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Cover Image
Cover Image
On the cover
During its first 60 years of publication, The Journal of Cell Biology (originally titled The Journal of Biophysical and Biochemical Cytology) has sported seven different cover designs. Shown clockwise from upper right are the covers from January 25, 1955 (the inaugural issue); January 25, 1958; January 1, 1962 (the first issue to be published as The Journal of Cell Biology); July 1, 1980; January 1, 1986; July 9, 2001; and October 11, 2004. Background image of gut epithelial cells courtesy of Marchiando et al. (2010). See page 9 for an editorial from Editor-in-Chief Alan Hall in recognition of the anniversary.
Cover design for this issue by Neil Smith (www.neilsmithillustration.co.uk). - PDF Icon PDF LinkTable of Contents
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In This Issue
In Focus
People & Ideas
Julia von Blume: Sorting through the trans-Golgi
von Blume studies the mechanisms of protein sorting in the Golgi.
From the Archive
TUNEL vision spots apoptotic cells
In 1992, Gavrieli et al. described a new assay to detect cell death in vivo.
Editorial
Review
Report
Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interaction
In endothelial cells, the RhoGTPase Rac1 stabilizes VE-cadherin trans-dimers in mature adherens junctions by counteracting actomyosin tension.
Article
Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins
Localization of specific chromatin domains to the nuclear lamina is mediated by YY1 and lamin A/C and is dependent on a specific histone modification profile.
Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability
Exhibiting sexually dimorphic roles in mice, BRWD1 is essential for proper meiotic chromosome condensation and telomere structure during oogenesis and for haploid-specific gene transcription during postmeiotic sperm differentiation.
A protein complex containing Epo1p anchors the cortical endoplasmic reticulum to the yeast bud tip
As a component of the polarisome, Epo1p promotes cortical ER tethering at sites of polarized growth in budding yeast.
TRP channel–associated factors are a novel protein family that regulates TRPM8 trafficking and activity
TCAF1 and TCAF2 bind to TRPM8 and promote its cell surface trafficking but differentially regulate its gating properties, leading to opposing effects on prostate cancer cell migration.
Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission
Dynamic assembly and disassembly of F-actin on mitochondria participate in Drp1-mediated mitochondrial fission.
Absence of Dap12 and the αvβ3 integrin causes severe osteopetrosis
The ITAM protein FcRγ acts via αvβ3 integrin to counteract the high bone mass phenotype in Dap12-deficient mice.
