPP5F) is a phosphoinositide 4-phosphatase that specifically hydrolyzes PI(4)P and regulates endocytic recycling.

PINK1-phosphorylated ubiquitin chain is the genuine Parkin receptor that recruits Parkin to depolarized mitochondria.

TMEM231, a functional component of the MKS complex at the ciliary transition zone, is mutated in orofaciodigital syndrome type 3 and Meckel syndrome.

TAGLN2 stabilizes cortical F-actin and thereby maintains F-actin contents at the immunological synapse, which allows T cell activation following T cell receptor stimulation.


ADAPT is an ImageJ plug-in that can be used for rapid whole-cell analysis of time-lapse videos, thereby providing data on cell morphology, membrane velocity, and temporal changes in any fluorescent protein of interest at the cell periphery, as exemplified by the morphological characterization of cellular blebs.


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