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In endothelial cells, the RhoGTPase Rac1 stabilizes VE-cadherin trans-dimers in mature adherens junctions by counteracting actomyosin tension.
Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins
Localization of specific chromatin domains to the nuclear lamina is mediated by YY1 and lamin A/C and is dependent on a specific histone modification profile.
Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability
Exhibiting sexually dimorphic roles in mice, BRWD1 is essential for proper meiotic chromosome condensation and telomere structure during oogenesis and for haploid-specific gene transcription during postmeiotic sperm differentiation.
As a component of the polarisome, Epo1p promotes cortical ER tethering at sites of polarized growth in budding yeast.
TRP channel–associated factors are a novel protein family that regulates TRPM8 trafficking and activity
TCAF1 and TCAF2 bind to TRPM8 and promote its cell surface trafficking but differentially regulate its gating properties, leading to opposing effects on prostate cancer cell migration.
Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission
Dynamic assembly and disassembly of F-actin on mitochondria participate in Drp1-mediated mitochondrial fission.
The ITAM protein FcRγ acts via αvβ3 integrin to counteract the high bone mass phenotype in Dap12-deficient mice.