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Cover Image
Cover Image
On the cover
Human umbilical vein endothelial cells stained for VE-cadherin (green), F-actin (red), and DNA (blue) align in the direction of fluid flow (left to right). Coon et al. demonstrate that the transmembrane domain of VE-cadherin allows endothelial cells to respond to fluid shear stress by binding to the transmembrane domains of VEGFR2 and VEGFR3, recruiting these proteins into a mechanosensory complex with the adhesion molecule PECAM-1.
Image © 2015 Coon et al.
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In This Issue
In Focus
How VE-cadherin goes with the flow
Study describes how the adhesion molecule’s transmembrane domain helps endothelial cells respond to fluid shear stress.
People & Ideas
Chiara Zurzolo: GPI knows the way to go
Zurzolo studies the trafficking of GPI-anchored proteins and how this links to human disease.
From the Archive
Damaged mitochondria get a Parkin ticket
In 2008, Narendra et al. revealed that a protein associated with Parkinson’s disease promotes the turnover of dysfunctional mitochondria.
Review
Article
A novel role of farnesylation in targeting a mitotic checkpoint protein, human Spindly, to kinetochores
The mitotic checkpoint protein Spindly is farnesylated in vivo and this modification is required for its interaction with the RZZ complex and its localization to kinetochores.
A formin-nucleated actin aster concentrates cell wall hydrolases for cell fusion in fission yeast
The formin Fus1 nucleates a novel actin structure in fission yeast, named the actin fusion focus, which consists of an aster of actin filaments whose barbed ends are focalized at a membrane proximal site and serves to focalize cell wall hydrolase delivery for cell fusion.
YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1
YB-1, which is upregulated in human sarcomas, controls the availability of the stress granule nucleator G3BP1 and thereby controls stress granule assembly.
Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia
Rab8, POSH, and TAK1 regulate synaptic growth responses, which suggests that recycling endosomes are key compartments for synaptic growth regulation in neurodegenerative processes.
miR-501-3p mediates the activity-dependent regulation of the expression of AMPA receptor subunit GluA1
Expression of the Gria1-targeting miRNA miR-501-3p is increased locally in dendrites after NMDAR activation and is required for NMDAR-dependent inhibition of GluA1 expression and long-lasting spine shrinkage and elimination.
WISp39 binds phosphorylated Coronin 1B to regulate Arp2/3 localization and Cofilin-dependent motility
WISp39 associates with Hsp90, Coronin 1B, and Slingshot phosphatase to regulate Cofilin activation and Arp2/3 complex localization at the leading edge of migrating cells.
Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex
VE-cadherin plays a critical role in endothelial shear stress mechanotransduction by interacting with VEGFRs through their transmembrane domains.
CCM2–CCM3 interaction stabilizes their protein expression and permits endothelial network formation
CCM2–CCM3 interactions protect CCM2 and CCM3 from proteasomal degradation, and both CCM2 and CCM3 are required for normal endothelial cell network formation.
L1CAM/Neuroglian controls the axon–axon interactions establishing layered and lobular mushroom body architecture
Targeted domain-specific mutations and cell type–specific rescue experiments show that L1CAM/Neuroglian is required for axon–axon interactions and yield insights into the cellular mechanisms controlling establishment of the complex mushroom body architecture.
